Browsing by Author "Kobeissy, Firas"
Now showing items 1-20 of 23
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2-Nucleobase-substituted 4,6-Diaminotriazine Analogs: Synthesis and Anti-cancer Activity in 5-Fluorouracil-Sensitive and Resistant Colorectal Cancer Cells.
( Bentham Science Publishers , 2022 , Article)Cancer continues to be the second leading cause of death worldwide with colorectal cancer (CRC) being the third most common type. Despite significant advances in cancer therapies, current treatment of CRC remains suboptimal. ... -
Advances in Cardiovascular Biomarker Discovery.
( MDPI , 2020 , Article Review)Cardiovascular diseases are the leading causes of mortality worldwide. Among them, hypertension and its pathological complications pose a major risk for the development of other cardiovascular diseases, including heart ... -
Assessing the psychological impact of Beirut Port blast: A cross-sectional study
( Lippincott, Williams & Wilkins , 2022 , Article)Beirut Port blast's magnitude is considered the third after Hiroshima and Nagasaki atomic bombings. This blast occurred in the densely populated section of Beirut, leaving more than six thousand injured patients. The ... -
The Brain And Exercise: In Sickness And In Health
( Frontiers Media , 2022 , Article)The brain, like any other organ in the body, is made up of various types of cells. Nerve cells called neurons are the major cells in the brain. Their main function is to transfer messages and orders to and from the organs ... -
Crosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms.
( Bentham Science Publishers , 2022 , Article Review)Microglia are the resident immune cells of the brain and play a crucial role in housekeeping and maintaining homeostasis of the brain microenvironment. Upon injury or disease, microglial cells become activated, at least ... -
Early metabolic impairment as a contributor to neurodegenerative disease: Mechanisms and potential pharmacological intervention
( Wiley , 2022 , Article Review)The metabolic syndrome comprises a family of clinical and laboratory findings, including insulin resistance, hyperglycemia, hypertriglyceridemia, low high-density lipoprotein cholesterol levels, and hypertension, in addition ... -
Epac as a tractable therapeutic target
( Elsevier , 2023 , Article)In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing ... -
Estrogen receptor and the gender bias in Raynaud's phenomenon.
( Bentham Science Publishers , 2023 , Other)Estrogen receptor and the gender bias in Raynaud's phenomenon. -
G protein estrogen receptor as a potential therapeutic target in Raynaud’s phenomenon
( Frontiers Media , 2022 , Article)Exaggerated cold-induced vasoconstriction can precipitate a pathogenesis called Raynaud’s phenomenon (RP). Interestingly, RP is significantly more prevalent in females than age-matched men, highlighting the potential ... -
High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury
( Elsevier , 2023 , Article)AimsTraumatic brain injury (TBI) constitutes a serious public health concern. Although TBI targets the brain, it can exert several systemic effects which can worsen the complications observed in TBI subjects. Currently, ... -
Inflammasomes as biomarkers and therapeutic targets in traumatic brain injury and related-neurodegenerative diseases: A comprehensive overview
( Elsevier , 2023 , Article)Given the ambiguity surrounding traumatic brain injury (TBI) pathophysiology and the lack of any Food and Drug Administration (FDA)-approved neurotherapeutic drugs, there is an increasing need to better understand the ... -
Inflammation and hypertension: Underlying mechanisms and emerging understandings
( wiley online library , 2023 , Article Review)Hypertension remains a major contributor to cardiovascular disease (CVD), a leading cause of global death. One of the major insults that drive increased blood pressure is inflammation. While it is the body's defensive ... -
Mitoquinone supplementation alleviates oxidative stress and pathologic outcomes following repetitive mild traumatic brain injury at a chronic time point
( Elsevier , 2022 , Article)Traumatic brain injury (TBI) is a major cause of disability and death. Mild TBI (mTBI) constitutes ~75% of all TBI cases. Repeated exposure to mTBI (rmTBI), leads to the exacerbation of the symptoms compared to single mTBI. ... -
Nano-Engineering in Traumatic Brain Injury
( Wiley , 2023 , Book chapter)Traumatic brain injury (TBI) is a leading cause of mortality and chronic disability worldwide TBI involves an initial primary phase triggered by an impactful force to the brain and a subsequent secondary pathological phase. ... -
Nanoparticles: Attractive tools to treat colorectal cancer
( Elsevier , 2022 , Article)Colorectal Cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Despite the notable advances achieved over the last few decades, CRC remains a hard-to-treat deadly disease in many patients. This ... -
Neurotrauma investigation through spatial omics guided by mass spectrometry imaging: Target identification and clinical applications
( Wiley , 2023 , Article Review)Traumatic brain injury (TBI) represents one of the major public health concerns worldwide due to the increase in TBI incidence as a result of injuries from daily life accidents such as sports and motor vehicle transportation ... -
Origanum syriacum L. Attenuates the Malignant Phenotype of MDA-MB231 Breast Cancer Cells
( Frontiers Media , 2022 , Article)Breast cancer is the leading cause of cancer-related deaths among women. Among breast cancer types, triple negative breast cancer (TNBC) is the most aggressive, and is resistant to hormonal and chemotherapeutic treatments. ... -
Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Alzheimer’s Disease?
( Springer Singapore , 2022 , Book chapter)Alzheimer’s disease (AD) is a debilitating neurodegenerative disease with devastating outcomes to patients and exhaustive burdens to healthcare systems. Alzheimer’s disease has always been the focus of extensive research ... -
Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Traumatic Brain Injury?
( Springer Singapore , 2022 , Book chapter)Traumatic brain injury (TBI) is one of the key causes of deaths and disabilities worldwide. TBI progresses in two phases. The primary phase of injury is the direct result of the physical damage caused by the external force ... -
SARS-CoV-2 involvement in central nervous system tissue damage
( Wolters Kluwer , 2022 , Article Review)As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread globally, it became evident that the SARS-CoV-2 virus infects multiple organs including the brain. Several clinical studies revealed ...
