Race/ethnicity and challenges for optimal insulin therapy
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التاريخ
2021-05-31المؤلف
Nayla Cristina, do Vale MoreiraCeriello, Antonio
Basit, Abdul
Balde, Naby
Mohan, V.
Gupta, Ritesh
Misra, Anoop
Bhowmik, Bishwajit
Lee, Moon K.
Zuo, Hui
Shi, Zumin
Wang, Youfa
Montenegro, Renan M.
Fernandes, Virgínia Oliveira
Colagiuri, Stephen
Boulton, Andrew J.M.
Hussain, Akhtar
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البيانات الوصفية
عرض كامل للتسجيلةالملخص
AimsWe aimed to review insulin dosing recommendations, insulin regulation and its determinants, glycaemic response to carbohydrates, and the efficacy and safety of insulin therapy in different races/ethnicities. MethodsWe searched for articles in PubMed and Google Scholar databases up to 31 March 2021, with the following keywords: “ethnicity”, “diabetes”, “insulin”, “history of insulin”, “insulin therapy”, “food/rice”, “carbohydrate intake”, “insulin resistance”, “BMI”, “insulin dosing”, “insulin sensitivity”, “insulin response”, “glycaemic index”, “glycaemic response”, “efficacy and safety”, with interposition of the Boolean operator “AND”.In addition, we reviewed the reference lists of the articles found. ResultsThe differential effect of race/ethnicity has not yet been considered in current insulin therapy guidelines. Nevertheless, body size and composition, body mass index, fat distribution, diet, storage, and energy expenditure vary significantly across populations. Further, insulin sensitivity, insulin response, and glycaemicresponse to carbohydrates differ by ethnicity. These disparities may lead to different insulin requirements, adversely impacting the efficacy and safety of insulin therapy among ethnic groups. ConclusionsRace/ethnicity affects glucose metabolism and insulin regulation.Until now, international guidelines addressing racial/ethnic-specific clinical recommendations are limited. Comprehensive updated insulin therapy guidelines by ethnicity are urgently needed.
معرّف المصادر الموحد
https://www.sciencedirect.com/science/article/pii/S0168822721001820المجموعات
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