عرض بسيط للتسجيلة

المؤلفRich, Laurie J
المؤلفBagga, Puneet
المؤلفWilson, Neil E
المؤلفSchnall, Mitchell D
المؤلفDetre, John A
المؤلفHaris, Mohammad
المؤلفReddy, Ravinder
تاريخ الإتاحة2020-09-14T10:56:22Z
تاريخ النشر2020
اسم المنشورNature Biomedical Engineering
المعرّفhttp://dx.doi.org/10.1038/s41551-019-0499-8
الاقتباسRich, L.J., Bagga, P., Wilson, N.E. et al. 1H magnetic resonance spectroscopy of 2H-to-1H exchange quantifies the dynamics of cellular metabolism in vivo. Nat Biomed Eng 4, 335–342 (2020). https://doi.org/10.1038/s41551-019-0499-8
الرقم المعياري الدولي للكتاب2157-846X
معرّف المصادر الموحدhttp://hdl.handle.net/10576/16111
الملخصQuantitative mapping of the in vivo dynamics of cellular metabolism via non-invasive imaging contributes to our understanding of the initiation and progression of diseases associated with dysregulated metabolic processes. Current methods for imaging cellular metabolism are limited by low sensitivities, costs or the use of specialized hardware. Here, we introduce a method that captures the turnover of cellular metabolites by quantifying signal reductions in proton magnetic resonance spectroscopy (MRS) resulting from the replacement of H with H. The method, which we termed quantitative exchanged-label turnover MRS, only requires deuterium-labelled glucose and standard magnetic resonance imaging scanners, and with a single acquisition provides steady-state information and metabolic rates for several metabolites. We used the method to monitor glutamate, glutamine, γ-aminobutyric acid and lactate in the brains of unaffected and glioma-bearing rats following the administration of H-labelled glucose and H-labelled acetate. Quantitative exchanged-label turnover MRS should broaden the applications of routine H MRS.
اللغةen
الناشرNature Research
الموضوعCancer imaging
Cancer metabolism
Magnetic resonance imaging
Neuroscience
Translational research
العنوان1H magnetic resonance spectroscopy of 2H-to-1H exchange quantifies the dynamics of cellular metabolism in vivo
النوعArticle
الصفحات335–342
رقم المجلد4
dc.accessType Abstract Only


الملفات في هذه التسجيلة

الملفاتالحجمالصيغةالعرض

لا توجد ملفات لها صلة بهذه التسجيلة.

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة