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    Eco-friendly green synthesis of silver nanoparticles utilizing olive oil waste by-product and their incorporation into a chitosan-aloe vera gel composite for enhanced wound healing in acid burn injuries

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    1-s2.0-S1387700324005707-main.pdf (16.27Mb)
    Date
    2024-07-31
    Author
    Basel A., Abdel-Wahab
    Haque, Anzarul
    Faris Alotaibi, Hadil
    Alasiri, Ali S.
    AE Elnoubi, Osman
    Zaki Ahmad, Mohammad
    Pathak, Kalyani
    Albarqi, Hassan A.
    Walbi, Ismail A.
    Wahab, Shadma
    ...show more authors ...show less authors
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    Abstract
    This study focused on the green synthesis of silver nanoparticles (AgNPs) using olive oil waste by-product and their incorporation into Chitosan-Aloe-Vera gel (AgNPs/AV-CS gel). The synthesized AgNPs exhibited a hydrodynamic diameter of 43.78 ± 0.33 nm, polydispersity index (PDI) of 0.073, and a zeta potential of –32.7 ± 0.462 mV. Electron microscopy confirmed the monodispersed and spherical nature of the AgNPs, with sizes ranging from 20 to 25 nm. The green-synthesized AgNPs demonstrated potent antioxidant activity, with inhibition percentages ranging from 82.90 % to 86.73 % and IC50 values of 27.01 ± 0.398 µg/mL, 22.33 ± 0.1414 µg/mL, and 24.35 ± 0.2794 µg/mL for ABTS, DPPH, and H2O2 radicals, respectively. The AgNPs also exhibited significant antimicrobial activity, with minimum inhibitory concentrations (MIC) of 6.25 µg/mL and 9.375 µg/mL against E. coli and P. aeruginosa and MIC of 12.5 µg/mL against S. aureus and S. epidermidis. Moreover, the AgNPs/AV-CS gel formulation demonstrated remarkable wound healing capabilities, achieving a 74.86 % wound contraction by day 7 and complete wound closure by day 21. Histopathological analysis revealed reduced inflammation, extensive fibrosis, and a well-developed dermis with the application of AgNPs/AV-CS gel. Overall, the results suggest that AgNPs/AV-CS gel holds promise as a therapeutic option for acid burn injuries, promoting enhanced wound healing.
    URI
    https://www.sciencedirect.com/science/article/pii/S1387700324005707
    DOI/handle
    http://dx.doi.org/10.1016/j.inoche.2024.112587
    http://hdl.handle.net/10576/55689
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    • Central Laboratories Unit Research [‎114‎ items ]

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