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Drug Repurposing in Vasculo-metabolic Diseases
(
Bentham Science Publishers
, 2023 , Other)
Drug repurposing or repositioning is an approach that seeks to maximize the use of existing drugs by identifying
new indications other than the ones for which the drug was initially conceived [1-5]. This approach has been ...
A comparative study on chemical profiles and biological activities of different extracts of three Verbascum species from Turkey: In vitro, in silico and network pharmacological approaches
(
Elsevier
, 2023 , Article)
The present study aimed to evaluate the antioxidant and enzyme inhibition properties of aerial part of Verbascum cheiranthifolium Boiss. V. myriocarpum Boiss. & Heldr. and V. pyroliforme (Boiss. & Heldr.) Kuntze as well ...
A Chromosome 9p24.1 Amplification in Colorectal Cancer with Metastases to the Kidney and Adrenal Gland: A Case Report
(
karger
, 2023 , Article)
Colorectal cancer (CRC) is the third leading cause of mortality worldwide. The Food and Drug Administration recently designated pembrolizumab, an immune checkpoint inhibitor (ICI) against a programmed death-1 receptor, as ...
Effect of Bariatric Surgery on Serum Amyloid A Protein: a Systematic Review and Meta-analysis
(
springer link
, 2023 , Article)
Background: Obesity is a chronic inflammatory condition and this meta-analysis evaluated the impact of bariatric surgery on SAA. Methods: Studies included all types of bariatric surgery where SAA was measured before and ...
Pre-prandial plasma liver-expressed antimicrobial peptide 2 (LEAP2) concentration in humans is inversely associated with hunger sensation in a ghrelin independent manner
(
Springer Science and Business Media Deutschland GmbH
, 2023 , Article)
Purpose
The liver-expressed antimicrobial peptide 2 (LEAP2) is a newly recognized peptide hormone that acts via the growth hormone secretagogue receptor (GHSR) blunting the effects of ghrelin and displaying ghrelin-independent ...
Estrogen receptor and the gender bias in Raynaud's phenomenon.
(
Bentham Science Publishers
, 2023 , Other)
Cold-induced vasoconstriction is a normal physiological reaction aiming at redirecting blood into internal more vital body organs [1]. It is mediated by sympathetic release of norepinephrine as well as by local effectors ...
Advancing Artificial Intelligence for Clinical Knowledge Retrieval: A Case Study Using ChatGPT-4 and Link Retrieval Plug-In to Analyze Diabetic Ketoacidosis Guidelines.
(
Springer
, 2023 , Article)
Introduction This case study aimed to enhance the traceability and retrieval accuracy of ChatGPT-4 in medical text by employing a step-by-step systematic approach. The focus was on retrieving clinical answers from three ...
Thermogenic Modulation of Adipose Depots: A Perspective on Possible Therapeutic Intervention with Early Cardiorenal Complications of Metabolic Impairment
(
American Society for Pharmacology and Experimental Therapy (ASPET)
, 2023 , Article)
Cardiovascular complications of diabetes and obesity remain a major cause for morbidity and mortality worldwide. Despite significant advances in the pharmacotherapy of metabolic disease, the available approaches do not ...
GPER Acts Through the cAMP/Epac/JNK/AP-1 Pathway to Induce Transcription of Alpha 2C Adrenoceptor in Human Microvascular Smooth Muscle Cells
(
Wolters Kluwer Health
, 2023 , Article)
Raynaud's phenomenon, which results from exaggerated cold-induced vasoconstriction, is more prevalent in females than males. We previously showed that estrogen increases the expression of alpha 2C-adrenoceptors (α2C-AR), ...
Mental health legislation in the Arab countries
(
Elsevier
, 2023 , Other)
Policy and legislation in Arab countries: Arab countries is a term that refers to the Middle East and North Africa (MENA) region's collective identity, reflecting cohesive socio-cultural and Islamic perspectives and ...