• A Novel Mutation (Q694X) in the ITGB3 Gene Causing Glanzmann’s Thrombasthenia from the Sultanate of Oman 

      Albalushi, Talal; AlZadjali, Shoaib; AlHaddabi, Hamood; Dennison, J. David; Alkindi, Salam; ... more authors ( The American Society of Hematology , 2008 , Article)
      Background: Glanzmann Thrombasthenia (GT) results from mutations in the genes ITGA2B and ITGB3, located on chromosome 17q21–23 which encodes the platelet glycoprotein αIIbβ3 complex, namely GPIIb (αIIb) and GPIIIa (β3), ...
    • Real-Time PCR Quantification of Metallothionein Gene Expression in Sprague–Dawley Rats Chronically Exposed to Cd 

      Al-Ghanem, M.; Al-Mahmoud, G.; Shanmugakonar, M.; Al-Naemi, H. ( American Association for Laboratory Animal Science , 2012 , Presentation)
      Toxicologic impact of Cd leads to multiple human pathologic conditions, and its effect on humans and animals has been extensively studied. Physiologic function of metallothionein (MT1) is not completely understood, but ...
    • NF-κB Essential MOdulator (NEMO) Is Critical for Thyroid Function 

      Reale, Carla; Iervolino, Anna; Scudiero, Ivan; Ferravante, Angela; Egildo D, Luca; ... more authors ( American Society for Biochemistry and Molecular Biology , 2016 , Article)
      The I-κB kinase (IKK) subunit NEMO/IKKγ (NEMO) is an adapter molecule that is critical for canonical activation of NF-κB, a pleiotropic transcription factor controlling immunity, differentiation, cell growth, tumorigenesis ...
    • Expression of active and inactive forms of CIK and CARMA 2sh proteins in Normal Human Epidermal Keratinocytes (NHEK) 

      Shanmugakonar, Muralitharan; Varadharajan, Kavitha; Vito, Pasquale (2016 , Poster)
      Psoriasis is a debilitating skin disease affecting approximately 23% of human population. The disease is considered to have key genetic underpinning and genome wide association studies and meta analysis have identified ...
    • The effect of acute ophiobolin A treatment on HO-mediated inflammatory processes 

      Posa, Aniko; Szabo, Renata; Szalai, Zita; Kupai, Krisztina; Deim, Zoltan; ... more authors ( SAGE Publications Ltd , 2017 , Article)
      Many microbial and plant-derived metabolites contribute to the production of inflammatory mediators and the expression of pro-inflammatory molecules. Ophiobolin A (OPA) is a fungal secondary metabolite produced by Bipolaris ...
    • CARMA2sh and ULK2 control pathogen-associated molecular patterns recognition in human keratinocytes: psoriasis-linked CARMA2sh mutants escape ULK2 censorship 

      Scudiero, Ivan; Mazzone, Pellegrino; D'Andrea, Luca E.; Ferravante, Angela; Zotti, Tiziana; ... more authors ( Nature , 2017 , Article)
      The molecular complexes formed by specific members of the family of CARMA proteins, the CARD domain-containing adapter molecule BCL10 and MALT1 (CBM complex) represent a central hub in regulating activation of the pleiotropic ...
    • Humane care and use of laboratory animals training program (HCULA) 

      Al-Naemi, Hamda; Zabady, Hadeer (2017 , Poster)
      HCULA is the first basic training program that covers the use of Rodents as animals models in biomedical research, it is composed of theory and hands on training courses . The theory course is required to all students ...
    • Biosecurity And Biosafety In LARC 

      Govindharajan, Vijay Kanth; Tesfaldet, Kahsu; Tesfom, Sielu; Joseph, Benny; Al Naemi, Hamda (2017 , Poster)
      * LARC is Specific Pathogen Free(SPF) facility * LARC is free of Specific list of Pathogens maintained by routine testing. * Bio security & Bio safety are main components to maintain the LARC facility
    • Animal Husbandry And Care 

      Govindharajan, Vijay Kanth; Kahsu, Tesfaldet; Sielu, Tesfom; Al Naemi, Hamda (2017 , Poster)
      * Qatar University – Laboratory Animal Research Centre (LARC) is providing highest quality animal husbandry and care * LARC is Specific pathogen Free (SPF) facility with state of the art animal housing & supporting ...
    • Diagnostic Microbiology Laboratory Monitoring of LARC 

