Bariatric Surgery Improves Serum CD40L Levels as a Predictor of Cardiovascular Risk: Systematic Review and Meta-analysis
| Author | Jamialahamdi, Tannaz |
| Author | Eid, Ali H. |
| Author | Nguyen, Ninh T. |
| Author | Gadde, Kishore M. |
| Author | Sukhorukov, Vasily N. |
| Author | Almahmeed, Wael |
| Author | Kroh, Matthew |
| Author | Sahebkar, Amirhossein |
| Available date | 2024-05-21T07:38:57Z |
| Publication Date | 2024-04-05 |
| Publication Name | Obesity Surgery |
| Identifier | http://dx.doi.org/10.1007/s11695-024-07210-8 |
| ISSN | 0960-8923 |
| Abstract | CD40 and its ligand have been recently implicated in the pathogenesis of cardiovascular disease (CVD). This meta-analysis examined the effect of bariatric surgery in reducing circulating CD40L levels. A systematic review was performed using Embase, Google Scholar, PubMed, Scopus, and Web of Science. The meta-analysis was provided by Comprehensive Meta-Analysis (CMA) V4 software. The overall effect size was detected by a random-effects meta-analysis and the leave-one-out approach. Random-effects meta-analysis of 7 studies including 191 subjects showed a significant reduction in CD40L after bariatric surgery (standardized mean difference (SMD), − 0.531; 95% CI, − 0.981, − 0.082; p = 0.021; I2, 87.00). Circulating levels of CD40L are decreased after bariatric surgery which may represent a mechanism for improvement of metabolic profile. |
| Sponsor | This work was supported by the Russian Science Foundation (Grant # 24-45-20004). |
| Language | en |
| Subject | CD40L Immune system Inflammation Metabolic bariatric surgery Weight loss |
| Type | Article |
| Issue Number | 5 |
| Volume Number | 34 |
| ESSN | 1708-0428 |
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