Laboratory Animal Research Center (Research): Recent submissions

Now showing items 81-100 of 136

    • The plasticity of pancreatic cancer stem cells: implications in therapeutic resistance 

      Patil, Kalyani; Khan, Farheen B.; Akhtar, Sabah; Ahmad, Aamir; Uddin, Shahab ( Springer Nature , 2021 , Article)
      The ever-growing perception of cancer stem cells (CSCs) as a plastic state rather than a hardwired defined entity has evolved our understanding of the functional and biological plasticity of these elusive components in ...

    • Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies 

      Nisar, Sabah; Bhat, Ajaz A.; Singh, Mayank; Karedath, Thasni; Rizwan, Arshi; ... more authors ( Frontiers Media , 2021 , Article Review)
      Circular RNAs (circRNAs) are an evolutionarily conserved novel class of non-coding endogenous RNAs (ncRNAs) found in the eukaryotic transcriptome, originally believed to be aberrant RNA splicing by-products with decreased ...

    • Cadmium: An Emerging Role in Adipose Tissue Dysfunction 

      Attia, Sarra Mohammed; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Das, Sandra Concepcion; Al-Naemi, Hamda A. ( Springer , 2021 , Article Review)
      Cadmium (Cd) is a toxic heavy metal that is widespread in the environment due to the substantial anthropogenic inputs from the agriculture and industrial sectors. The toxic impact of Cd adversely affects human health and ...

    • Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder 

      Yadav, Santosh K.; Bhat, Ajaz A.; Hashem, Sheema; Nisar, Sabah; Kamal, Madeeha; ... more authors ( Springer Nature , 2021 , Article Review)
      Attention-deficit hyperactivity disorder (ADHD) is a neurological and neurodevelopmental childhood-onset disorder characterized by a persistent pattern of inattentiveness, impulsiveness, restlessness, and hyperactivity. ...

    • Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy 

      Bhat, A.A.; Bhat, Ajaz A.; Nisar, Sabah; Maacha, Selma; Carneiro-Lobo, Tatiana Correa; ... more authors ( BMC , 2021 , Article Review)
      Esophageal cancer (EC) is a disease often marked by aggressive growth and poor prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant metastases among patients with advanced disease account ...

    • Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway 

      Kirti.S., Prabhu; Bhat, Ajaz A.; Siveen, Kodappully S.; Kuttikrishnan, Shilpa; Raza, Syed Shadab; ... more authors ( Elsevier , 2021 , Article)
      Effective treatment of lung cancer remains a significant clinical challenge due to its multidrug resistance and side effects of the current treatment options. The high mortality associated with this malignancy indicates ...

    • Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat 

      Das, Sandra Concepcion; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Al-Naemi, Hamda A. ( Frontiers Media , 2021 , Article)
      The aim of this study was to evaluate the role of chronic cadmium exposure in modulating cardiac matrix metalloproteinases (MMPs) in the heart of rats. Adult male Sprague-Dawley rats were exposed to 15 ppm CdCl2 in drinking ...

    • Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy. 

      Bhat, Ajaz A; Yousuf, Parvaiz; Wani, Nissar A; Rizwan, Arshi; Chauhan, Shyam S; ... more authors ( Springer Nature , 2021 , Article Review)
      Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have revealed the highly heterogeneous and ...

    • Role of NAD+ in regulating cellular and metabolic signaling pathways 

      Sara, Amjad; Nisar, Sabah; Bhat, Ajaz A.; Shah, Ab Rauf; Frenneaux, Michael P.; ... more authors ( Elsevier , 2021 , Article Review)
      BackgroundNicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in every living cell, is involved in a myriad of metabolic processes associated with cellular bioenergetics. For this reason, NAD+ is often ...

    • Chemokine-cytokine networks in the head and neck tumor microenvironment 

      Nisar, Sabah; Yousuf, Parvaiz; Masoodi, Tariq; Wani, Nissar A.; Hashem, Sheema; ... more authors ( MDPI , 2021 , Article Review)
      Head and neck squamous cell carcinomas (HNSCCs) are aggressive diseases with a dismal patient prognosis. Despite significant advances in treatment modalities, the five-year survival rate in patients with HNSCC has improved ...

