Medicine Research: Recent submissions
Now showing items 1341-1360 of 1739
-
Distinct genomic features across cytolytic subgroups in skin melanoma.
( Springer , 2021 , Article)Skin melanoma is a highly immunogenic cancer. The intratumoral immune cytolytic activity (CYT) reflects the ability of cytotoxic T and NK cells to eliminate cancer cells, and is associated with improved patient survival. ... -
Biased agonism at G protein-coupled receptors
( Elsevier , 2021 , Article)G protein-coupled receptors (GPCRs) represent the largest family of approved therapeutic targets. Ligands stimulating these receptors specifically activate multiple signalling pathways that induce not only the desired ... -
SARS-CoV-2 Infection and Smoking: What is the association? A brief review
( Elsevier , 2021 , Article)Susceptibility to severe illness from COVID-19 is anticipated to be associated with cigarette smoking as it aggravates the risk of cardiovascular and respiratory illness, including infections. This is particularly important ... -
Preputial balanitis xerotica obliterans shortly after hand, foot and mouth disease in a 5-year-old boy: Coincidence or consequence?
( Elsevier , 2021 , Article)Balanitis xerotica obliterans (BXO), a genital form of lichen sclerosus (LS) in males, is a progressive, sclerosing, inflammatory dermatosis affecting the foreskin, frenulum, glans penis, meatus, and urethra. BXO was ... -
Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity
( Elsevier , 2021 , Article)Obesity is a global burden and a chronic ailment with damaging overall health effects. Ghrelin, an octanoylated 28 amino acid peptide hormone, is secreted from the oxyntic mucosa of the stomach. Ghrelin acts on regions of ... -
Effects of topiramate on pregnancy outcome in rats
( Bahrain Medical Bulletin , 2016 , Article)Background: Anti-epileptics taken during pregnancy might lead to low birth-weight and birth defects which could be associated with neonatal morbidity and mortality. Objective: To evaluate the effects of maternal exposure ... -
Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis
( Oxford University Press , 2021 , Article)Although immune checkpoint inhibition (ICI) has shown promising results in metastatic dMMR/MSI-H colorectal cancer (CRC), the majority of pMMR/MSS patients do not respond to such therapies. To systematically evaluate the ... -
DEFECTIVE NATURAL KILLER CELLS IN MELANOMA: ROLE OF NKG2D IN THE PATHOGENESIS AND IMMUNOTHERAPY
( Begell House , 2021 , Article)Melanoma is the most aggressive and deadliest form of skin cancer, and its prognosis is very poor. While the early detection is responsive to many treatments, metastatic melanoma is refractory to most of them. In the USA, ... -
The store-operated Ca entry complex comprises a small cluster of STIM1 associated with one Orai1 channel.
( National Academy of Sciences , 2021 , Article)Increases in cytosolic Ca concentration regulate diverse cellular activities and are usually evoked by opening of Ca channels in intracellular Ca stores and the plasma membrane (PM). For the many signals that evoke formation ... -
IP3 receptors and their intimate liaisons
( Elsevier , 2020 , Article Review)Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular Ca2+ channels. They allow cell-surface receptors that stimulate IP3 formation to evoke rapid Ca2+ release from the endoplasmic reticulum (ER). IP3Rs initiate ... -
Occupational exposure to HIV among nurses at a major tertiary hospital: Reporting and utilization of post-exposure prophylaxis; A cross-sectional study in the Western Cape, South Africa
( Public Library of Science , 2020 , Article)© 2020 Kabotho, Chivese. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ... -
Outcomes of hyperglycaemia in pregnancy in Africa: Systematic review study protocol
( BMJ Publishing Group , 2021 , Article)Introduction The prevalence of diabetes mellitus globally has increased considerably over the past decades with a resultant increase in the incidence of diabetes-complicated pregnancies. Hyperglycaemia in pregnancy is the ... -
TERT gene fusions characterize a subset of metastatic Leydig cell tumors
( Elsevier , 2021 , Article)Objective: Metastatic Leydig cell tumors (LCT) are rare, difficult to treat malignancies without known underlying molecular-genetic events. An index case of metastatic LCT showed an LDLR-TERT gene fusion upon routine genetic ... -
A proposed framework to guide evidence synthesis practice for meta-analysis with zero-events studies
( Elsevier , 2021 , Article)ObjectiveIn evidence synthesis practice, researchers often face the problem of how to deal with zero-events. Inappropriately dealing with zero-events studies may lead to research waste and mislead healthcare practice. We ... -
Neuronal Cell Types in the Anterior Ventral Thalamic Nucleus of the Camel.
( Wiley , 2021 , Article)The anterior ventral nucleus neurons in of the camel brain were morphologically studied by Golgi impregnation method. Two neuronal types of were found in the camel anterior ventral thalamic nucleus, namely, Golgi-type I ... -
Demographic and Clinical Characteristics of Early Travel-Associated COVID-19 Cases
( Frontiers Media , 2020 , Article)© Copyright © 2020 Marei, Emara, Elsaied, Nasrallah, Chivese, Al-Romaihi, Althani, Al Thani, Farag and Yassine. Background: SARS-CoV-2 continues to claim hundreds of thousands of people's lives. It mostly affects the elderly ... -
Identification of Co-Deregulated Genes in Urinary Bladder Cancer Using High-Throughput Methodologies
( MDPI , 2021 , Article)Urinary bladder cancer (UBC) is the second most common urogenital solid tumor and the eleventh in the rank among all types of solid tumors. Although several oncogenes and tumor suppressors are known to be implicated in the ... -
Accuracies of discriminant function equations for sex estimation using long bones of upper extremities
( Springer , 2020 , Article)© 2020, Springer-Verlag GmbH Germany, part of Springer Nature. One of the scopes of practice of forensic anthropologists is the estimation of sex from skeletal remains. As a result, population-specific discriminant function ... -
Estimation of sex from the metacarpal dimensions at the nutrient foramen in white South Africans
( Taylor and Francis , 2020 , Article)© 2020 Australian Academy of Forensic Sciences. Sex estimation is important in both forensic and archaeological cases and requires a variety of bones and measurements to obtain accurate estimates. Discriminant function ... -
Avoidability of drug-induced liver injury (DILI) in an elderly hospital cohort with cases assessed for causality by the updated RUCAM score
( BMC , 2020 , Article)© 2020 The Author(s). Background: Drug-induced liver injury (DILI) represents an increasing morbidity in the general population, but more so in the elderly cohort of patients. Despite this, the concept of its prevention ...
