Browsing by Author "Nasrallah, Gheyath K."
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Addressing bias in the definition of SARS-CoV-2 reinfection: implications for underestimation
Chemaitelly, Hiam; Ayoub, Houssein H.; Tang, Patrick; Yassine, Hadi M.; Al Thani, Asmaa A.; Hasan, Mohammad R.; Coyle, Peter; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul-Rahim, Hanan F.; Nasrallah, Gheyath K.; Al-Kuwari, Mohamed Ghaith; Butt, Adeel A.; Al-Romaihi, Hamad Eid; Al-Thani, Mohamed H.; Al-Khal, Abdullatif; Bertollini, Roberto; Abu-Raddad, Laith J.... more authors ... less authors ( Frontiers Media , 2024 , Article)Introduction: Reinfections are increasingly becoming a feature in the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, accurately defining reinfection poses methodological ... -
Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa
Majdalawieh, Amin F.; Fayyad, Muneera W.; Nasrallah, Gheyath K. ( Taylor & Francis , 2017 , Article)Over the past two decades, studies have documented the wide-range anti-cancer effects of Nigella sativa, known as black seed or black cumin. Thymoquinone (TQ), its major active ingredient, has also been extensively studied ... -
Antibody-dependent enhancement of SARS-CoV-2, the impact of variants and vaccination
Thomas, Swapna; Smatti, Maria K.; Mohammad AlKhatib, Hebah Atef; Tayyar, Yaman; Nizar, Muna; Zedan, Hadeel T.; Ouhtit, Allal; Althani, Asmaa A.; Nasrallah, Gheyath K.; Yassine, Hadi M.... more authors ... less authors ( Taylor and Francis Group , 2025 , Article)This study characterized antibody-dependent enhancement (ADE) in serum samples from individuals exposed to SARS-CoV-2 via infection or vaccination and evaluated its association with SARS-CoV-2 variants (Wuhan and Omicron), ... -
Assessment of Broadly Reactive Responses in Patients With MERS-CoV Infection and SARS-CoV-2 Vaccination
Zedan, Hadeel T.; Smatti, Maria K.; Thomas, Swapna; Nasrallah, Gheyath K.; Afifi, Nahla M.; Hssain, Ali Ait; Abu Raddad, Laith J.; Coyle, Peter V.; Grivel, Jean Charles; Almaslamani, Muna A.; Althani, Asmaa A.; Yassine, Hadi M.... more authors ... less authors ( American Medical Association , 2023 , Article)Importance: In the ongoing COVID-19 pandemic, there remain unanswered questions regarding the nature and importance of the humoral immune response against other coronaviruses. Although coinfection of the Middle East ... -
Assessment of the Neutralizing Antibody Response of BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines in Naïve and Previously Infected Individuals: A Comparative Study
Shurrab, Farah M.; Al-Sadeq, Duaa W.; Abou-Saleh, Haissam; Al-Dewik, Nader; Elsharafi, Amira E.; Hamaydeh, Fatima M.; Abo Halawa, Bushra Y.; Jamaleddin, Tala M.; Abdul Hameed, Huda M.; Nizamuddin, Parveen B.; Amanullah, Fathima Humaira; Daas, Hanin I.; Abu-Raddad, Laith J.; Nasrallah, Gheyath K.... more authors ... less authors ( MDPI , 2022 , Report)The currently authorized mRNA COVID-19 vaccines, Pfizer-BNT162b2 and Moderna-mRNA-1273, offer great promise for reducing the spread of the COVID-19 by generating protective immunity against SARS-CoV-2. Recently, it was ... -
Bivalent mRNA-1273.214 vaccine effectiveness against SARS-CoV-2 omicron XBB* infections
