College of Pharmacy: المرسلات الحديثة
السجلات المعروضة 1 -- 20 من 58
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DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL CHALCONE ANALOGS AS POTENTIAL THERAPEUTIC AGENTS FOR CASTRATION RESISTANT PROSTATE CANCER
(2021 , Master Thesis)Prostate cancer (PCa) is the second most frequently diagnosed malignancy, as well as a leading cause of cancer-related mortality in men globally. Despite the initial response to hormonal targeted therapy, the majority of ... -
INVESTIGATING THE ROLE OF THE ARYL HYDROCARBON RECEPTOR AND BCL-2 FAMILY PROTEINS IN OVARIAN CANCER STEM CELLS DEVELOPMENT AND CHEMORESISTANCE
(2024 , Dissertation)Gynecological malignancies are a severe threat to female health. Ovarian Cancer (OC), the most lethal gynecological malignancy, is clinically presented with chemoresistance and a higher relapse rate. This could be endorsed ... -
COST-EFFECTIVENESS ANALYSIS OF SUBCUTANEOUS DARATUMUMAB VERSUS INTRAVENOUS DARATUMUMAB IN NEWLY DIAGNOSED MULTIPLE MYELOMA
(2024 , Master Thesis)Background: Both subcutaneous (SC) and intravenous (IV) formulations of Daratumumab (Dara) are used, in combination with lenalidomide, bortezomib, and dexamethasone (VRd), for treating newly diagnosed multiple myeloma ... -
ECONOMIC EVALUATION OF DIABETIC NEUROPATHY MONOTHERAPY FOLLOWED BY COMBINATION THERAPY TREATMENT
(2024 , Master Thesis)Objective: To summarize the literature evidence towards the efficacy and safety of diabetic neuropathy (DNP) treatments, and to assess the cost-effectiveness among the DNP treatment regimens in Qatar, including the use of ... -
CURCUMIN-CONJUGATED CHITOSAN OLIGOMERS DERIVED FROM MICROWAVE IRRADIATION FOR NANOFORMULATION IN COLON CANCER TREATMENT
(2024 , Master Thesis)Colon cancer remains as one of the leading causes of deaths worldwide, whilst current treatment options are not optimal. Chemotherapy is the mainstay in cancer therapy but is associated with severe side effects. Some ... -
APPLICATION OF SOLID DISPERSION IN CONJUNCTION WITH 3D PRINTING FOR PERSONALIZED MEDICINE
(2024 , Master Thesis)Poorly water-soluble drugs accounts for 40% of the newly discovered APIs due to their lipophilic nature. Hence, to benefit from the therapeutic effects of such drugs requires administration of higher doses. However, ... -
THE EFFECT OF OBESITY ON RIVAROXABAN PHARMACOKINETICS AND PHARMACODYNAMICS
(2024 , Dissertation)Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a prevalent condition that is associated with high rates of morbidity and mortality worldwide. Similarly, atrial fibrillation ... -
The Cytotoxicity Of “Al-Siddir” Tree “Ziziphus Spina Christi” Methanolic Leaves Extract on Her-2 Positive Breast Cancer
(2024 , Master Thesis)HER-2 positive is a subtype of breast cancer that acquires poor prognosis and low survival rates. Targeted therapy is one of the main approaches that are used for the treatment of HER-2-positive breast cancer. However, it ... -
Developing Pharmacist-Led Anticoagulation Clinics in Primary Care Settings: A Multi-Phase Mixed-Methods Study
(2024 , Master Thesis)Background: Primary care is an integral part of the healthcare system. Patients have better accessibility and continuity of care. However, studies have reported low-quality warfarin management in these settings. Pharmacist-led ... -
Nano Liposomal Formulation for A Novel Chalcone Compound as A Potential Anticancer Delivery System for Triple-Negative Breast Cancer
(2024 , Master Thesis)Triple negative breast cancer is the most aggressive type of breast malignancy accounting for 15-20% of all breast cancer cases. Treatment of TNBC remains limited, with a high risk of relapse and metastasis to other organs. ... -
