Medicine Research: Recent submissions
Now showing items 1321-1340 of 1739
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Gravitational Influence on Human Living Systems and the Evolution of Species on Earth
( MDPI , 2021 , Article Review)Gravity constituted the only constant environmental parameter, during the evolutionary period of living matter on Earth. However, whether gravity has affected the evolution of species, and its impact is still ongoing. The ... -
Intestinal obstruction caused by a clamped persistent omphalomesenteric duct in congenital hernia into the umbilical cord.
( Wiley , 2021 , Article)A congenital hernia into the umbilical cord (CHUM) is often misinterpreted as a mild form of omphalocele. Herniated content in CHUM can be either the solitary intestinal loop or persistent omphalomesenteric duct (POMD) ... -
Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways
( Elsevier , 2021 , Article)HER2-positive breast cancer is one of its most challenging subtypes, forming around 15–25% of the total cases. It is characterized by aggressive behavior and treatment resistance. On the other hand, poly (amidoamine) (PAMAM) ... -
Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment.
( Springer , 2021 , Article)Metabolic dysregulation in the hypoxic tumor microenvironment (TME) is considered as a hallmark of solid tumors, leading to changes in biosynthetic pathways favoring onset, survival and proliferation of malignant cells. ... -
Exploring the effect of image enhancement techniques on COVID-19 detection using chest X-ray images
( Elsevier , 2021 , Article)Computer-aided diagnosis for the reliable and fast detection of coronavirus disease (COVID-19) has become a necessity to prevent the spread of the virus during the pandemic to ease the burden on the healthcare system. Chest ... -
Microneedles: A new generation vaccine delivery system
( MDPI , 2021 , Article Review)Transdermal vaccination route using biodegradable microneedles is a rapidly progressing field of research and applications. The fear of painful needles is one of the primary reasons most people avoid getting vaccinated. ... -
An Early Warning Tool for Predicting Mortality Risk of COVID-19 Patients Using Machine Learning
( Springer , 2021 , Article)COVID-19 pandemic has created an extreme pressure on the global healthcare services. Fast, reliable, and early clinical assessment of the severity of the disease can help in allocating and prioritizing resources to reduce ... -
Information, Thermodynamics and Life: A Narrative Review
( MDPI , 2021 , Article Review)Information is probably one of the most difficult physical quantities to comprehend. This applies not only to the very definition of information, but also to the physical entity of information, meaning how can it be ... -
Oncoproteins of High-Risk HPV and EBV Cooperate to Enhance Cell Motility and Invasion of Human Breast Cancer Cells Erk1/Erk2 and β-Catenin Signaling Pathways.
( Frontiers Media , 2021 , Article)Breast cancer is a leading cause of death in women around the world. Most breast cancer-related deaths are a result of complications from the metastatic spread. Several recent studies reported that high-risk human ... -
Regulation of NKG2D by RKIP: Implications on NK-mediated cytotoxicity and cytokine production
( Elsevier , 2021 , Book chapter)RKIP (Raf kinase inhibitory protein) is a metastatic suppressor and a chemo-immuno-sensitizer. The deficiency or loss of RKIP has been linked with different cancer types, resulting in the activation of the MAPK pathway, ... -
Personalized telehealth in the future: A global research agenda
( JMIR Publications Inc. , 2016 , Article Review)As telehealth plays an even greater role in global health care delivery, it will be increasingly important to develop a strong evidence base of successful, innovative telehealth solutions that can lead to scalable and ... -
Isolated deep orbital hemangioma treated successfully with oral propranolol in a 2-month-old infant: Case report with literature review
( Elsevier , 2021 , Article)Purpose Infantile hemangiomas (IH) are the most common benign vascular tumors of infancy. Ocular complications due to orbital IH include strabismal, deprivational, or anisometropic astigmatism, and visual loss secondary ... -
The Effects of Ranitidine Treatment on the Risk of Necrotizing Enterocolitis in Preterm Infants: A Case-Control Study.
( Faculty of Medicine - Hradec Králové - Karolinum Press , 2021 , Article)Gastric acidity plays an important role in the protection of infants against various pathogens from the environment. The histamine-2 receptor blockers (H2-blockers) are off-labeled drugs that are frequently prescribed in ... -
The complete spectrum of pentalogy of Cantrell in one of a set of dizygotic twins: A case report of a rare congenital anomaly.
( Lippincott, Williams & Wilkins , 2021 , Article)Pentalogy of Cantrell (POC) is an extremely rare syndrome with an estimated incidence of 1:65,000 to 200,000 live births. Its complete form includes a midline epigastric abdominal wall defect, defects affecting the lower ... -
A comparison of the prevalence of sexually transmitted infections among circumcised and uncircumcised adult males in Rustenburg, South Africa: a cross-sectional study.
( BMC , 2021 , Article)South Africa has a persistent burden of sexually transmitted infections (STIs). Male circumcision has been shown to be effective in preventing HIV and STIs, but data are scarce on the protective effect of circumcision in ... -
Mutations in PLCδ1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function
( Blackwell Publishing Ltd , 2016 , Article)Hereditary leukonychia is a rare genetic nail disorder characterized by distinctive whitening of the nail plate of all 20 nails. Hereditary leukonychia may exist as an isolated feature, or in simultaneous occurrence with ... -
Targeted delivery of rifampicin to tuberculosis-infected macrophages: design, in-vitro, and in-vivo performance of rifampicin-loaded poly(ester amide)s nanocarriers
( Elsevier B.V. , 2016 , Article)We have developed a nano drug delivery system for the treatment of tuberculosis (TB) using rifampicin (RF) encapsulated in poly(ester amide)s nanoparticles (PEA-RF-NPs), which are biocompatible polymers. In this study, ... -
Metformin is comparable to insulin for pharmacotherapy in gestational diabetes mellitus: A network meta-analysis evaluating 6046 women.
( Elsevier , 2021 , Article)The comparative efficacy of gestational diabetes (GDM) treatments lack conclusive evidence for choice of first-line treatment. The aim of this study was to compare the efficacy of metformin and glibenclamide to insulin ... -
In-frame fusion of SUMO1 enhances βarrestin2's association with activated GPCRs as well as with nuclear pore complexes
( Elsevier , 2020 , Article)Small ubiquitin like modifier (SUMO) conjugation or SUMOylation of βarrestin2 promotes its association with the clathrin adaptor protein AP2 and facilitates rapid β2 adrenergic receptor (β2AR) internalization. However, ... -
Prevalence and Phylogenetic Analysis of Parvovirus (B19V) among Blood Donors with Different Nationalities Residing in Qatar
( MDPI , 2021 , Article)Human parvovirus (B19V) is the causative agent of erythema infectiosum in children and is linked to a wide range of clinical manifestations. Studies related to B19V prevalence in the Middle East and North Africa (MENA) ...
