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المؤلفBhat, A.A.
المؤلفBhat, Ajaz A.
المؤلفNisar, Sabah
المؤلفMaacha, Selma
المؤلفCarneiro-Lobo, Tatiana Correa
المؤلفAkhtar, Sabah
المؤلفSiveen, Kodappully Sivaraman
المؤلفWani, Nissar A.
المؤلفRizwan, Arshi
المؤلفBagga, Puneet
المؤلفSingh, Mayank
المؤلفReddy, Ravinder
المؤلفUddin, Shahab
المؤلفGrivel, Jean Charles
المؤلفChand, Gyan
المؤلفFrenneaux, Michael P.
المؤلفSiddiqi, Mushtaq A.
المؤلفBedognetti, Davide
المؤلفEl-Rifai, Wael
المؤلفMacha, Muzafar A.
المؤلفHaris, Mohammad
تاريخ الإتاحة2022-02-27T07:49:21Z
تاريخ النشر2021-12-01
اسم المنشورMolecular Cancer
المعرّفhttp://dx.doi.org/10.1186/s12943-020-01294-3
الاقتباسBhat, A.A., Nisar, S., Maacha, S. et al. Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy. Mol Cancer 20, 2 (2021). https://doi.org/10.1186/s12943-020-01294-3
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85098541807&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/27436
الملخصEsophageal cancer (EC) is a disease often marked by aggressive growth and poor prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant metastases among patients with advanced disease account for the high mortality rate. The tumor microenvironment (TME) contains several cell types, including fibroblasts, immune cells, adipocytes, stromal proteins, and growth factors, which play a significant role in supporting the growth and aggressive behavior of cancer cells. The complex and dynamic interactions of the secreted cytokines, chemokines, growth factors, and their receptors mediate chronic inflammation and immunosuppressive TME favoring tumor progression, metastasis, and decreased response to therapy. The molecular changes in the TME are used as biological markers for diagnosis, prognosis, and response to treatment in patients. This review highlighted the novel insights into the understanding and functional impact of deregulated cytokines and chemokines in imparting aggressive EC, stressing the nature and therapeutic consequences of the cytokine-chemokine network. We also discuss cytokine-chemokine oncogenic potential by contributing to the Epithelial-Mesenchymal Transition (EMT), angiogenesis, immunosuppression, metastatic niche, and therapeutic resistance development. In addition, it discusses the wide range of changes and intracellular signaling pathways that occur in the TME. Overall, this is a relatively unexplored field that could provide crucial insights into tumor immunology and encourage the effective application of modulatory cytokine-chemokine therapy to EC.
راعي المشروعThis study was supported by a PI grant from Sidra Medicine (5071012001) to Mohammad Haris. Ajaz A. Bhat is supported by Sidra Medicine internal grant (5011041002) and Ramalinga swami (Grant number: D.O.NO.BT/HRD/35/02/2006) Fellowship to Muzafar A. Macha and Nissar A. Wani by Department of Biotechnology (DBT), Govt. of India, New Delhi. Shahab Uddin is supported by Medical Research Centre grants (grant# 16102/6, #16354/16).
اللغةen
الناشرBMC
الموضوعChemokines
Cytokines
Drug targets
Epithelial-Mesenchymal transition
Esophageal cancer
Immune evasion
Inflammation
Tumor microenvironment
العنوانCytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy
النوعArticle Review
رقم العدد1
رقم المجلد20
ESSN1476-4598
dc.accessType Open Access


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