DNA Damage/Repair Management in Cancers
| Author | Alhmoud, Jehad F. |
| Author | Woolley, John F. |
| Author | Al Moustafa, Ala-Eddin |
| Author | Malki, Mohammed Imad |
| Available date | 2021-11-24T09:40:06Z |
| Publication Date | 2021-12-23 |
| Publication Name | Advances in Medical Biochemistry, Genomics, Physiology, and Pathology |
| Citation | Alhmoud, Jehad F. , Woolley, John F. , Al Moustafa, Ala-Eddin & Malki, Mohammed Imad (2021). DNA Damage/Repair Management in Cancers. Advances in Medical Biochemistry, Genomics, Physiology, and Pathology. 309 - 339. UK: Routledge. |
| ISBN | 9789814877442 |
| Abstract | DNA damage can alter nucleotide sequences and lead to expression of dysfunctional proteins that impact normal cellular physiology. Sources of DNA damage can be endogenous or exogenous and include reactive oxygen species (ROS) or ionizing radiation. DNA damaging agents can broadly be classified into two different categories: clastogens and aneugens. Clastogens cause chromosomal breaks and induce micronuclei (MN) due to generation of acentric chromosomal fragments. In contrast, aneugens lead to the incorporation of whole chromosomes in MN by generation of aneuploidy that affects cell proliferation and the mitotic spindle apparatus |
| Sponsor | Funding: Research of Dr. Malki’s Lab has been supported by grants from Qatar University: QUCG-CMED-20/21-3, QUST-1-CMED-2019-23 and QUST-1-CMED-2020-13 Acknowledgments: We are thankful to Nagesh Kalakonda and Shifa Rostom for their critical reading of the chapter. The publication of this chapter was funded by the Qatar National Library. |
| Language | en |
| Publisher | Routledge |
| Relation | http://hdl.handle.net/10576/14494 |
| Subject | DNA damage DNA repair pathway DNA lesion reactive oxygen species clastogens aneugens genomic instability DNA damaging agents micronuclei nucleoplasmic bridges nuclear buds misrepaired DNA single strand breaks double strand breaks ionizing irradiation apoptosis programmed cell death ataxia telangiectasia RAD3-related base excision repair nucleotide excision repair non-homologous end joining homologous recombination DNA mismatch repair cyclin-dependent kinase Xeroderma pigmentosum trichothiodystrophy microsatellite instability cell cycle biomarkers |
| Type | Book chapter |
| Pagination | 309 - 339 |
| Volume Number | 1 |
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