Browsing College of Pharmacy by Publication Date
Now showing items 1-20 of 58
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SUCCINYLATED CURCUMIN LOADED IN MANNOSYLATED CHITOSAN NANOPARTICLES FOR COLON CANCER THERAPY
(06-2 , Master Thesis)Colon cancer (CRC) is the second leading cause of death and the third most diagnosed type worldwide. Although curcumin (CUR) has potent anticancer activity, it suffers from low solubility, bioavailability, and instability. ... -
THE EFFECT OF NATURAL AND SYNTHETIC COMPOUNDS ON COLORECTAL CANCER: IN VITRO AND IN VIVO STUDIES
(06-2 , Master Thesis)Colorectal cancer (CRC) is one of the deadliest malignancies in the world. Despite improved treatment, CRC incidence and mortality rates have been increasing lately. Current conventional therapies are associated with severe ... -
ANTICANCER EFFECTS OF MODIFIED CITRUS PECTIN AND CURCUMIN IN CHITOSAN NANOPARTICLES ON COLON CANCER
(06-2 , Master Thesis)We aimed to study the influence of stirring effect while modifying citrus pectin (CP), in addition to create a combination of curcumin in chitosan-modified citrus pectin (CCM-NPs) nanoparticles, along with Galectin-3 in ... -
The Cellular Interplay Between Na+/H+ Exchanger Isoform I and Osteopontin in Cardiac Hypertrophy
(2014 , Master Thesis)The Na+/H+ exchanger-1 (NHE1) is a ubiquitously expressed housekeeping glycoprotein that functions to regulate intracellular pH. Enhanced expression/activity of NHE1 has been implicated in cardiac hypertrophy (CH). Recently, ... -
STANDARDIZATION OF AN IN VITRO MODEL OF DIABETIC NEPHROPATHY IN RENAL TUBULAR CELLS AND INVESTIGATION OF THE ROLE OF ALDOSE REDUCTASE PATHWAY IN HIGH GLUCOSE-INDUCED RENAL CELL INJURY
(2015 , Master Thesis)Diabetic nephropathy (DN) is the leading cause of end stage renal disease, and one of the most serious microvascular complications of diabetes mellitus. Increase in the shift of glucose into the aldose reductase pathway ... -
Synthesis and Pharmacological Evaluation of Different Piperine Analogs for Therapeutic Potential to Prevent ER Stress
(2015 , Master Thesis)Background: Endoplasmic reticulum (ER) is the chief organelle involved in protein folding and maturation. Emerging studies implicate the role of ER stress in the development of chronic kidney disease (CKD). Thus, there is ... -
SYNTHESIS, CHARACTERIZATION AND CYTOCOMPATIBILITY OF HIGHLY POROUS, THREE DIMENSIONAL POLY (1, 10 DECANEDIOL CO-TRICARBALLYLATE) BASED SCAFFOLDS FOR CARDIAC & OTHER TISSUE ENGINEERING APPLICATIONS
(2016 , Master Thesis)Electrospinning is one of the recently developed methods that produces scaffolds resembling the natural extracellular matrix. It can utilize a wide array of natural and synthetic polymer materials to produce three dimensional, ... -
EVALUATION OF A CUMULATIVE EXIT-FROM-DEGREE OBJECTIVE STRUCTURED CLINICAL EXAMINATION (OSCE) IN A GULF CONTEXT
(2016 , Master Thesis)This study aimed to evaluate the psychometric properties of the 2nd iteration of an Objective Structured Clinical Examination (OSCE) for graduating pharmacy students in Qatar. A secondary objective of this study was to ... -
Cathepsin B Induced Cardiomyocyte Hypertrophy Requires Activation of The Na+/H+ Exchanger Isoform-1
(2016 , Master Thesis)Multiple studies have demonstrated that proteases, specifically cathepsin B (Cat B) and matrix metalloproteinase-9 (MMP-9) contribute to the remodeling of the extracellular matrix (ECM), a hallmark of cardiac hypertrophy ... -
In Vitro & In Vivo Characterization of Tableted Spray-Congealed Lipid Microparticles for Extended Release of Vildagliptin
(2016 , Master Thesis)Vildagliptin (VG), a drug used for treatment of type 2 diabetes, is soluble in water and currently marketed as an instantaneous release tablet that is administered twice daily. VG is not available as an extended release ... -
