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AuthorKheraldine, Hadeel
AuthorRachid, Ousama
AuthorM Habib, Abdella
AuthorAl Moustafa, Ala-Eddin
AuthorF. Benter, Ibrahim
Available date2021-10-25T07:32:37Z
Publication Date2021-08
Publication NameAdvanced Drug Delivery Reviews
Identifierhttp://dx.doi.org/10.1016/j.addr.2021.113908
CitationKheraldine, Hadeel, et al. “Emerging Innate Biological Properties of Nano-Drug Delivery Systems: A Focus on Pamam Dendrimers and Their Clinical Potential.” Advanced Drug Delivery Reviews, 2021, p. 113908., https://doi.org/10.1016/j.addr.2021.113908.
ISSN0169-409X
URIhttp://hdl.handle.net/10576/24672
AbstractDrug delivery systems or vectors are usually needed to improve the bioavailability and effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an organ, tissue or cellular level. However, emerging technologies with sensitive readouts as well as a greater understanding of physiological/biological systems have revealed that polymeric drug delivery systems are not biologically inert but can have innate or intrinsic biological actions. In this article, we review the emerging multiple innate biological/toxicological properties of naked polyamidoamine (PAMAM) dendrimer delivery systems in the absence of any drug cargo and discuss their correlation with the defined physicochemical properties of PAMAMs in terms of molecular size (generation), architecture, surface charge and chemistry. Further, we assess whether any of the reported intrinsic biological actions of PAMAMs such as their antimicrobial activity or their ability to sequester glucose and modulate key protein interactions or cell signaling pathways, can be exploited clinically such as in the treatment of diabetes and its complications.
Languageen
PublisherElsevier
SubjectPAMAM
Dendrimer
Drug delivery system
Biological properties
Toxicity
Nanotoxicology
Diabetes
Antimicrobial
TitleEmerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential
TypeArticle
Volume Number178
dc.accessType Open Access


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