Development of A Novel Liposomal Formulation of a Pyridine Chalcone Analogue for HER-2 Positive Breast Cancer
(2024 , Master Thesis)Breast cancer is the most prevalent cancer in women and the fifth leading cause of death due to cancer worldwide. Human epidermal growth factor receptor-2 (HER-2) is an oncoprotein that is overexpressed in 25-30% of breast ... -
DRUG SURVIVAL OF DIFFERENT BIOLOGICS IN PSORIATIC PATIENTS - EVIDENCE SYNTHESIS AND HISTORICAL COHORT STUDY
(2023 , Master Thesis)Biologic therapies have revolutionized the treatment of psoriasis, providing high levels of efficacy and safety. However, the choice of the appropriate therapy for each patient remains a challenge. The primary objective ... -
Trends and Appropriateness of Sodium-glucose Co-transporter 2 Inhibitors Use in Qatar
(2023 , Master Thesis)Background: Sodium glucose co-transporter 2 inhibitors (SGLT2is) are the most recently approved class of oral antidiabetic drugs (ADDs). The objective of this study was to explore the trends in the use of SGLT2is compared ... -
Ethanol-Based Proliposomes Incorporating Dexamethasone for The Treatment of COVID-19 Acute Respiratory Distress Syndrome (ARDS) Using Medical Nebulizers
(2023 , Master Thesis)Background/Objective: Systemic dexamethasone has demonstrated mortality reduction in COVID-19-related acute respiratory distress syndrome (ARDS). The aim of this study is to use ethanol-based proliposome technology to ... -
Anticancer Activity of Neosetophomone-B, a Fungal Secondary Metabolite, Against Hematological Malignancies
(2023 , Dissertation)Anticancer Activity of Neosetophomone-B, a Fungal Secondary Metabolite, Against Hematological Malignancies downregulation, and p21 and p27 upregulation were observed in NSP-B-treated leukemia, lymphoma, and myeloma cells. ... -
HYPERTENSION MANAGEMENT AND PRESCRIBING PRACTICES IN PRIMARY HEALTHCARE SETTINGS IN QATAR: A MULTI-METHODS
(2023 , Master Thesis)Background: The use of antihypertensive medications controls blood pressure (BP) and reduces the incidence of complications. This study explored the prescribing patterns and trends of antihypertensive medications utilization, ... -
EXPLORATION OF THE APPLICATION OF PHARMACOGENETICS IN THE MANAGEMENT OF DEPRESSION
(2023 , Master Thesis)Genetic factors have been reported as playing an important role in the treatment efficacy of antidepressants (ADs). Studies report up to 55 % of patients experience AD treatment failure. The aim of this research was to ... -
IMPACT OF SGLT2 INHIBITORS ON CKD PROGRESSION IN DIABETIC PATIENTS IN QATAR A RETROSPECTIVE COHORT STUDY
(2023 , Master Thesis)Background: The risk of end-stage renal disease rises is based on the estimated glomerular filtration rate (eGFR) reduction. Even though multiple large-scale clinical trials have demonstrated the preventive benefits of ... -
SUCCINYLATED CURCUMIN LOADED IN MANNOSYLATED CHITOSAN NANOPARTICLES FOR COLON CANCER THERAPY
(06-2 , Master Thesis)Colon cancer (CRC) is the second leading cause of death and the third most diagnosed type worldwide. Although curcumin (CUR) has potent anticancer activity, it suffers from low solubility, bioavailability, and instability. ... -
THE EFFECT OF NATURAL AND SYNTHETIC COMPOUNDS ON COLORECTAL CANCER: IN VITRO AND IN VIVO STUDIES
(06-2 , Master Thesis)Colorectal cancer (CRC) is one of the deadliest malignancies in the world. Despite improved treatment, CRC incidence and mortality rates have been increasing lately. Current conventional therapies are associated with severe ...
