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AuthorAyat G., Lashen
AuthorAlmalki, Nabeelah
AuthorToss, Michael
AuthorMirza, Sameer
AuthorMalki, Mohammed Imad
AuthorRutland, Catrin S.
AuthorJeyapalan, Jennie N.
AuthorGreen, Andrew R.
AuthorMongan, Nigel P.
AuthorMadhusudan, Srinivasan
AuthorRakha, Emad A.
Available date2024-07-09T05:12:09Z
Publication Date2024-06-08
Publication NamePathology
Identifierhttp://dx.doi.org/10.1016/j.pathol.2024.03.012
CitationLashen AG et al., The characteristics and prognostic significance of histone H1 expression in breast cancer, Pathology, https:// doi.org/10.1016/j.pathol.2024.03.012
ISSN00313025
URIhttps://www.sciencedirect.com/science/article/pii/S0031302524001430
URIhttp://hdl.handle.net/10576/56518
AbstractHistone H1 (H.H1) is involved in chromatin organisation and gene regulation and is overexpressed in many malignant tumours, including breast cancer (BC). This study proposed and evaluated the prognostic role of H.H1 expression in BC.H.H1 mRNA expression was evaluated in publicly available BC dataset bc-GenExMiner database (n=4421). H.H1 protein expression was assessed immunohistochemically in a well-characterised early-stage BC cohort (n=1311), and associations with clinicopathological data and survival outcomes were evaluated.At the mRNA level, there was a significant association between high H.H1 mRNA and basal-like BC subtype and with poor outcome. The association with shorter survival was observed in the whole cohort and in the basal-like class. H.H1 protein expression was detected in both tumour cells and surrounding stroma. Total expression was detected in 72% of the cases, including 28% in tumour cell nuclei and 44% in the stroma. There was strong association between high tumour H.H1 expression and triple-negative BC (TNBC) subtype (p=0.007) and with shorter survival (p=0.019), independent of other variables including tumour size, histologic tumour grade, and lymph node status.H.H1 expression is associated with poor prognosis in BC. Given poor prognostic role of H.H1 in TNBC, it may represent a potential therapeutic target for patients with this aggressive disease.
SponsorThis study was approved by the Yorkshire and the Humber-Leeds East Research Ethics Committee (REC Reference: 19/YH/0293) under the IRAS Project ID: 266925. The collected data were used fully anonymised.
Languageen
PublisherElsevier
SubjectBreast cancer
histone H1
endocrine
prognosis
molecular classes
TitleThe characteristics and prognostic significance of histone H1 expression in breast cancer
TypeArticle
ESSN1465-3931
dc.accessType Full Text


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