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AuthorBhat, A.A.
AuthorBhat, Ajaz A.
AuthorNisar, Sabah
AuthorMaacha, Selma
AuthorCarneiro-Lobo, Tatiana Correa
AuthorAkhtar, Sabah
AuthorSiveen, Kodappully Sivaraman
AuthorWani, Nissar A.
AuthorRizwan, Arshi
AuthorBagga, Puneet
AuthorSingh, Mayank
AuthorReddy, Ravinder
AuthorUddin, Shahab
AuthorGrivel, Jean Charles
AuthorChand, Gyan
AuthorFrenneaux, Michael P.
AuthorSiddiqi, Mushtaq A.
AuthorBedognetti, Davide
AuthorEl-Rifai, Wael
AuthorMacha, Muzafar A.
AuthorHaris, Mohammad
Available date2022-02-27T07:49:21Z
Publication Date2021-12-01
Publication NameMolecular Cancer
Identifierhttp://dx.doi.org/10.1186/s12943-020-01294-3
CitationBhat, A.A., Nisar, S., Maacha, S. et al. Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy. Mol Cancer 20, 2 (2021). https://doi.org/10.1186/s12943-020-01294-3
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85098541807&origin=inward
URIhttp://hdl.handle.net/10576/27436
AbstractEsophageal cancer (EC) is a disease often marked by aggressive growth and poor prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant metastases among patients with advanced disease account for the high mortality rate. The tumor microenvironment (TME) contains several cell types, including fibroblasts, immune cells, adipocytes, stromal proteins, and growth factors, which play a significant role in supporting the growth and aggressive behavior of cancer cells. The complex and dynamic interactions of the secreted cytokines, chemokines, growth factors, and their receptors mediate chronic inflammation and immunosuppressive TME favoring tumor progression, metastasis, and decreased response to therapy. The molecular changes in the TME are used as biological markers for diagnosis, prognosis, and response to treatment in patients. This review highlighted the novel insights into the understanding and functional impact of deregulated cytokines and chemokines in imparting aggressive EC, stressing the nature and therapeutic consequences of the cytokine-chemokine network. We also discuss cytokine-chemokine oncogenic potential by contributing to the Epithelial-Mesenchymal Transition (EMT), angiogenesis, immunosuppression, metastatic niche, and therapeutic resistance development. In addition, it discusses the wide range of changes and intracellular signaling pathways that occur in the TME. Overall, this is a relatively unexplored field that could provide crucial insights into tumor immunology and encourage the effective application of modulatory cytokine-chemokine therapy to EC.
SponsorThis study was supported by a PI grant from Sidra Medicine (5071012001) to Mohammad Haris. Ajaz A. Bhat is supported by Sidra Medicine internal grant (5011041002) and Ramalinga swami (Grant number: D.O.NO.BT/HRD/35/02/2006) Fellowship to Muzafar A. Macha and Nissar A. Wani by Department of Biotechnology (DBT), Govt. of India, New Delhi. Shahab Uddin is supported by Medical Research Centre grants (grant# 16102/6, #16354/16).
Languageen
PublisherBMC
SubjectChemokines
Cytokines
Drug targets
Epithelial-Mesenchymal transition
Esophageal cancer
Immune evasion
Inflammation
Tumor microenvironment
TitleCytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy
TypeArticle Review
Issue Number1
Volume Number20
ESSN1476-4598
dc.accessType Open Access


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