Formulation and antioxidant properties of curcumin gum Arabic nanoparticles for delivery to cancer cells
التاريخ
2020-12-22المؤلف
Hassani, AHussain, S A
Enezei, H H
Saeed, S
Ibrahim, W N
Al-Qubaisi, M S
Zentou, H
Rosli, R
Doolaanea, A A
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البيانات الوصفية
عرض كامل للتسجيلةالملخص
Curcumin nanoparticles (Cur/GANPs) were formulated based on gum arabic (GA) as a stabilizer coatings for nanoparticles through efficient synthesis approach. The current study investigated the antioxidant properties and antihypertensive activity of curcumin (Cur) using various established in vitro assays, such as 1,1-diphenyl-2-picrylhydrazyl (DPPH) as well as angiotensin converting enzyme (ACE) inhibitory activity. The in vitro cytotoxicity of Cur/GANPs against human liver cancer (HepG2), and colon cancer (HT29) was investigated. The exposure of human cancer cells to Cur/GANPs (1.56-100 µg/ml) using MTT (3-(4,5-dimethylthiazol-2-yl) 2,5-diphenyl tetrazolium bromide) has revealed that the Cur/GANPs inhibited the growth of cell lines examined in a dose dependent manner. Hence, Cur/GANPs nanoparticles may have great potential to be applied for cancer treatment.
المجموعات
- العلوم الحيوية الطبية [711 items ]