Vitamin D status affects proteomic profile of HDL-associated proteins and inflammatory mediators in dyslipidemia
المؤلف | Hanaa, Mousa |
المؤلف | Al saei, Aisha |
المؤلف | Razali, Rozaimi Mohamad |
المؤلف | Zughaier, Susu M. |
تاريخ الإتاحة | 2024-03-14T10:22:08Z |
تاريخ النشر | 2024-01 |
اسم المنشور | The Journal of Nutritional Biochemistry |
المعرّف | http://dx.doi.org/10.1016/j.jnutbio.2023.109472 |
الاقتباس | Mousa, H., Razali, R. M., & Zughaier, S. M. (2024). Vitamin D status affects proteomic profile of HDL-associated proteins and inflammatory mediators in dyslipidemia. The Journal of Nutritional Biochemistry, 123, 109472. |
الرقم المعياري الدولي للكتاب | 0955-2863 |
الملخص | Vitamin D deficiency and dyslipidemia have substantial implications for human health globally. Vitamin D is essential for bone metabolism and immune modulation, and its insufficiency is linked to various chronic inflammatory conditions. Dyslipidemia, characterized by low levels of high-density lipoprotein (HDL) and elevated levels of low-density lipoprotein (LDL) and triglycerides, is also prevalent. Previous research has shown a connection between vitamin D deficiency and low HDL, but the precise mechanism by which vitamin D influences HDL production and its anti-inflammatory properties remains unclear. This study aimed to investigate the proteomic profiles of individuals with and without vitamin D deficiency and dyslipidemia, specifically focusing on the effects of vitamin D on HDL production, its anti-inflammatory potential, and the molecular pathways associated with vitamin D deficiency and dyslipidemia, particularly inflammation and cancer pathways. By analyzing the proteomic profiles of 274 participants from the Qatar Biobank database, we identified 1301 proteins. Our findings indicated a decrease in HDL-associated apolipoproteins (ApoM and ApoD) in individuals with both dyslipidemia and vitamin D deficiency. Conversely, participants with these conditions exhibited increased expression of acute-phase proteins (SAA1 and SOD1), which are associated with inflammation. Pathway enrichment analysis revealed heightened inflammatory activity in individuals with vitamin D deficiency and dyslipidemia, with notable enrichments in pathways such as MAPK, JAK-STAT, Ras signaling, cytokine-cytokine receptor interaction, AGE-RAGE, ErbB signaling, and cancer pathways. Overall, cases of vitamin D deficiency showed enrichment in inflammation pathways, while individuals with both vitamin D deficiency and dyslipidemia demonstrated enhanced activation of cancer and inflammation pathways. |
راعي المشروع | This work is funded by an internal graduate student grant QUST-2-CMED-2019-6 from Qatar University . |
اللغة | en |
الناشر | Elsevier |
الموضوع | Proteomics Vitamin D HDL Apolipoproteins Inflammation Dyslipidemia |
النوع | Article |
رقم المجلد | 123 |
ESSN | 1873-4847 |
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