Chemaitelly, Hiam; Ayoub, Houssein H.; AlMukdad, Sawsan; Faust, Jeremy S.; Tang, Patrick; Coyle, Peter; Yassine, Hadi M.; Al Thani, Asmaa A.; Al-Khatib, Hebah A.; Hasan, Mohammad R.; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar H.; Latif, Ali N.; Shaik, Riyazuddin M.; Abdul-Rahim, Hanan F.; Nasrallah, Gheyath K.; Al-Kuwari, Mohamed G.; Butt, Adeel A.; Al-Romaihi, Hamad E.; Al-Thani, Mohamed H.; Al-Khal, Abdullatif; Bertollini, Roberto; Abu-Raddad, Laith J.... more authors ... less authors (2023 , Article)In October of 2022, Qatar introduced COVID-19 bivalent vaccination for persons ≥ 12 years using the 50-μg mRNA-1273.214 vaccine combining SARS-CoV-2 ancestral and omicron BA.1 strains.1 We estimated this vaccine’s effectiveness ... -
BNT162b2 antigen dose and SARS-CoV-2 omicron infection in adolescents
Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Yassine, Hadi M.; Al Thani, Asmaa A.; Al-Khatib, Hebah A.; Hasan, Mohammad R.; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul-Rahim, Hanan F.; Nasrallah, Gheyath K.; Al-Kuwari, Mohamed Ghaith; Al-Romaihi, Hamad Eid; Butt, Adeel A.; Al-Thani, Mohamed H.; Al-Khal, Abdullatif; Bertollini, Roberto; Abu-Raddad, Laith J.... more authors ... less authors ( Elsevier , 2023 , Other)COVID-19 vaccine antigen dose might affect protection against SARS-CoV-2 infection,1, 2 but direct evidence to quantify this effect is absent. We conducted a matched, retrospective, cohort study using a regression ... -
Burden and disease pathogenesis of influenza and other respiratory viruses in diabetic patients
Swapna, Thomas; Ouhtit, Allal; Al Khatib, Hebah A.; Eid, Ali H.; Mathew, Shilu; Nasrallah, Gheyath K.; Emara, Mohamed M.; Al Maslamani, Muna A.; Yassine, Hadi M.... more authors ... less authors ( Elsevier , 2022 , Article Review)Over the past two decades, diabetes mellitus (DM) has been receiving increasing attention among autoimmune diseases. The prevalence of type 1 and type 2 diabetes has increased rapidly and has become one of the leading ... -
Characterizing the effective reproduction number during the COVID-19 pandemic: Insights from Qatar's experience
Bsat, Raghid; Chemaitelly, Hiam; Coyle, Peter; Tang, Patrick; Hasan, Mohammad R.; Kanaani, Zaina Al; Kuwari, Einas Al; Butt, Adeel A.; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Nasrallah, Gheyath K.; Benslimane, Fatiha M.; Khatib, Hebah A.Al; Yassine, Hadi M.; Kuwari, Mohamed G.Al; Romaihi, Hamad Eid Al; Al-Thani, Mohamed H.; Khal, Abdullatif Al; Bertollini, Roberto; Abu-Raddad, Laith J.; Ayoub, Houssein H.... more authors ... less authors ( Edinburgh University Global Health Society , 2022 , Article)Background The effective reproduction number, Rt, is a tool to track and understand pandemic dynamics. This investigation of Rt estimations was conducted to guide the national COVID-19 response in Qatar, from the onset of ... -
Comparable antibody levels in heterologous and homologous mRNA COVID-19 vaccination, with superior neutralizing and IgA antibody responses in mRNA homologous boosting
Salma, Younes; Nicolai, Eleonora; Younes, Nadin; Pieri, Massimo; Bernardini, Sergio; Nizamuddin, Parveen B.; Al-Sadeq, Duaa W.; Daas, Hanin I.; Ismail, Ahmed; Yassine, Hadi M.; Abu-Raddad, Laith J.; Nasrallah, Gheyath K.... more authors ... less authors ( Elsevier , 2024 , Article)BackgroundPriming with two doses of AZD1222 (Oxford-AstraZeneca; ChAd) followed by a third mRNA vaccine boosting is considered in several countries, yet comparisons between heterologous and homologous booster efficacy ... -