    • miRNAs as novel immunoregulators in cancer 

      Lone, Saife N.; Bhat, Ajaz A.; Wani, Nissar A.; Karedath, Thasni; Hashem, Sheema; ... more authors ( Elsevier , 2021 , Article Review)
      The immune system is a well-known vital regulator of tumor growth, and one of the main hallmarks of cancer is evading the immune system. Immune system deregulation can lead to immune surveillance evasion, sustained cancer ...

    • Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells. 

      Chauhan, Ravi; Bhat, Ajaz A; Masoodi, Tariq; Bagga, Puneet; Reddy, Ravinder; ... more authors ( BMC , 2021 , Article Review)
      Protein ubiquitination is one of the most crucial posttranslational modifications responsible for regulating the stability and activity of proteins involved in homeostatic cellular function. Inconsistencies in the ...

    • Cardiac Myosin Binding Protein-C in Sprague Dawley (SD) Rats exposed to Sub-Chronic oral dose of Cadmium Chloride 

      Al-Borshaid, Enjoud Khalifa; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Al-Naemi, Hamda ( Qatar University Press , 2021 , Poster)
      Cadmium is one of the major environmental pollutants associated with an increment in industrial and urbanization activities. It has health consequences when it reaches the human diet through the soil, water, and plant. ...

    • The effect of acute ophiobolin A treatment on HO-mediated inflammatory processes 

      Posa, Aniko; Szabo, Renata; Szalai, Zita; Kupai, Krisztina; Deim, Zoltan; ... more authors ( SAGE Publications Ltd , 2017 , Article)
      Many microbial and plant-derived metabolites contribute to the production of inflammatory mediators and the expression of pro-inflammatory molecules. Ophiobolin A (OPA) is a fungal secondary metabolite produced by Bipolaris ...

    • Association of genes with phenotype in autism spectrum disorder. 

      Nisar, Sabah; Hashem, Sheema; Bhat, Ajaz A; Syed, Najeeb; Yadav, Santosh; ... more authors ( Impact Journals , 2019 , Article Review)
      Autism spectrum disorder (ASD) is a genetic heterogeneous neurodevelopmental disorder that is characterized by impairments in social interaction and speech development and is accompanied by stereotypical behaviors such as ...

    • Cadmium Toxicity: Oxidative Stress, Inflammation and Tissue Injury 

      Das, Sandra Concepcion; Al-Naemi, Hamda A. ( Scientific Research Publishing , 2019 , Article Review)
      Cadmium is a known environmental pollutant targeting various organs. Often implicated in cadmium toxicology is the formation of reactive oxygen species, overwhelming the free radical scavenging mechanisms and inducing ...

    • Cadmium-induced endothelial dysfunction mediated by asymmetric dimethylarginine. 

      Al-Naemi, Hamda A; Das, Sandra Concepcion ( Springer , 2020 , Article)
      Cadmium (Cd) is a naturally occurring toxic heavy metal with no known essential biological functions. Exposure to Cd increases the risk of cardiovascular disease by disrupting vascular homeostasis at the endothelium. The ...

    • 1H magnetic resonance spectroscopy of 2H-to-1H exchange quantifies the dynamics of cellular metabolism in vivo 

      Rich, Laurie J; Bagga, Puneet; Wilson, Neil E; Schnall, Mitchell D; Detre, John A; ... more authors ( Nature Research , 2020 , Article)
      Quantitative mapping of the in vivo dynamics of cellular metabolism via non-invasive imaging contributes to our understanding of the initiation and progression of diseases associated with dysregulated metabolic processes. ...

    • Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications. 

      Sher, Gulab; Salman, Nadia Aziz; Khan, Abdul Q; Prabhu, Kirti S; Raza, Afsheen; ... more authors ( Elsevier , 2020 , Article Review)
      The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor ...

    • Functional In Vivo Imaging of Tumors. 

      Haris, Mohammad; Nisar, Sabah; Hashem, Sheema; Bhat, Ajaz A; Yadav, Santosh; ... more authors ( Springer , 2020 , Book chapter)
      Noninvasive imaging of functional and molecular changes in cancer has become an indispensable tool for studying cancer in vivo. Targeting the functional and molecular changes in cancer imaging provides a platform for the ...