Biomedical Research Center: Recent submissions
Now showing items 161-180 of 740
-
Biological applications of imiquimod analogues: An update (Review)
( Spandidos Publications , 2023 , Article Review)The last decade witnessed intensive efforts in drug discovery and the emergence of thousands of molecules with potential for use as therapeutic targets. However, only a few hundred of these molecules reached the stage of ... -
3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities
( Elsevier , 2023 , Article Review)Repairing significant bone defects remains a critical challenge, raising the clinical demand to design novel bone biomaterials that incorporate osteogenic and angiogenic properties to support the regeneration of vascularized ... -
Biochemical and cellular basis of oxidative stress: Implications for disease onset
( Wiley , 2023 , Article Review)Cellular oxidation–reduction (redox) systems, which encompass pro- and antioxidant molecules, are integral components of a plethora of essential cellular processes. Any dysregulation of these systems can cause molecular ... -
The QChip1 knowledgebase and microarray for precision medicine in Qatar
( Nature Research , 2022 , Article)Risk genes for Mendelian (single-gene) disorders (SGDs) are consistent across populations, but pathogenic risk variants that cause SGDs are typically population-private. The goal was to develop "QChip1," an inexpensive ... -
Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications
( Nature Research , 2022 , Article)COVID-19 complications still present a huge burden on healthcare systems and warrant predictive risk models to triage patients and inform early intervention. Here, we profile 893 plasma proteins from 50 severe and 50 ... -
First characterisation of antimicrobial susceptibility and resistance of Neisseria gonorrhoeae isolates in Qatar, 2017-2020
( Public Library of Science , 2022 , Article)Limited data are available regarding antimicrobial resistance in Neisseria gonorrhoeae strains circulating in WHO Eastern Mediterranean Region (EMR). We investigated the antimicrobial susceptibility/resistance of N. ... -
Detection of Antinuclear Antibodies Targeting Intracellular Signal Transduction, Metabolism, Apoptotic Processes and Cell Death in Critical COVID-19 Patients
( Universita Cattolica del Sacro Cuore , 2022 , Article)Background and Objectives: The heterogeneity of the coronavirus disease of 2019 (COVID-19) lies within its diverse symptoms and severity, ranging from mild to lethal. Acute respiratory distress syndrome (ARDS) is a leading ... -
Statistical methods and resources for biomarker discovery using metabolomics.
( BMC , 2023 , Article Review)Metabolomics is a dynamic tool for elucidating biochemical changes in human health and disease. Metabolic profiles provide a close insight into physiological states and are highly volatile to genetic and environmental ... -
A single tube system for the detection of Mycobacterium tuberculosis DNA using gold nanoparticles based FRET assay
( Elsevier , 2017 , Article)The global combat against MTB is limited by challenges in accurate affordable detection. In this study, a rapid, affordable, single tube system for detection of unamplified MTB16s rDNA was developed. Utilizing a AuNP based ... -
Enteric pathogens modulate metabolic homeostasis in the Drosophila melanogaster host
( Elsevier , 2022 , Article)On quotidian basis, living beings work out an armistice with their microbial flora and a scuffle with invading pathogens to maintain a normal state of health. Although producing virulence factors and escaping the host's ... -
Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region
( Elsevier , 2022 , Article)Acute gastroenteritis is the cause of considerable mortality and morbidity worldwide, particularly among children under five years in underdeveloped countries. Most acute gastroenteritis (AGE) cases are attributed to viral ... -
Comparative analysis of within-host diversity among vaccinated COVID-19 patients infected with different SARS-CoV-2 variants
( Elsevier , 2022 , Article)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly evolving RNA virus that mutates within hosts and exists as viral quasispecies. Here, we evaluated the within-host diversity among vaccinated and ... -
Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling
( Elsevier , 2017 , Article)Aortic valve diseases are among the most common cardiovascular defects. Since a non-functioning valve results in disturbed blood flow conditions, the diagnosis of such defects is based on identification of stenosis via ... -
Will influenza A(H3N8) cause a major public health threat?
( Elsevier , 2022 , Article)The diversity of zoonotic influenza viruses and their ability to cross the species barrier has always been alarming and requires continuous surveillance in both human and animal populations. Avian A(H3N8) influenza viruses ... -
Intake of Caffeine Containing Sugar Diet Remodels Gut Microbiota and Perturbs Drosophila melanogaster Immunity and Lifespan
( Elsevier , 2023 , Article)The diet-microbiome-immunity axis is one among the many arms that draw up the “we are what we intake” proclamation. As such, studies on the effect of food and beverage intake on the gut environment and microbiome and on ... -
Role of Graphene Oxide in Bacterial Cellulose−Gelatin Hydrogels for Wound Dressing Applications
( American Chemical Society , 2022 , Article)Biopolymer-based hydrogels have several advantages, including robust mechanical, high biocompatibility, and excellent properties. These hydrogels can be ideal wound dressing materials and advantageous to repair and regenerate ... -
The stereological, immunohistological, and gene expression studies in an infected ischemic wound in diabetic rats treated by human adipose-derived stem cells and photobiomodulation
( Institute for Ionics , 2023 , Article)We investigated the impacts of photobiomodulation (PBM) and human allogeneic adipose-derived stem cells (ha-ADS) together and or alone applications on the stereological parameters, immunohistochemical characterizing of M1 ... -
Multifunctional Bioactive Scaffolds from ARX- g-(Zn@rGO)-HAp for Bone Tissue Engineering: In Vitro Antibacterial, Antitumor, and Biocompatibility Evaluations
( American Chemical Society , 2022 , Article)Advanced biomaterials are required with enhanced antibacterial and anticancer activities to obtain desirable biocompatibility during and after scaffold implantation in tissue engineering. Here, we report the development ... -
Zinc oxide loaded chitosan-elastin-sodium alginate nanocomposite gel using freeze gelation for enhanced adipose stem cell proliferation and antibacterial properties
( Elsevier , 2023 , Article)Hydrogels have been the material of choice for regenerative medicine applications due to their biocompatibility that can facilitate cellular attachment and proliferation. The present study aimed at constructing a porous ... -
Bioactive scaffold (sodium alginate)-g-(nHAp@SiO2@GO) for bone tissue engineering
( Elsevier , 2022 , Article)Globally, people suffering from bone disorders are steadily increasing and bone tissue engineering is an advanced approach to treating fractured and defected bone tissues. In this study, we have prepared polymeric nanocomposite ...