Comprehensive analysis of human coronavirus antibody responses in ICU and non-ICU COVID-19 patients reveals IgG3 against SARS-CoV-2 spike protein as a key biomarker of disease severity
Ali, Fatma H.; Gentilcore, Giusy; Al-Jighefee, Hadeel T.; Taleb, Sara Ahmad; Hssain, Ali Ait; Qotba, Hamda A.; Al Thani, Asmaa A.; Abu Raddad, Laith J.; Nasrallah, Gheyath K.; Grivel, Jean Charles; Yassine, Hadi M.... more authors ... less authors ( Microbiology Society , 2025 , Article)Introduction. Pre-existing immunity to human coronaviruses (HCoVs) may shape the immune response in COVID-19 patients. Increasing evidence suggests that immune cross-reactivity between SARS-CoV-2 and other coronaviruses ... -
Correction to: Co-prevalence of human Papillomaviruses (HPV) and Epstein–Barr virus (EBV) in healthy blood donors from diverse nationalities in Qatar
Gupta, Ishita; Nasrallah, Gheyath K.; Sharma, Anju; Jabeen, Ayesha; Smatti, Maria K.; Al-Thawadi, Hamda A.; Sultan, Ali A.; Alkhalaf, Moussa; Vranic, Semir; Moustafa, Ala Eddin Al... more authors ... less authors ( BMC , 2020 , Article)Correction to: Cancer Cell Int (2020) 20:107 https://doi.org/10.1186/s12935-020-01190-2 -
Covid-19 Vaccine Protection among Children and Adolescents in Qatar.
Chemaitelly, Hiam; AlMukdad, Sawsan; Ayoub, Houssein H; Altarawneh, Heba N; Coyle, Peter; Tang, Patrick; Yassine, Hadi M; Al-Khatib, Hebah A; Smatti, Maria K; Hasan, Mohammad R; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar H; Latif, Ali N; Shaik, Riyazuddin M; Abdul-Rahim, Hanan F; Nasrallah, Gheyath K; Al-Kuwari, Mohamed G; Al-Romaihi, Hamad E; Butt, Adeel A; Al-Thani, Mohamed H; Al-Khal, Abdullatif; Bertollini, Roberto; Abu-Raddad, Laith J... more authors ... less authors ( Massachusetts Medical Society , 2022 , Article)The BNT162b2 vaccine against coronavirus disease 2019 (Covid-19) has been authorized for use in children 5 to 11 years of age and adolescents 12 to 17 years of age but in different antigen doses. We assessed the real-world ... -
The Current Status of Cytomegalovirus (CMV) Prevalence in the MENA region: a systematic review
Al Mana, Hassan; Yassine, Hadi M.; Youne, Nadin N.; Al-Mohannadi, Anjud; Al-Sadeq, Duaa W.; Alhababi, Dalal; Nasrallah, Gheyath K.... more authors ... less authors ( MDPI , 2019 , Article)Human cytomegalovirus (CMV) is a highly prevalent herpesvirus worldwide. According to the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO), CMV infects people of all ages, and by ... -
A customizable multiplex protein microarray for antibody testing and its application for tick-borne and other infectious diseases
Krishnamurthy, Hari Krishnan; Jayaraman, Vasanth; Krishna, Karthik; Wang, Tianhao; Bei, Kang; Changalath, Chithra; Matilda, Shiny; Rai, Alex J.; Welc-Falęciak, Renata; Pawełczyk, Agnieszka; Blanton, Lucas S.; Chrdle, Aleš; Fořtová, Andrea; Růžek, Daniel; Nasrallah, Gheyath K.; Abu-Raddadi, Laith J.; Al-Sadeq, Duaa W.; Abdallah, Marah Abed Alhakim; Lilleri, Daniele; Fornara, Chiara; D’Angelo, Piera; Furione, Milena; Söderlund-Venermo, Maria; Hedman, Klaus; Chochlakis, Dimosthenis; Makridaki, Eirini; Ntoula, Artemis; Psaroulaki, Anna; Escárcega-Ávila, Angélica; Rajasekaran, John J.... more authors ... less authors ( Springer Nature , 2025 , Article)Tick-borne infections are the most common vector-borne diseases in the USA. Ticks harbor and transmit several infections with Lyme disease being the most common tickborne infection in the US and Europe. Lack of awareness ... -
