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AuthorGupta, Ishita
AuthorRizeq, Balsam
AuthorVranic, Semir
AuthorMoustafa, Ala-Eddin Al
AuthorAl Farsi, Halema
Available date2020-09-21T04:56:30Z
Publication Date2020-09-15
Publication NameInternational Journal of Molecular Sciencesen_US
Identifierhttp://dx.doi.org/10.3390/ijms21186750
CitationGupta, I.; Rizeq, B.; Vranic, S.; Moustafa, A.-E.A.; Al Farsi, H. Circulating miRNAs in HER2-Positive and Triple Negative Breast Cancers: Potential Biomarkers and Therapeutic Targets. Int. J. Mol. Sci. 2020, 21, 6750.
ISSN1661-6596
URIhttp://hdl.handle.net/10576/16205
AbstractBreast cancer is one of the most prevalent diseases among women worldwide and is highly associated with cancer-related mortality. Of the four major molecular subtypes, HER2-positive and triple-negative breast cancer (TNBC) comprise more than 30% of all breast cancers. While the HER2-positive subtype lacks estrogen and progesterone receptors and overexpresses HER2, the TNBC subtype lacks estrogen, progesterone and HER2 receptors. Although advances in molecular biology and genetics have substantially ameliorated breast cancer disease management, targeted therapies for the treatment of estrogen-receptor negative breast cancer patients are still restricted, particularly for TNBC. On the other hand, it has been demonstrated that microRNAs, miRNAs or small non-coding RNAs that regulate gene expression are involved in diverse biological processes, including carcinogenesis. Moreover, circulating miRNAs in serum/plasma are among the most promising diagnostic/therapeutic tools as they are stable and relatively easy to quantify. Various circulating miRNAs have been identified in several human cancers including specific breast cancer subtypes. This review aims to discuss the role of circulating miRNAs as potential diagnostic and prognostic biomarkers as well as therapeutic targets for estrogen-receptor negative breast cancers, HER2+ and triple negative.
Languageen
PublisherMDPI
SubjectHER2-positive
Subjectbiomarkers
Subjectbreast cancer
Subjectcirculating miRNAs
Subjectreceptor negative breast cancer
Subjecttriple negative breast cancer
TitleCirculating miRNAs in HER2-Positive and Triple Negative Breast Cancers: Potential Biomarkers and Therapeutic Targets.
TypeArticle
Issue Number18
Volume Number21
ESSN1422-0067


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