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AuthorNaushad, Vamanjore A
AuthorPurayil, Nishan K
AuthorChandra, Prem
AuthorSaeed, Abazar Ahmad M
AuthorRadhakrishnan, Pradeep
AuthorVarikkodan, Irfan
AuthorMathew, Joe V
AuthorSirajudeen, Jaseem
AuthorHammamy, Riyadh A
AuthorBadi, Ahmad M
AuthorSuliman, Aasir M
AuthorBadawi, Mohamed N
AuthorArya, Saket
AuthorAlMotawa, Maryam
AuthorAl-Baker, Aisha
AuthorAlatom, Rania
AuthorKartha, Anand
Available date2024-07-22T09:19:57Z
Publication Date2022
Publication NameBMJ Open
ResourceScopus
Identifierhttp://dx.doi.org/10.1136/bmjopen-2022-061610
ISSN20446055
URIhttp://hdl.handle.net/10576/56900
AbstractObjective To compare the patient profile and outcomes in Qatar during the first and second waves of the COVID-19 pandemic. Setting A retrospective observational study was conducted comparing the demographic, clinical and laboratory characteristics of patients with COVID-19 infection admitted to a secondary care hospital, during the first and second waves of the pandemic. Participants 1039 patients from the first wave and 991 from the second wave who had pneumonia on chest X-ray and had a confirmed SARS-CoV-2 infection by a real-time PCR test of a nasopharyngeal swab were included. Patients with a normal chest X-ray and those who had a negative PCR test despite a positive COVID-19 antigen test were excluded. Outcome Length of stay, need for mechanical ventilation, final disposition and mortality were the key outcomes studied Results Influenza like symptoms (18.5% in the first wave vs 36.1% in the second wave, p 0.001), cough (79.2% vs 87%, p<0.001) and dyspnoea (27.5% vs 38% p<0.001) were more common in the second wave. Second wave patients had significantly higher respiratory rate, lower peripheral oxygen saturation, needed more supplemental oxygen and had higher incidence of pulmonary embolism. More patients received hydroxychloroquine and antibiotics during the first wave and more received steroids, antivirals and interleukin-1 antagonist during the second wave. The second wave had a shorter length of stay (14.58±7.75 vs 12.61±6.16, p<0.001) and more patients were discharged home (22% vs 10%, p<0.001). Conclusions Patients who presented during the second wave of COVID-19 pandemic appeared to be more ill clinically and based on their laboratory parameters. They required shorter hospitalisation and were more likely to be discharged home. This could represent greater expertise in handling such patients that was acquired during the first wave as well as use of more appropriate and combination therapies during the second wave.
Languageen
PublisherBMJ Publishing Group
SubjectCOVID-19
epidemiology
infectious diseases
TitleComparison of demographic, clinical and laboratory characteristics between first and second COVID-19 waves in a secondary care hospital in Qatar: a retrospective study
TypeArticle
Issue Number6
Volume Number12
dc.accessType Open Access


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