Show simple item record

AuthorAshour, Anas
AuthorAlhussain, Hashim
AuthorRashid, Umar Bin
AuthorAbughazzah, Labiba
AuthorGupta, Ishita
AuthorMalki, Ahmed
AuthorVranic, Semir
AuthorAl Moustafa, Ala-Eddin
Available date2020-06-01T05:20:33Z
Publication Date2020-05-27
Publication NameToxicsen_US
Identifierhttp://dx.doi.org/10.3390/toxics8020038
CitationAshour, A.; Alhussain, H.; Rashid, U.B.; Abughazzah, L.; Gupta, I.; Malki, A.; Vranic, S.; Al Moustafa, A.-E. E-Cigarette Liquid Provokes Significant Embryotoxicity and Inhibits Angiogenesis. Toxics 2020, 8, 38.
URIhttp://hdl.handle.net/10576/14988
AbstractE-cigarette smoking (ECS) is a new method of tobacco smoking that is gaining popularity as it is thought to be a "healthy method" of tobacco consumption. The adverse outcomes of ECS on the respiratory and cardiovascular systems in humans have been recently demonstrated. Nevertheless, the effect of e-cigarette liquid (ECL) on the early stage of embryogenesis and angiogenesis has not been explored yet. Chicken embryo at 3 days of incubation and its chorioallantoic membrane (CAM) of 5 days were used to explore the outcome of ECL on the embryo. Real-time PCR was also employed to study the regulation of a set of key controller genes of embryogenesis as well as angiogenesis. Our study revealed that ECL exposure is associated with a high rate of mortality in embryos as around 70% of treated embryos, at 3 days of incubation, die after 5 days of exposure. Additionally, ECL inhibits angiogenesis of the CAM of 5 days of incubation by more than 30%. These effects could be explained by the upregulation of , and as well as the downregulation of and genes, which are important key controller genes of embryogenesis as well as angiogenesis. Our data suggest clearly that ECS can have dramatic toxic outcomes on the early stage of embryogenesis as well as angiogenesis. Accordingly, we believe that further studies to assess the effects of ECS on human health are essential.
SponsorA-E-A.M’s lab is supported by grants from the Qatar University: QUHI-CMED-19/20-1, GCC # 2017- 002 QU/KU, and QUST-1-CMED-2020-2.
Languageen
PublisherMDPI
Subjectangiogenesis
Subjecte-cigarettes
Subjectembryo
Subjectgene deregulations
Subjecttoxicity
TitleE-Cigarette Liquid Provokes Significant Embryotoxicity and Inhibits Angiogenesis.
TypeArticle
Issue Number2
Volume Number8
ESSN2305-6304


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record