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AuthorHosseini, Azar
AuthorGhorbani, Atieh
AuthorAlavi, Mohaddeseh Sadat
AuthorForouhi, Nima
AuthorRajabian, Arezoo
AuthorBoroumand-Noughabi, Samaneh
AuthorSahebkar, Amirhossein
AuthorEid, Ali H.
Available date2024-02-25T09:25:06Z
Publication Date2023-12-21
Publication NameFrontiers in Pharmacology
Identifierhttp://dx.doi.org/10.3389/fphar.2023.1305816
CitationHosseini, A., Ghorbani, A., Alavi, M. S., Forouhi, N., Rajabian, A., Boroumand-Noughabi, S., ... & Eid, A. H. (2023). Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats. Frontiers in Pharmacology, 14.
ISSN1663-9812
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85182182921&origin=inward
URIhttp://hdl.handle.net/10576/52181
AbstractIntroduction: Oxidative stress is a major instigator of various cardiovascular diseases, including myocardial infarction (MI). Despite available drugs, there is still an increased need to look for alternative therapies or identify new bioactive compounds. Sanguisorba minor (S. minor) is a native herb characterized by its potent antioxidant activity. This study was designed to evaluate the effect of S. minor against isoprenaline-induced MI. Methods: Rats were treated with the hydro-ethanolic extract of the aerial parts of S. minor at doses of 100 or 300 mg/kg orally for 9 days. Isoprenaline was injected subcutaneously at the dose of 85 mg/kg on days 8 and 9. Then, the activities of various cardiac injury markers including cardiac troponin (cTnT), lactate dehydrogenase (LDH), creatinine kinase muscle brain (CK-MB), creatinine phosphokinase (CPK), and antioxidant enzymes in serum were determined. Malondialdehyde (MDA) and thiol content were measured in cardiac tissue, and histopathological analysis was conducted. Results: Our results show that isoprenaline increased the serum levels of cTnT, LDH, CK-MB, and CPK (p < 0.001) and elevated MDA levels (p < 0.001) in cardiac tissue. Isoprenaline also reduced superoxide dismutase (SOD), catalase, and thiol content (p < 0.001). Importantly, the extract abolished isoprenaline-induced MI by elevating SOD and catalase (p < 0.001), reducing levels of MDA, and diminishing levels of cTnT, LDH, CK-MB, and CPK cardiac markers (p < 0.001). Histopathological studies of the cardiac tissue showed isoprenaline-induced injury that was significantly attenuated by the extract. Conclusion: Our results suggest that S. minor could abrogate isoprenaline-induced cardiac toxicity due to its ability to mitigate oxidative stress.
SponsorThis work was supported by the Vice Chancellor for Research and Technology of Mashhad University of Medical Sciences (Grant Number 990600). Open Access funding provided by the Qatar National Library.
Languageen
PublisherFrontiers Media SA
Subjectcardiotoxicity
herbal medicine
isoprenaline
myocardial infarction
oxidative stress
superoxide dismutase
TitleCardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats
TypeArticle
Volume Number14
ESSN1663-9812
dc.accessType Open Access


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