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Dishevelled family proteins in serous ovarian carcinomas: A clinicopathologic and molecular study
(
Wiley
, 2019 , Article)
Dishevelled family proteins (DVL1, DVL2 and DVL3) are cytoplasmic mediators involved in canonical and non-canonical Wnt signaling that are important for embryonic development. Since Wnt signaling promotes cell proliferation ...
Titanium Nanorods Loaded PCL Meshes with Enhanced Blood Vessel Formation and Cell Migration for Wound Dressing Applications.
(
Wiley
, 2019 , Article)
Proper management of nonhealing wounds is an imperative clinical challenge. For the effective healing of chronic wounds, suitable wound coverage materials with the capability to accelerate cell migration, cell proliferation, ...
A generalized pairwise modelling framework for network meta-analysis.
(
Lippincott, Williams & Wilkins
, 2018 , Article)
Indirect comparison methods are used to measure the effect of two treatments that were each compared against a similar control group in a meta-analysis. The network meta-analysis method extends this to multiple treatments ...
Efficacy of Anthelminthic Drugs and Drug Combinations Against Soil-transmitted Helminths: A Systematic Review and Network Meta-analysis.
(
Oxford University Press
, 2019 , Article)
Periodic mass distribution of benzimidazole anthelminthic drugs is the key strategy to control soil-transmitted helminths (STHs) globally. However, benzimidazoles have low efficacy against Trichuris trichiura, and there ...
The risk of developing major depression among individuals with subthreshold depression: a systematic review and meta-analysis of longitudinal cohort studies.
(
Cambridge University Press
, 2019 , Article)
Studies have consistently shown that subthreshold depression is associated with an increased risk of developing major depression. However, no study has yet calculated a pooled estimate that quantifies the magnitude of this ...
The robust error meta-regression method for dose-response meta-analysis.
(
Lippincott, Williams & Wilkins
, 2018 , Article)
Dose-response meta-analysis has been widely employed in evidence-based decision-making. Currently, the most popular approach is the one or two-stage generalized least squares for trend model. This approach however has some ...
Hypotension: An unusual presentation of vitamin B 12 deficiency, with complete recovery following cyanocobalamin therapy
(
BMJ Publishing Group
, 2019 , Article)
Vitamin B 12 deficiency and its sequelae are well described and reported, especially in vegetarians. However, its association with haemodynamic instability is not well identified. We report a case of a young man, previously ...
Genome-wide polygenic score, clinical risk factors, and long-term trajectories of coronary artery disease
(
American Heart Association
, 2020 , Article)
OBJECTIVE: To determine the relationship of a genome-wide polygenic score for coronary artery disease (GPSCAD) with lifetime trajectories of CAD risk, directly compare its predictive capacity to traditional risk factors, ...
Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale
(
Nature Research
, 2020 , Article)
Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes. Commonly used RV association tests have limited scope to leverage variant functions. We propose ...
Transethnic Transferability of a Genome-wide Polygenic Score for Coronary Artery Disease.
(
American Heart Association
, 2020 , Article)
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