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AuthorSara, Amjad
AuthorNisar, Sabah
AuthorBhat, Ajaz A.
AuthorShah, Ab Rauf
AuthorFrenneaux, Michael P.
AuthorFakhro, Khalid
AuthorHaris, Mohammad
AuthorReddy, Ravinder
AuthorPatay, Zoltan
AuthorBaur, Joseph
AuthorBagga, Puneet
Available date2022-02-27T05:24:38Z
Publication Date2021-07-31
Publication NameMolecular Metabolism
Identifierhttp://dx.doi.org/10.1016/j.molmet.2021.101195
CitationAmjad, Sara؛ Nisar, Sabah؛ Bhat, Ajaz A.؛ Shah, Ab Rauf؛ Frenneaux, Michael P.؛ Fakhro, Khalid؛ Haris, Mohammad؛ Reddy, Ravinder؛ Patay, Zoltan؛ Baur, Joseph؛ Bagga, Puneet (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular Metabolism, 49, 101195.
ISSN22128778
URIhttps://www.sciencedirect.com/science/article/pii/S2212877821000351
URIhttp://hdl.handle.net/10576/27406
AbstractBackgroundNicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in every living cell, is involved in a myriad of metabolic processes associated with cellular bioenergetics. For this reason, NAD+ is often studied in the context of aging, cancer, and neurodegenerative and metabolic disorders. Scope of reviewCellular NAD+ depletion is associated with compromised adaptive cellular stress responses, impaired neuronal plasticity, impaired DNA repair, and cellular senescence. Increasing evidence has shown the efficacy of boosting NAD+ levels using NAD+ precursors in various diseases. This review provides a comprehensive understanding into the role of NAD+ in aging and other pathologies and discusses potential therapeutic targets. Major conclusionsAn alteration in the NAD+/NADH ratio or the NAD+ pool size can lead to derailment of the biological system and contribute to various neurodegenerative disorders, aging, and tumorigenesis. Due to the varied distribution of NAD+/NADH in different locations within cells, the direct role of impaired NAD+-dependent processes in humans remains unestablished. In this regard, longitudinal studies are needed to quantify NAD+ and its related metabolites. Future research should focus on measuring the fluxes through pathways associated with NAD+ synthesis and degradation.
Languageen
PublisherElsevier
SubjectNAD+
Aging
Cancer
Metabolism
Neurodegeneration
Sirtuins
TitleRole of NAD+ in regulating cellular and metabolic signaling pathways
TypeArticle Review
Volume Number49
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Open Access


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