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Comparative efficacy and safety of PD-1/PD-L1 inhibitors in triple negative breast cancer: a systematic review and network meta-analysis of randomized controlled trials.
(
BioMed Central
, 2023 , Article)
Triple-Negative Breast Cancer (TNBC) is a lethal subtype of breast cancer with limited treatment options. The purpose of this Network Meta-Analysis (NMA) is to compare the efficacy and safety of inhibitors of programmed ...
Prevalence and global trends of polypharmacy in patients with chronic kidney disease: A systematic review and meta-analysis
(
Frontiers Media S.A.
, 2023 , Article)
Background and objectives: Polypharmacy and chronic kidney disease (CKD) are becoming increasingly common due to an ageing population and the rise of multimorbidity. In line with the therapeutic guidelines, managing CKD ...
The Arabic Questionnaire for Psychotic Experiences in patients with psychotic disorders: a clinical validation
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BioMed Central Ltd
, 2023 , Article)
Background: Psychotic experiences are reported in the general population. The Questionnaire for Psychotic Experiences (QPE) was created to test the phenomenological features of these experiences and compare them with those ...
Association Between Metabolic Syndrome and Decline in Cognitive Function: A Cross-Sectional Study
(
Dave Medical Press Limited,
, 2023 , Article)
Aim: We investigated whether metabolic syndrome (MetS) is associated with a decline in cognitive function in a cohort of middle-aged and elderly individuals without known cognitive dysfunction diseases in Qatar. Methods: ...
Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function
(
Nature Research
, 2023 , Article)
Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the ...
ApoM binds endotoxin contributing to neutralization and clearance by High Density Lipoprotein.
(
Elsevier
, 2023 , Article)
HDL possesses anti-inflammatory properties, however, the exact mechanism is not fully understood. Endotoxin is a potent inducers of TLR4 signaling, leading to inflammatory mediators' release. It has been estimated that ...
Sickness absenteeism among primary health care workers in Qatar before and during the COVID-19 pandemic
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BioMed Central Ltd
, 2023 , Article)
Objectives: To explore the patterns, trends, nature, and extent of changes in sickness absence among health care workers (HCWs) at the Primary Health Care Corporation (PHCC) in Qatar-during the COVID-19 pandemic compared ...
Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy
(
BioMed Central Ltd
, 2023 , Article)
Background: The mechanism of tumor immune escape and progression in colorectal cancer (CRC) is widely investigated in-vitro to help understand and identify agents that might play a crucial role in response to treatment and ...
Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
(
MDPI
, 2023 , Article)
Cancer is the second most life-threatening disease and has become a global health and economic problem worldwide. Due to the multifactorial nature of cancer, its pathophysiology is not completely understood so far, which ...
The Association Between Inflammatory Bowel Disease and Exposure to Tobacco Smoking: A Case-Control Study in Qatar
(
Dove Medical Press
, 2023 , Article)
Objective: This research investigated the association between childhood and adulthood tobacco smoking exposure with ulcerative colitis (UC) and Crohn’s disease (CD) in Qatar. Study Design and Setting: In this case-control ...