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AuthorMarianna, Marangi
AuthorBoughattas, Sonia
AuthorValzano, Felice
AuthorLa Bella, Gianfranco
AuthorDe Nittis, Rosella
AuthorMargaglione, Maurizio
AuthorArena, Fabio
Available date2024-03-19T07:35:59Z
Publication Date2024-02-15
Publication NameNew Microbes and New Infections
Identifierhttp://dx.doi.org/10.1016/j.nmni.2024.101228
CitationMarangi, M., Boughattas, S., Valzano, F., La Bella, G., De Nittis, R., Margaglione, M., & Arena, F. (2024). Prevalence of Blastocystis sp. and other gastrointestinal pathogens among diarrheic COVID-19 patients in Italy. New Microbes and New Infections, 101228.
ISSN2052-2975
URIhttps://www.sciencedirect.com/science/article/pii/S205229752400012X
URIhttp://hdl.handle.net/10576/53207
AbstractBackgroundGastrointestinal pathogens (GPs) contribute significantly to the burden of illness worldwide with diarrhoea being the most common among gastrointestinal symptoms (GSs). In the COVID-19 disease, diarrhoea, could be one of the initial presenting symptoms. However, no data on the potential correlation between diarrhoea-causing pathogens and SARS-CoV-2 infection are available. Therefore, we carried out a 2-years retrospective study aimed to evaluate the prevalence of “classic” GPs among SARS-CoV-2 infected and non-infected patients with diarrhoea in Italy. MethodsResults of SARS-CoV-2 research from nasopharyngeal and detection of GPs from stool swab samples by Allplex™ SARS-CoV-2 and GI Virus, Bacteria and Parasite Assay were analysed for all patients with diarrhoea referring to Policlinico Ospedaliero Universitario, Foggia, (Italy) from February 2022 to October 2023. ResultsOut of the 833 involved patients, 81 (3.9%) were COVID-19 positive, while 752 (90.3%) were COVID-19 negative. Among COVID-19-positive patients, 37% (n = 30/81) were found positive for one or more GPs with a higher prevalence of protozoan parasites (18.5%) (Blastocystis ST1-ST4 subtypes, Dientamoeba fragilis genotype I), followed by bacteria (7.4%) (Campylobacter sp., Salmonella sp.). Viral pathogens were more frequent among COVID-19 negative patients (Adenovirus, Norovirus). Among GPs, Blastocystis ST3 subtype was the most prevalent registered in the 16% of patients (p = 0.0001). ConclusionsBased on obtained results, a likely interaction between the classic GPs and SARS-CoV-2 infection can be speculated, driven by protozoan parasites. Moreover, these results also provide baseline data to understand more deeply Blastocystis sp. role in this scenario of dysbiosis, particularly in those cases of SARS-CoV-2 co-infection.
Languageen
PublisherElsevier
SubjectCOVID-19
Gastrointestinal pathogens
Diarrhoea
Hospitalized patients
Italy
TitlePrevalence of Blastocystis sp. and other gastrointestinal pathogens among diarrheic COVID-19 patients in Italy
TypeArticle
Volume Number58
Open Access user License http://creativecommons.org/licenses/by/4.0/
ESSN2052-2975
dc.accessType Abstract Only


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