Biomedical Research Center: Recent submissions
Now showing items 21-40 of 878
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Thymol's Nanoencapsulation Reduces its Toxicity in Human Cells and Zebrafish Embryos
( Saudi Pharmacy Association (SPS)- Ministry of Health , 2025 , Conference)Thymol, a monoterpenoid and a major bioactive constituent of essential oils (EOs) derived from the plants of Lamiacea family such as Thyme, garnered wider research interest for its diverse biological activity and industrial ... -
PBA 23: Nanoencapsulation of Thymol Mitigates its Toxicity in Cells and Zebrafish Embryos
( College of Education, Qatar University , 2025 , Conference)Thymol, a monoterpenoid and a major boactive constituent of essential oils (EOs) derived from the plants of Lamiacea species such as Thyme, has garnered wider research interest for its diverse pharmaceutical, food, and ... -
Human primary mesenchymal stem cells fail to recover full osteogenic differentiation potential following washout of electronic cigarette aerosol extracts.
( Oxford University Press , 2025 , Article)Electronic cigarettes (e-cigarettes) are promoted as safer alternatives to combustible cigarettes. However, the health burden and effects of their long-term use remain unidentified. This study evaluates the extent and ... -
Anti-amyloid monoclonal antibody therapies in Alzheimer’s disease – a scoping review
( Elsevier , 2025 , Article Review)Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting millions worldwide, and with advancements in the medical field, Anti-amyloid monoclonal antibodies (AA mAbs) targeting amyloid-β have emerged ... -
Therapeutic Insights into Rubus ulmifolius Schott Leaf Extract: In Vitro Antifungal, Enzyme Inhibition, and Anticancer Activities Integrated with Network Pharmacology and Molecular Docking Analyses of Colorectal and Ovarian Cancer
( MDPI , 2025 , Article)Background/Objectives: This study evaluated the antifungal, enzyme inhibitory, and anticancer properties of the ethyl acetate (EtOAc) leaves extract of Rubus ulmifolius Schott using in vitro assays and in silico analysis. ... -
Evaluating the ecotoxicity of polymer-coated SPIONs for scale inhibition using a zebrafish embryo model
( Elsevier , 2026 , Article)Superparamagnetic iron oxide nanoparticles (SPIONs) are increasingly explored as sustainable scale inhibitors in oilfield operations, offering high efficiency, magnetic recoverability, and reduced chemical discharge. This ... -
Edaravone: Advances on cytoprotective effects, pharmacological properties, and mechanisms of action
( Elsevier , 2025 , Article Review)Neurological diseases often lead to life-altering consequences, underscoring the urgent need for therapies that can reverse or mitigate their effects. Effective management of neurological disorders necessitates a thorough ... -
Nanoencapsulation mitigates the toxicity of thymol in human cells and zebrafish embryos
( Taylor and Francis Group , 2025 , Article)This study evaluated the cytotoxicity of free thymol (FT) and thymol encapsulated in monolayer (MNCT) and layer-by-layer nanocapsules (LNCT) in normal human (MCF10A, HaCaT, HdFn), and cancer cell lines (MDA-MB-231, A549, ... -
Bariatric metabolic surgery and cancer risk: Target trial emulation using iterative time distribution matching.
( The Association of Basic Medical Sciences , 2025 , Article)Bariatric metabolic surgery (BMS) is a common intervention for severe obesity, yet its effects on cancer risk remain unclear. Observational studies and meta-analyses yield inconsistent findings, while randomized controlled ... -
Advancing targeted therapy for colorectal cancer: harnessing ligand-directed enzyme prodrug therapy for highly specific interventions
( Frontiers Media SA , 2025 , Article)Colorectal cancer (CRC) is a significant global health burden, ranking as the third most frequently diagnosed cancer and a leading cause of cancer-related mortality. Current therapeutic modalities face challenges in advanced ... -
Oscillatory Disturbed Flow Enhances Inflammatory and Oxidative Stress Markers in Endothelial Cells
( MDPI , 2025 , Article)Hemodynamics significantly impact the biology of endothelial cells (ECs) lining the blood vessels. ECs are exposed to various hemodynamic forces, particularly frictional shear stress from flowing blood. While physiological ... -
Finite Element Analysis of Self Expanding Transcatheter Aortic Valves reveals Increased Stent contact Pressure is Associated with Higher Conduction Abnormality Risk
( The Royal Society , 2025 , Conference)For transcatheter aortic valve implantation (TAVI), selecting optimal valve size and implantation depth within aortic root is crucial for preventing complications, such as conduction problems and paravalvular leak. ... -
Studying Cardiovascular Mechanobiology in Development and Disease with Zebrafish
( The Royal Society , 2025 , Conference)Zebrafish is a practical vertebrate model to investigate human cardiovascular disorders due to several advantages such as close genetic resemblance, cardiac physiological similarities, low maintenance costs, high throughput ... -
Effectiveness of ChAdOx1 nCoV-19 (Vaxzevria) primary series vaccine against SARS-CoV-2 beta and delta variants: a nationwide study
( Springer Nature , 2025 , Article)Background: This study assessed the real-world effectiveness of the ChAdOx1 nCoV-19 vaccine in adults against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, symptomatic infection, and severe ... -
Assessing healthy vaccinee effect in COVID-19 vaccine effectiveness studies: a national cohort study in Qatar.
( National Center for Biotechnology Information , 2025 , Article)This study investigated the presence of the healthy vaccinee effect-the imbalance in health status between vaccinated and unvaccinated individuals-in two rigorously conducted COVID-19 vaccine effectiveness studies involving ... -
Artificial Intelligence in Biomedical Sciences: A Scoping Review
( Frontiers , 2025 , Article)Background: Artificial intelligence (AI) is increasingly playing important roles in healthcare diagnosis, treatment, monitoring, and prevention of diseases. Despite this widespread implementation of AI in biomedical sciences, ... -
Qatar’s National Expanded Metabolic Newborn Screening Program: Incidence and Outcomes
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background: Newborn screening is an essential public health strategy that aims to detect a range of conditions, including inborn errors of metabolism, in neonates shortly after birth. The timely identification is crucial ... -
Tyrosine kinase inhibitors and their promising role in treating diabetic retinopathy and other retinal vascular diseases: overview of their routes of administration, pharmacokinetics, formulations, and drug delivery applications
( Taylor and Francis , 2025 , Article)Introduction: Tyrosine Kinase Inhibitors (TKIs) are emerging as a promising alternative to protein-based anti-vascular endothelial growth factors (anti-VEGF) in treating diabetic retinopathy (DR) and other retinal vascular ... -
Environmental Amoxicillin Exposure Induces Cardiotoxicity in Zebrafish Embryos: A Comprehensive Assessment of Heart Function and Molecular Responses
( MDPI , 2025 , Article)Background/Objectives. Environmental pollution poses a significant threat to human health, primarily through the degradation of natural ecosystems. Emerging organic contaminants (EOCs), such as pharmaceuticals like ... -
N-Lactoyl Amino Acids: Emerging Biomarkers in Metabolism and Disease
( Wiley , 2025 , Article)N-lactoyl amino acids (Lac-AA) form an emerging class of metabolites that have gained significant attention in recent years due to their ubiquitous presence in different biological systems and potential roles in various ...
