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    Effect of Bariatric Surgery on Serum Amyloid A Protein: a Systematic Review and Meta-analysis

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    Date
    2023-11-01
    Author
    Jamialahamdi, Tannaz
    Mirhadi, Elaheh
    Atkin, Stephen L.
    le Roux, Carel W.
    Kroh, Matthew
    Almahmeed, Wael
    Eid, Ali H.
    Sahebkar, Amirhossein
    ...show more authors ...show less authors
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    Abstract
    Background: Obesity is a chronic inflammatory condition and this meta-analysis evaluated the impact of bariatric surgery on SAA. Methods: Studies included all types of bariatric surgery where SAA was measured before and after the surgical procedure. Results: Meta-analysis of 11 clinical studies (n = 394 individuals) confirmed a significant reduction in SAA following bariatric surgery (SMD: − 0.971, 95% CI: − 2.721, 0.779, p < 0.001). Meta-regression did not show any association between the changes in BMI and the absolute difference in SAA levels. No relationship between the changes in SAA and the length of follow-up was found. Conclusion: Bariatric surgery significantly improved SAA. The decrease in SAA was not related to time after surgery or changes in BMI. Bariatric surgery may thus have an independent effect on SAA. Graphical Abstract: [Figure not available: see fulltext.].
    URI
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85173057861&origin=inward
    DOI/handle
    http://dx.doi.org/10.1007/s11695-023-06830-w
    http://hdl.handle.net/10576/49317
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    • Medicine Research [‎1794‎ items ]

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