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    Immunohistochemistry-Enabled Precision Medicine

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    Date
    2019-06-18
    Author
    Gatalica, Zoran
    Feldman, Rebecca
    Vranic, Semir
    Spetzler, David
    Metadata
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    Abstract
    Immunohistochemistry (IHC) can be applied to diagnostic aspects of pathologic examination to provide aid in assignment of lineage and histologic type of cancer. Increasingly, however, IHC is widely used to provide prognostic and predictive (theranostic) information about the neoplastic disease. A refinement of theranostic application of IHC can be seen in the use of “genomic probing” where antibody staining results are directly correlated with an underlying genetic alteration in the tumor (somatic mutations) and/or the patient (germline constitution). All these aspects of IHC find their best use in guiding the oncologists in the optimal use of therapy for the patients.
    DOI/handle
    http://dx.doi.org/10.1007/978-3-030-16391-4_4
    http://hdl.handle.net/10576/11704
    Collections
    • Medicine Research [‎1819‎ items ]

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