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AuthorNisar, Sabah
AuthorHashem, Sheema
AuthorYadav, Santosh K
AuthorMuralitharan, Sankavi
AuthorTherachiyil, Lubna
AuthorSageena, Geetanjali
AuthorAl-Naemi, Hamda
AuthorHaris, Mohammad
AuthorBhat, Ajaz A
Available date2020-09-14T08:51:25Z
Publication Date2020
Publication NameCurrent Pharmaceutical Design
Identifierhttp://dx.doi.org/10.2174/1381612826666200115095937
CitationSabah Nisar , Sheema Hashem, Muzafar A. Macha , Santosh K. Yadav, Sankavi Muralitharan , Lubna Therachiyil, Geetanjali Sageena, Hamda Al-Naemi, Mohammad Haris and Ajaz A. Bhat*, “Exploring Dysregulated Signaling Pathways in Cancer”, Current Pharmaceutical Design (2020) 26: 429. https://doi.org/10.2174/1381612826666200115095937
ISSN1381-6128
URIhttp://hdl.handle.net/10576/16104
AbstractCancer cell biology takes advantage of identifying diverse cellular signaling pathways that are disrupted in cancer. Signaling pathways are an important means of communication from the exterior of cell to intracellular mediators, as well as intracellular interactions that govern diverse cellular processes. Oncogenic mutations or abnormal expression of signaling components disrupt the regulatory networks that govern cell function, thus enabling tumor cells to undergo dysregulated mitogenesis, to resist apoptosis, and to promote invasion to neighboring tissues. Unraveling of dysregulated signaling pathways may advance the understanding of tumor pathophysiology and lead to the improvement of targeted tumor therapy. In this review article, different signaling pathways and how their dysregulation contributes to the development of tumors have been discussed.
Languageen
PublisherBentham Science Publishers
SubjectAngiogenesis
apoptosis
cell invasion
cell proliferation
drug targets
metastasis
signaling pathways
tumor microenvironment.
TitleExploring Dysregulated Signaling Pathways in Cancer.
TypeArticle Review
Pagination429-445
Issue Number4
Volume Number26
ESSN1873-4286
dc.accessType Full Text


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