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The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.
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Springer Nature
, 2020 , Article)
Kaufman oculocerebrofacial syndrome (KOS) is a severe autosomal recessive disorder characterized by intellectual disability, developmental delays, microcephaly, and characteristic dysmorphisms. Biallelic mutations of UBE3B, ...
Chemical characterization and anti-hemolytic anemia potentials of tin nanoparticles synthesized by a green approach for bioremediation applications
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John Wiley & Sons, Ltd
, 2020 , Article)
The therapeutic properties of tin nanoparticles have been proved in recent years. One of their probable effects is anti-anemia. In this study, tin nanoparticles were synthesized and characterized in aqueous medium using ...
Colonial management of death
(
SAGE Publications
, 2020 , Article)
During the late 1960s, Israel had a policy of withholding Palestinian corpses in secret cemeteries, in which each corpse was designated by a number, called the ‘secret cemeteries of numbers’. During the last Palestinian ...
Duration of symptoms is the only predictor of testicular salvage following testicular torsion in children: A case-control study
(
Elsevier
, 2020 , Article)
ObjectiveTesticular torsion (TT) is an emergency requiring a prompt diagnosis and surgery to avoid irreversible changes and a complete loss of testis. The present study aimed to identify potential factors that may be predict ...
Phospholipase C zeta profiles are indicative of optimal sperm parameters and fertilisation success in patients undergoing fertility treatment.
(
wiley
, 2020 , Article)
Oocyte activation is driven by intracellular calcium (Ca ) oscillations induced by sperm-specific PLCζ, abrogation of which causes oocyte activation deficiency in humans. Clinical PLCζ investigations have been limited to ...
Nanotoxicology of dendrimers in the mammalian heart: Ex vivo and in vivo administration of g6 pamam nanoparticles impairs recovery of cardiac function following ischemia-reperfusion injury
(
Dove Medical Press Ltd.
, 2020 , Article)
Aim: The effects of polyamidoamine (PAMAM) dendrimers on the mammalian heart are not completely understood. In this study, we have investigated the effects of a sixth-generation cationic dendrimer (G6 PAMAM) on cardiac ...
A possible role for inducible arginase isoform (AI) in the pathogenesis of chronic venous leg ulcer
(
Wiley
, 2020 , Article)
Chronic venous ulcer (CVU) is a major cause of chronic wounds of lower extremities and presents a significant financial and resource burden to health care systems worldwide. Defects in the vasculature, matrix deposition, ...
Comparison of the biomarkers for targeted therapies in primary extra-mammary and mammary Paget's disease.
(
Wiley Open Access
, 2020 , Article)
Primary Extra-mammary Paget's disease (EMPD) is a very rare cutaneous adenocarcinoma affecting anogenital or axillary regions. It is characterized by a prolonged course with recurrences and eventually distant metastatic ...
Novel targetable biomarkers in clear cell carcinoma of the breast uncovered by molecular profiling: A study of nine cases.
(
Wiley
, 2020 , Article)
We profiled nine pure clear cell carcinomas of the breast using massively parallel DNA and RNA sequencing (NGS), in situ hybridization (ISH), and immunohistochemistry (IHC). All cases were primary mammary clear cell ...
Identification of an amino-terminus determinant critical for ryanodine receptor/Ca2+ release channel function.
(
Oxford University Press
, 2020 , Article)
The cardiac ryanodine receptor (RyR2), which mediates intracellular Ca2+ release to trigger cardiomyocyte contraction, participates in development of acquired and inherited arrhythmogenic cardiac disease. This study was ...