Browsing Medicine Research by Publisher "Nature Research"
Now showing items 1-14 of 14
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Abnormal corneal nerve morphology and brain volume in patients with schizophrenia
( Nature Research , 2022 , Article)Neurodevelopmental and neurodegenerative pathology occur in Schizophrenia. This study compared the utility of corneal confocal microscopy (CCM), an ophthalmic imaging technique with MRI brain volumetry in quantifying ... -
COVID-19 engages clinical markers for the management of cancer and cancer-relevant regulators of cell proliferation, death, migration, and immune response
( Nature Research , 2021 , Article)Clinical reports show that the management of cancer patients infected with SARS-CoV-2 requires modifications. Understanding of cancer-relevant mechanisms engaged by the virus is essential for the evidence-based management ... -
Differential response of oxidative and glycolytic skeletal muscle fibers to mesterolone
( Nature Research , 2021 , Article)Oxidative and glycolytic muscle fibers differ in their ultrastructure, metabolism, and responses to physiological stimuli and pathological insults. We examined whether these fibers respond differentially to exogenous ... -
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
( Nature Research , 2022 , Article)The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) ... -
Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale
( Nature Research , 2020 , Article)Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes. Commonly used RV association tests have limited scope to leverage variant functions. We propose ... -
The epidemic volatility index, a novel early warning tool for identifying new waves in an epidemic
( Nature Research , 2021 , Article)Early warning tools are crucial for the timely application of intervention strategies and the mitigation of the adverse health, social and economic effects associated with outbreaks of epidemic potential such as COVID-19. ... -
KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals
( Nature Research , 2021 , Article)Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the smallest being Ca2+ puffs, which arise from coordinated openings of a few clustered IP3Rs. Cells express thousands of mostly mobile ... -
Meeting sustainable development goals via robotics and autonomous systems
( Nature Research , 2022 , Article)Robotics and autonomous systems are reshaping the world, changing healthcare, food production and biodiversity management. While they will play a fundamental role in delivering the UN Sustainable Development Goals, associated ... -
Methodological considerations for identifying multiple plasma proteins associated with all-cause mortality in a population-based prospective cohort
( Nature Research , 2021 , Article)Novel methods to characterize the plasma proteome has made it possible to examine a wide range of proteins in large longitudinal cohort studies, but the complexity of the human proteome makes it difficult to identify robust ... -
Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function
( Nature Research , 2023 , Article)Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the ... -
The power of genetic diversity in genome-wide association studies of lipids
( Nature Research , 2021 , Article)Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treatment, in ... -
Shotgun-based proteomics of extracellular vesicles in Alzheimer’s disease reveals biomarkers involved in immunological and coagulation pathways
( Nature Research , 2021 , Article)Alzheimer’s disease (AD) is the most common form of dementia and without readily available clinical biomarkers. Blood-derived proteins are routinely used for diagnostics; however, comprehensive plasma profiling is challenging ... -
Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer.
( Nature Research , 2020 , Article)The deregulated genes in colorectal cancer (CRC) vary significantly across different studies. Thus, a systems biology approach is needed to identify the co-deregulated genes (co-DEGs), explore their molecular networks, and ... -
The therapeutic effects of adipose-derived mesenchymal stem cells on obesity and its associated diseases in diet-induced obese mice
( Nature Research , 2021 , Article)Obesity is a global public health concern associated with increased risk of several comorbidities. Due to the limited effectiveness of current therapies, new treatment strategies are needed. Our aim was to examine the ...