Relationship between the Stages of Change and Medication Adherence in Patients with Type 2 Diabetes Mellitus in a Primary Health Care Setting in Qatar
(2016 , Master Thesis)Background: Non-adherence to medications is a major concern among patients with type 2 diabetes mellitus (T2DM). Failure to achieve positive health-related outcomes could be associated with non-adherence. Medication ... -
PROTECTIVE EFFECTS OF METFORMIN IN AN IN VITRO MODEL OF PROTEINURIC KIDNEY DISEASE
(2017 , Master Thesis)Albuminuria, a hallmark of chronic kidney disease (CKD), plays a crucial role in the etiology of CKD. High albumin levels are thought to induce endoplasmic reticulum (ER) stress and activate the AKT pathway, and lead to ... -
PRODUCTION OF LETROZOLE-LOADED MONODISPERSE POLYMERIC-BASED MICROPARTICLES FOR BREAST CANCER THERAPY
(2017 , Master Thesis)Letrozole (LTZ) is effective for the treatment of hormone-receptor-positive breast cancer in postmenopausal women. However, due to its adverse effects this study was designed to investigate the feasibility of producing ... -
Medication-Related Burden among Patients with Chronic Disease Conditions: Perspectives of Patients attending Non-Communicable Disease Clinics in a Primary Healthcare Setting in Qatar
(2017 , Master Thesis)This study aimed to adapt a medication-related burden instrument, the Living with Medicines Questionnaire (LMQ), into the Arabic context, report the psychometric properties of the Arabic version, and assess the burden ... -
Barriers to medication adherence in patients with uncontrolled diabetes in a primary healthcare setting in Qatar: a mixed method triangulation study
(2017 , Master Thesis)Background: In Qatar, 86% of patients with diabetes are uncontrolled. Given that nonadherence to oral drug therapy and psychological insulin resistance are a common phenomenon, one could postulate that patients may not be ... -
Cost-effectiveness analysis of sedatives in the management of neonates undergoing mechanical ventilation in the intensive care setting in Qatar
(2017 , Master Thesis)Background. Neonates with respiratory distress syndrome (RDS), admitted to the neonatal intensive care unit (NICU) at the Women’s Hospital (WH) in Qatar, often require mechanical ventilation (MV) to maintain ventilator ... -
Pharmacoeconomics Evaluation of the Systemic Antifungal Posaconazole for Prophylaxis against Invasive Fungal Infections among Immunocompromised Cancer Patients in Qatar
(2018 , Master Thesis)The immunocompromised hematologic malignancy patients, at the National Center for Cancer Care (NCCCR) in Qatar, receive the antifungal posaconazole for prophylaxis as systemic prophylaxis against invasive fungal infections ... -
Clinical And Pharmacokinetic Evaluation Of Optimal Monitoring Parameters And Sampling Schemes For Vancomycin Therapeutic Drug Monitoring In Qatar
(2018 , Master Thesis)Background: Therapeutic drug monitoring (TDM) of vancomycin has been proven to maximize therapeutic outcomes and minimize toxicity when conducted appropriately. The quality of vancomycin TDM services in many settings ... -
EVALUATION OF PHARMACEUTICAL PRICING AND POLICY IN QATAR AND LEBANON: A COMPARATIVE STUDY OF CARDIOVASCULAR DISEASE MEDICINES
(2018 , Master Thesis)The study aimed to review the pharmaceutical pricing policies and to assess prices, availability, and affordability of essential cardiovascular disease medicines in Qatar and Lebanon across multiple sectors. A thorough ... -
THE EFFECT OF GENETIC AND NON-GENETIC FACTORS ON WARFARIN DOSE VARIABILITY IN QATARI POPULATION
(2018 , Master Thesis)Introduction: Genetic and non-genetic factors were shown to affect warfarin dosing; however, their effect may vary from one population to the other. No previous studies were conducted on the Qatari population to elucidate ...
