The Effect of Bariatric Surgery on PAI-1 Levels: A Systematic Review and Meta-analysis
| Author | Jamialahamdi, Tannaz |
| Author | Mirhadi, Elaheh |
| Author | Almahmeed, Wael |
| Author | Sukhorukov, Vasily N. |
| Author | Eid, Ali H. |
| Author | Salehabadi, Sepideh |
| Author | Sahebkar, Amirhossein |
| Available date | 2024-10-08T10:58:24Z |
| Publication Date | 2024-01-01 |
| Publication Name | Obesity Surgery |
| Identifier | http://dx.doi.org/10.1007/s11695-024-07473-1 |
| Citation | Jamialahamdi, T., Mirhadi, E., Almahmeed, W. et al. The Effect of Bariatric Surgery on PAI-1 Levels: A Systematic Review and Meta-analysis. OBES SURG (2024). https://doi.org/10.1007/s11695-024-07473-1 |
| ISSN | 09608923 |
| Abstract | The purpose of this meta-analysis was to determine the effect of bariatric surgery on circulating PAI-1. The meta-analysis was provided by comprehensive meta-analysis (CMA) V4 software. Meta-analysis of 33 studies showed a significant decrease in circulating PAI-1 after bariatric surgery (p < 0.001). A significant reduction was observed for two types of surgery) (p < 0.001 for LSG and p < 0.001 for RYGB). Furthermore, there was a significant change in circulating PAI-1 based on the follow-up duration (p < 0.001 for follow-up < 12 months and p < 0.001 for follow-up ≥ 12). We showed that bariatric surgery changed PAI-1 level significantly and changes in BMI after surgery were not related to PAI-1 alteration. Furthermore, this result was consistent based on follow-up duration and type of surgery. |
| Sponsor | This work was supported by the Russian Science Foundation (Grant # 23–65-10014). |
| Language | en |
| Publisher | Springer Nature |
| Subject | Fibrinolysis Inflammation Metabolic surgery Obesity PAI-1 |
| Type | Article |
| ESSN | 1708-0428 |
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