Medicine Research: Recent submissions
Now showing items 1381-1400 of 1739
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Continuity of sleep problems from adolescence to young adulthood: results from a longitudinal study
( Elsevier Inc , 2017 , Article)Background Considering the lack of evidence on incidence and continuity of sleep problems from adolescence to young adulthood, this study explores sleep problems’ incidence and their continuation rates from 14 to 21 ... -
Synergistic antipruritic effects of gamma aminobutyric acid A and B agonists in a mouse model of atopic dermatitis
( Mosby Inc. , 2017 , Article)Background Despite recent insights into the pathophysiology of acute and chronic itch, chronic itch remains an often intractable condition. Among major contributors to chronic itch is dysfunction of spinal cord gamma ... -
Signaling diversity of mu- and delta- opioid receptor ligands: Re-evaluating the benefits of β-arrestin/G protein signaling bias.
( Elsevier , 2020 , Article)Opioid analgesics are elective for treating moderate to severe pain but their use is restricted by severe side effects. Signaling bias has been proposed as a viable means for improving this situation. To exploit this ... -
A large, highly vascularized sacrococcygeal teratoma in a preterm male infant: A case report.
( Elsevier , 2021 , Article)Sacrococcygeal teratoma (SCT) is a rare tumor with an incidence of 1:35.000/40.000 live births. SCTs are composed of both cystic and solid components. Predominantly cystic SCTs are more likely to be benign and have a better ... -
Breast Cancer During Pregnancy: A Marked Propensity to Triple-Negative Phenotype.
( Frontiers Media , 2020 , Article)Breast and cervical cancers comprise 50% of all cancers during pregnancy. In particular, gestational breast cancer is considered one of the most aggressive types of cancers, which is a rare but fatal disease. However, the ... -
Quality versus Risk-of-Bias assessment in clinical research
( Elsevier , 2021 , Article)Assessment of internal validity safeguards implemented by researchers has been used to examine the potential reliability of evidence generated within a study. These safeguards protect against systematic error, and such an ... -
Editorial: Immune-Modulatory Effects of Vitamin D
( Frontiers Media , 2020 , Article)Vitamin D plays an essential role in bone development. However, recent studies are beginning to uncover its role as a modulator of the immune system (1). Several reports have shown associations between vitamin D deficiency ... -
The role of soluble uric acid in modulating autophagy flux and inflammasome activation during bacterial infection in macrophages
( MDPI , 2020 , Article)© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Autophagy is a homeostatic process that regulates and recycles intracellular structures and is a host defense mechanism that facilitates bacterial clearance. Uric ... -
Meningococcal Vaccines: Challenges and Prospects.
( MDPI , 2020 , Article)is a gram-negative bacterium that causes a severe acute infection, called the meningococcal disease [...]. -
The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.
( Springer Nature , 2020 , Article)Kaufman oculocerebrofacial syndrome (KOS) is a severe autosomal recessive disorder characterized by intellectual disability, developmental delays, microcephaly, and characteristic dysmorphisms. Biallelic mutations of UBE3B, ... -
Congenital microcephaly-linked CDK5RAP2 affects eye development
( Wiley , 2020 , Article)Biallelic mutations in the cyclin-dependent kinase 5 regulatory subunit-associated protein 2 gene CDK5RAP2 cause autosomal recessive primary microcephaly type 3 (MCPH3). MCPH is characterized by intellectual disability and ... -
Abnormal brain structure and behavior in MyD88-deficient mice.
( Elsevier , 2021 , Article)While the original protein Toll in Drosophila melanogaster regulates both host defense and morphogenesis, the role of its ortholog Toll-like receptors (TLRs), the interleukin 1 receptor (IL-1R) family, and the associated ... -
A new method for synthesizing test accuracy data outperformed the bivariate method
( Elsevier , 2020 , Article)This paper outlines the development of a new method (split component synthesis; SCS) for meta-analysis of diagnostic accuracy studies and assesses its performance against the commonly used bivariate random effects model. ... -
Assessment of the Role of Serum 25-Hydroxy Vitamin D Level on Coronary Heart Disease Risk With Stratification Among Patients With Type 2 Diabetes Mellitus
( SAGE Publications , 2020 , Article)© The Author(s) 2020. We investigated the role of vitamin D on glycemic regulation and cardiac complications in patients with type 2 diabetes mellitus (T2DM). A total of 1139 patients (49.3% males vs 50.7% females) were ... -
A Successful Treatment of Encapsulating Peritoneal Sclerosis in an Adolescent Boy on Long-term Peritoneal Dialysis: A Case Report.
( First Faculty of Medicine Charles University , 2020 , Article)Encapsulating peritoneal sclerosis (EPS) is a rare life-threatening complication associated with peritoneal dialysis (PD). EPS is characterized by progressive fibrosis and sclerosis of the peritoneum, with the formation ... -
Advances in Cardiovascular Biomarker Discovery.
( MDPI , 2020 , Article Review)Cardiovascular diseases are the leading causes of mortality worldwide. Among them, hypertension and its pathological complications pose a major risk for the development of other cardiovascular diseases, including heart ... -
L5 Spinal Nerve Axotomy Induces Distinct Electrophysiological Changes in Axotomized L5- and Adjacent L4-Dorsal Root Ganglion Neurons in Rats .
( Mary Ann Liebert , 2020 , Article)Peripheral neuropathic pain (PNP) is a major health problem for which effective drug treatment is lacking. Its underlying neuronal mechanisms are still illusive, but pre-clinical studies using animal models of PNP including ... -
Umbelliferone inhibits spermatogenic defects and testicular injury in lead-intoxicated rats by suppressing oxidative stress and inflammation, and improving Nrf2/HO-1 signaling
( Dove Medical Press , 2020 , Article)© 2020 Alotaibi et al. Introduction: Lead (Pb) is an environmental toxic metal that threatens human health. Umbelliferone (UMB) is a coumarin with known medicinal and protective properties against cytotoxicity. This study ... -
Changes in expression of Kv7.5 and Kv7.2 channels in dorsal root ganglion neurons in the streptozotocin rat model of painful diabetic neuropathy
( Elsevier , 2020 , Article)Diabetic peripheral neuropathic pain (DPNP), the most debilitating complication of diabetes mellitus, is resistant to current therapy. The pathogenesis of DPNP is still elusive, but several mechanisms have been proposed ... -
Immunofluorescence Staining of Paraffin Sections Step by Step.
( Frontiers Media , 2020 , Article)Immunofluorescence staining is the most frequently applied technique to detect and visualize various molecules in biological samples. Many protocols can be found in the literature and the websites of commercial antibody ...
