DNA Damage/Repair Management in Cancers
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DNA damage can alter nucleotide sequences and lead to expression of dysfunctional proteins that impact normal cellular physiology. Sources of DNA damage can be endogenous or exogenous and include reactive oxygen species (ROS) or ionizing radiation. DNA damaging agents can broadly be classified into two different categories: clastogens and aneugens. Clastogens cause chromosomal breaks and induce micronuclei (MN) due to generation of acentric chromosomal fragments. In contrast, aneugens lead to the incorporation of whole chromosomes in MN by generation of aneuploidy that affects cell proliferation and the mitotic spindle apparatus
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Zhao, X.; Nakagawa, T.; Zuo, M.J. ( Institute of Electrical and Electronics Engineers Inc. , 2014 , Article)This paper proposes age and periodic replacement last models with continuous, and discrete policies. That is, an operating unit is replaced preventively at time T of operation as a strategic policy, or at a number N of ...
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