Proteomic study identifies glycolytic and inflammation pathways involved in recurrent otitis media
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Date
2020-12-01Author
Ura, BlendiCelsi, Fulvio
Zupin, Luisa
Arrigoni, Giorgio
Battisti, Ilaria
Gaita, Bartolomea
Grasso, Domenico Leonardo
Orzan, Eva
Sagredini, Raffaella
Barbi, Egidio
Crovella, Sergio
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Recurrent acute otitis media (RAOM) in children is clinically defined as the occurrence of at least three episodes of acute otitis media over a course of 6 months. A further common pathological condition of interest in the context of pediatric otolaryngology is adenotonsillar hypertrophy (ATH), a common cause of obstructive sleep apnea syndrome. Aimed at unraveling the differential modulation of proteins in the two pathologies and at understanding the possible pathways involved in their onset, we analyzed the proteomic profile of the adenoids from 14 RAOM and ATH patients by using two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS). The 2-DE coupled with MS allowed us to identify 23 spots with significant (p-value < 0.05) changes in protein amount, recognizing proteins involved in neutrophil degranulation and glycolysis pathways.
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