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AuthorDana E., Al-Ansari
AuthorAl-Badr, Mashael
AuthorZakaria, Zain Z.
AuthorMohamed, Nura Adam
AuthorNasrallah, Gheyath K.
AuthorYalcin, Huseyin C.
AuthorAbou-Saleh, Haissam
Available date2022-04-24T08:18:42Z
Publication Date2022-04-20
Publication NameToxicology Reports
Identifierhttp://dx.doi.org/10.1016/j.toxrep.2022.04.016
CitationDana E. Al-Ansari, Mashael Al-Badr, Zain Z. Zakaria, Nura Adam Mohamed, Gheyath K. Nasrallah, Huseyin C. Yalcin and Haissam Abou-Saleh, Evaluation of Metal-Organic Framework MIL-89 Nanoparticles Toxicity on Embryonic Zebrafish Development, Toxicology Reports, (2022) doi:https://doi.org/10.1016/j.toxrep.2022.04.016
ISSN2214-7500
URIhttps://www.sciencedirect.com/science/article/pii/S2214750022000993?v=s5
URIhttp://hdl.handle.net/10576/30246
AbstractMetal-Organic Framework MIL-89 nanoparticles garnered remarkable attention for their widespread use in technological applications. However, the impact of these nanomaterials on human and environmental health is still limited, and concerns regarding the potential risk of exposure during manipulation is constantly rising. Therefore, the extensive use of nanomaterials in the medical field necessitates a comprehensive assessment of their safety and interaction with different tissues of the body system. In this study, we evaluated the systemic toxicity of nanoMIL-89 using Zebrafish embryos as a model system to determine the acute developmental effect. Zebrafish embryos were exposed to a range of nanoMIL-89 concentrations (1 – 300µM) at 4hours post-fertilization (hpf) for up to 120 hpf. The viability and hatching rate were evaluated at 24 - 72 hpf, whereas the cardiac function was assessed at 72 and 96 hpf, and the neurodevelopment and hepatic steatosis at 120 hpf. Our study shows that nanoMIL-89 exerted no developmental toxicity on zebrafish embryos at low concentrations (1–10µM). However, the hatching time and heart development were affected at high concentrations of nanoMIL-89 (> 30µM). Our findings add novel information into the available data about the in vivo toxicity of nanoMIL-89 and demonstrate its innocuity and safe use in biological, environmental, and medical applications.
SponsorThis work was funded by Qatar National Research Fund (QNRF) through Undergraduate Research Experience Program (UREP22-140-3-023), High School Research Experience Program (HSREP1-0422-190053) for HAS, and National Priority Research Program (NPRP 10-0123-170222) for HCY. Also, we would like to thank the Pickford Award, from the British Pharmacological Society, received by NAM, for their generous contribution that aided the preparation of the nanoparticles used in this study. The graphical abstract was created with BioRender.com.
Languageen
PublisherElsevier
SubjectDanio rerio
Larvae
Development
Organ toxicity
Nanotechnology
TitleEvaluation of Metal-Organic Framework MIL-89 Nanoparticles Toxicity on Embryonic Zebrafish Development
TypeArticle
Open Access user License http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.accessType Open Access


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