Demographics and Epidemiology of Hepatitis B in the State of Qatar: A Five-Year Surveillance-Based Incidence Study
Al Romaihi, Hamad E.; Ganesan, Nandakumar; Farag, Elmoubasher A.; Smatti, Maria K.; Nasrallah, Gheyath K.; Himatt, Sayed M.; Derbala, Moutaz F.; Alshamali, Maha; Mahadoon, Lylu K.; Khogali, Hayat S.; Sallam, Mohamed; Al Thani, Asmaa A.; Al Thani, Mohammed; Al Kaabi, Saad; Yassine, Hadi M.... more authors ... less authors ( MDPI , 2019 , Article)Background: Expatriates represent >80% of Qatar’s population, mostly arriving from countries in Africa and Asia that are endemic with many diseases. This increases the risk for introducing new pathogens into the country ... -
Detection and Genotyping of Torque Teno Virus (TTV) in Healthy Blood Donors and Patients Infected With HBV or HCV in Qatar
AbuOdeh, Raed; Al-Mawlawi, Naema; Al-Qahtani, Ahmed; Bohol, Marie Fe F.; Al-Ahdal, Mohammed N.; Hasan, Haydar A.; AbuOdeh, Lamees; Nasrallah, Gheyath K.... more authors ... less authors ( Wiley Periodicals, Inc , 2015 , Article)Torque Teno virus (TTV) has been associated with non A–G hepatitis. The goal of this study was to estimate the infection rates and genotypic characteristics of TTV in the State of Qatar. A total of 644 blood samples ... -
Detection and Phylogenetic Analysis of Human Pegivirus (GBV-C) Among Blood Donors and Patients Infected With Hepatitis B Virus (HBV) in Qatar
AbuOdeh, Raed O.; Al-Absi, Enas; Ali, Nadima H.; Khalili, Makiyeh; Al-Mawlawi, Naema; Hadwan, Tameem A.; Al Thani, Asmaa A.; Nasrallah, Gheyath K.... more authors ... less authors ( Wiley , 2015 , Article)Human Pegivirus (HPgV), formerly GB virus-C/ Hepatitis G virus (GBV-C/HGV), collectively known as GBV-C, is widely spread and has been reported to be associated with non-A–E hepatitis. To our knowledge, no previous ... -
Diagnostic Efficiency of Three Fully Automated Serology Assays and Their Correlation with a Novel Surrogate Virus Neutralization Test in Symptomatic and Asymptomatic SARS-COV-2 Individuals
Younes, Salma; Al-Jighefee, Hadeel; Shurrab, Farah; Al-Sadeq, Duaa W.; Younes, Nadin; Dargham, Soha R.; Al-Dewik, Nader; Qotba, Hamda; Syed, Mohamed; Alnuaimi, Ahmed; Yassine, Hadi M.; Tang, Patrick; Abu-Raddad, Laith J.; Nasrallah, Gheyath K.... more authors ... less authors ( MDPI , 2020 , Article)Abstract: To support the deployment of serology assays for population screening during the COVID-19 pandemic, we compared the performance of three fully automated SARS-CoV-2 IgG assays: Mindray CL-900i® (target: spike [S] ... -
Differential protection against SARS-CoV-2 reinfection pre- and post-Omicron
Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Hasan, Mohammad R.; Yassine, Hadi M.; Al Thani, Asmaa A.; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul-Rahim, Hanan F.; Nasrallah, Gheyath K.; Al-Kuwari, Mohamed Ghaith; Butt, Adeel A.; Al-Romaihi, Hamad Eid; Al-Thani, Mohamed H.; Al-Khal, Abdullatif; Bertollini, Roberto; Abu-Raddad, Laith J.... more authors ... less authors ( Springer Nature , 2025 , Article)The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly evolved over short timescales, leading to the emergence of more transmissible variants such as Alpha and Delta1, 2–3. The arrival of the Omicron ...