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    DNA Damage/Repair Management in Cancers

    Thumbnail
    Date
    2021-12-23
    Author
    Alhmoud, Jehad F.
    Woolley, John F.
    Al Moustafa, Ala-Eddin
    Malki, Mohammed Imad
    Metadata
    Show full item record
    Abstract
    DNA damage can alter nucleotide sequences and lead to expression of dysfunctional proteins that impact normal cellular physiology. Sources of DNA damage can be endogenous or exogenous and include reactive oxygen species (ROS) or ionizing radiation. DNA damaging agents can broadly be classified into two different categories: clastogens and aneugens. Clastogens cause chromosomal breaks and induce micronuclei (MN) due to generation of acentric chromosomal fragments. In contrast, aneugens lead to the incorporation of whole chromosomes in MN by generation of aneuploidy that affects cell proliferation and the mitotic spindle apparatus
    URI
    https://www.routledge.com/Advances-in-Medical-Biochemistry-Genomics-Physiology-and-Pathology/Bawa-Chang-Audette-Diwan-Faiz/p/book/9789814877442#
    DOI/handle
    http://hdl.handle.net/10576/25103
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    • Medicine Research [‎687‎ items ]

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