      Khan, Imran; Shanmugakonar, Muralitharan; Aboujassoum, Hamda; Al Naemi, Hamda (2017 , Poster)
      Microbial free environment of a research facility is critical to maintain animal health. Establishing Microbiological Monitoring Program is mandatory to assure the quality of the system. Microbiological monitoring involves ...
    • Animal Health Monitoring Program (AHMP) of LARC 

      Shanmugakonar, Muralitharan; Abujassoum, Hamda; Khan, Imran; Al Naemi, Hamda (2017 , Poster)
      Animal health monitoring is important to maintain the health of the animals used for research purpose. Maintaining healthy research animals is the prime requisite for best research outcomes. Health monitoring is performed ...
    • Effect of CARMA 2sh gene in Mouse embryonic stem (ES) cells 

      Shanmugakonar, Muralitharan; Varadharajan, Kavitha; Vito, Pasquale (2017 , Poster)
      CARMA2 belongs to the CARMA family of proteins. They are involved in the regulation and activation of NF-κB that have a central role in the control of immune and inflammatory response, and cell survival and proliferation. ...
    • ANIMAL MODEL FOR CHILDHOOD OBESITY 

      Al-Naemi, Hamda; Das, Sandra Concepcion (2017 , Poster)
      Obesity has been recognized as a global health problem and linked with chronic diseases such as diabetes mellitus, cardiovascular syndromes, musculoskeletal disorders and some cancers. Children exposed to high carbohydrate, ...
    • Environmental Health Monitoring Program (EHMP) of LARC 

      Shanmugakonar, Muralitharan; Abujassoum, Hamda; Khan, Imran; Al Naemi, Hamda (2017 , Poster)
      Routine environmental monitoring is the prime necessity to maintain a Specific Pathogen Free (SPF) facility. Monitoring the animals & its environment is important to control the contamination and outbreak of disease. ...
    • ENDOTHELIAL NITRIC OXIDE ACTIVITY & BIOAVAILABILITY DURING OBESITY CONDITIONS 

      Das, Sandra Concepcion; Al-Naemi, Hamda (2017 , Poster)
      Obesity has been recognized as a pandemic and linked with several metabolic dysfunctions. One of the hallmarks in the onset of obesity is the development of hypertension coupled with endothelial dysfunction. (ED) A fundamental ...
    • SIRT1 may play a crucial role in overload-induced hypertrophy of skeletal muscle 

      Koltai, Erika; Bori, Zoltán; Chabert, Clovis; Dubouchaud, Hervé; Naito, Hisashi; ... more authors ( Wiley , 2017 , Article)
      Silent mating type information regulation 2 homologue 1 (SIRT1) activity and content increased significantly in overload-induced hypertrophy. SIRT1-mediated signalling through Akt, the endothelial nitric oxide synthase ...
    • The physiological effects of concurrent strength and endurance training sequence: A systematic review and meta-analysis. 

      Murlasits, Zsolt; Kneffel, Zsuzsanna; Thalib, Lukman ( Taylor & Francis , 2017 , Article Review)
      We conducted a systematic literature review and meta-analysis to assess the chronic effects of the sequence of concurrent strength and endurance training on selected important physiological and performance parameters, ...
    • In Vitro Analysis of Psoriasis Linked CARMA2sh Gene in Keratinocytes and Mouse Embryonic Stem Cells towards Developing a Murine Transgenic Model 

      Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Vito, Pasquale ( American Association For Laboratory Animal Science , 2017 , Poster)
      Psoriasis is a debilitating skin disease affecting approximately 23% of human population. Genome-wide association studies have identified more than 40 susceptibility loci for psoriasis. CARMA2 proteins play a major role ...
    • Gut Microbiota Dysbiosis in Cafeteria Diet Fed Sprague Dawley Rats 

      Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Das, Sandra Concepcion; Al-Naemi, Hamda A. ( Scientific Research Publishing , 2018 , Article)
      Diet plays a major role in the body physiology and metabolism. The quantity, nature and stability of the macronutrients present in the diet have a major impact on the composition of gut microbiota. Gut microbiota plays a ...
    • Changes in resting-state functional brain activity are associated with waning cognitive functions in HIV-infected children. 

      Yadav, Santosh K; Gupta, Rakesh K; Hashem, Sheema; Bhat, Ajaz A; Garg, Ravindra K; ... more authors ( Elsevier , 2018 , Article)
      Delayed brain development in perinatally HIV-infected children may affect the functional brain activity and subsequently cognitive function. The current study evaluated the functional brain activity in HIV-infected children ...