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المؤلفShurbaji, Samar
المؤلفAnlar, Gulsen G.
المؤلفHussein, Essraa A.
المؤلفElzatahry, Ahmed
المؤلفYalcin, Huseyin C.
تاريخ الإتاحة2020-08-09T05:25:47Z
تاريخ النشر2020-07-01
اسم المنشورCancers
المعرّفhttp://dx.doi.org/10.3390/cancers12071916
الاقتباسShurbaji, S.; G. Anlar, G.; A. Hussein, E.; Elzatahry, A.; C. Yalcin, H. Effect of Flow-Induced Shear Stress in Nanomaterial Uptake by Cells: Focus on Targeted Anti-Cancer Therapy. Cancers 2020, 12, 1916.
الرقم المعياري الدولي للكتاب2072-6694
معرّف المصادر الموحدhttp://hdl.handle.net/10576/15418
الملخص© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Recently, nanomedicines have gained a great deal of attention in diverse biomedical applications, including anti-cancer therapy. Being different from normal tissue, the biophysical microenvironment of tumor cells and cancer cell mechanics should be considered for the development of nanostructures as anti-cancer agents. Throughout the last decades, many efforts devoted to investigating the distinct cancer environment and understanding the interactions between tumor cells and have been applied bio-nanomaterials. This review highlights the microenvironment of cancer cells and how it is different from that of healthy tissue. We gave special emphasis to the physiological shear stresses existing in the cancerous surroundings, since these stresses have a profound effect on cancer cell/nanoparticle interaction. Finally, this study reviews relevant examples of investigations aimed at clarifying the cellular nanoparticle uptake behavior under both static and dynamic conditions.
اللغةen
الناشرMDPI
الموضوعAnti-cancer
Flow
In vitro
Nanomedicine
Nanoparticle
Shear stress
Targeted therapy
العنوانEffect of flow-induced shear stress in nanomaterial uptake by cells: Focus on targeted anti-cancer therapy
النوعArticle
رقم العدد7
رقم المجلد12
dc.accessType Open Access


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