Browsing by Author "Tricarico, Paola Maura"
Now showing items 1-11 of 11
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Aquaporins Are One of the Critical Factors in the Disruption of the Skin Barrier in Inflammatory Skin Diseases
Tricarico, Paola Maura; Mentino, Donatella; De Marco, Aurora; Del Vecchio, Cecilia; Garra, Sabino; Cazzato, Gerardo; Foti, Caterina; Crovella, Sergio; Calamita, Giuseppe... more authors ... less authors ( MDPI , 2022 , Article Review)The skin is the largest organ of the human body, serving as an effective mechanical barrier between the internal milieu and the external environment. The skin is widely considered the first-line defence of the body, with ... -
Autoinflammation in Syndromic Hidradenitis Suppurativa: The Role of AIM2.
Moltrasio, Chiara; Cagliani, Rachele; Sironi, Manuela; Clerici, Mario; Pontremoli, Chiara; Maronese, Carlo Alberto; Tricarico, Paola Maura; Crovella, Sergio; Marzano, Angelo Valerio... more authors ... less authors ( MDPI , 2023 , Report)AIM2 is a key cytoplasmatic pathogen-sensor that detects foreign DNA from viruses and bacteria; it can also recognize damaged or anomalous presence of DNA, promoting inflammasome assembly and activation with the secretion ... -
Clinical and molecular characterization of hidradenitis suppurativa: a practical framework for novel therapeutic targets.
Moltrasio, Chiara; Tricarico, Paola Maura; Moura, Ronald; Brandao, Lucas André Cavalcanti; Crovella, Sergio; Marzano, Angelo Valerio... more authors ... less authors ( Karger Publishers , 2023 , Report)Background: The pathophysiological picture underlying hidradenitis suppurativa (HS) and its syndromic forms is still patchy, thus presenting a great challenge for dermatologists and researchers since just by better ... -
Different molecular pathways are disrupted in Pyoderma gangrenosum patients and are associated with the severity of the disease.
Moura, Ronald Rodrigues; Brandão, Lucas; Moltrasio, Chiara; Agrelli, Almerinda; Tricarico, Paola Maura; Maronese, Carlo Alberto; Crovella, Sergio; Marzano, Angelo Valerio... more authors ... less authors ( Nature Research , 2023 , Article)Pyoderma gangrenosum (PG) is a rare inflammatory skin disease classified within the spectrum of neutrophilic dermatoses. The pathophysiology of PG is yet incompletely understood but a prominent role of genetics facilitating ... -
Hidradenitis Suppurativa: A Perspective on Genetic Factors Involved in the Disease.
Moltrasio, Chiara; Tricarico, Paola Maura; Romagnuolo, Maurizio; Marzano, Angelo Valerio; Crovella, Sergio ( MDPI , 2022 , Article)Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease of the pilosebaceous unit, clinically consisting of painful nodules, abscesses, and sinus tracts mostly in, but not limited to, intertriginous skin areas. ... -
Holistic health record for Hidradenitis suppurativa patients.
Tricarico, Paola Maura; Moltrasio, Chiara; Gradišek, Anton; Marzano, Angelo V; Flacher, Vincent; Boufenghour, Wacym; von Stebut, Esther; Schmuth, Matthias; Jaschke, Wolfram; Gams, Matjaž; Boniotto, Michele; Crovella, Sergio... more authors ... less authors ( Nature Research , 2022 , Article)Hidradenitis suppurativa (HS) is a recurrent inflammatory skin disease with a complex etiopathogenesis whose treatment poses a challenge in the clinical practice. Here, we present a novel integrated pipeline produced by ... -
A loss-of-function NCSTN mutation associated with familial Dowling Degos disease and hidradenitis suppurativa
de Oliveira, Ana Sofia Lima Estevao; de Siqueira, Roberta Cardoso; Nait-Meddour, Cécile; Tricarico, Paola Maura; Moura, Ronald; Agrelli, Almerinda; d'Adamo, Adamo Pio; Jamain, Stéphane; Crovella, Sergio; de Fátima Medeiros Brito, Maria; Boniotto, Michele; Brandão, Lucas André Cavalcanti... more authors ... less authors ( Wiley , 2023 , Article)Dowling Degos disease (DDD) is a rare autosomal dominant genodermatosis characterized by acquired, slowly progressive reticulated pigmented lesions primarily involving flexural skin areas. Mutations in KRT5, POGLUT-1 and ... -
Paraviral cutaneous manifestations associated to SARS-CoV-2 Omicron variant
Zupin, Luisa; Moltrasio, Chiara; Tricarico, Paola Maura; Del Vecchio, Cecilia; Fontana, Francesco; Marzano, Angelo Valerio; Crovella, Sergio... more authors ... less authors ( Taylor and Francis Group , 2022 , Article)Background: The spreading of the SARS-CoV-2 Omicron variant is probably due to its increased transmissibility and ability to escape from neutralising antibodies. Cutaneous manifestations have been reported after infection ... -
A rare loss-of-function genetic mutation suggest a role of dermcidin deficiency in hidradenitis suppurativa pathogenesis
Tricarico, Paola Maura; Gratton, Rossella; Santos-Silva, Carlos André dos; Moura, Ronald Rodrigues de; Ura, Blendi; Sommella, Eduardo; Campiglia, Pietro; Del Vecchio, Cecilia; Moltrasio, Chiara; Berti, Irene; D’Adamo, Adamo Pio; Elsherbini, Ahmed M.A.; Staudenmaier, Lena; Chersi, Karin; Boniotto, Michele; Krismer, Bernhard; Schittek, Birgit; Crovella, Sergio... more authors ... less authors ( Frontiers Media , 2022 , Article)Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a multifactorial aetiology that involves a strict interplay between genetic factors, immune dysregulation and lifestyle. Familial forms represent ... -
Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling
de Oliveira, Ana Sofia Lima Estevao; Bloise, Giovanna; Moltrasio, Chiara; Coelho, Antonio; Agrelli, Almerinda; Moura, Ronald; Tricarico, Paola Maura; Jamain, Stéphane; Marzano, Angelo Valerio; Crovella, Sergio; Cavalcanti Brandão, Lucas André... more authors ... less authors ( MDPI , 2022 , Article)Hidradenitis suppurativa (HS) is an inflammatory skin condition clinically characterized by recurrent painful deep-seated nodules, abscesses, and sinus tracks in areas bearing apocrine glands, such as axillae, breasts, ... -
Variant Enrichment Analysis to Explore Pathways Functionality in Complex Autoinflammatory Skin Disorders through Whole Exome Sequencing Analysis.
Brandão, Lucas André Cavalcanti; Moura, Ronald Rodrigues de; Marzano, Angelo Valerio; Moltrasio, Chiara; Tricarico, Paola Maura; Crovella, Sergio... more authors ... less authors ( MDPI , 2022 , Article)The challenge of unravelling the molecular basis of multifactorial disorders nowadays cannot rely just on association studies searching for potential causative variants shared by groups of patients and not present in healthy ...