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Now showing items 11-20 of 49
The Role of Protein Tyrosine Phosphatase (PTP)-1B in Cardiovascular Disease and Its Interplay with Insulin Resistance.
(
MDPI
, 2019 , Article Review)
Endothelial dysfunction is a key feature of cardiovascular disorders associated with obesity and diabetes. Several studies identified protein tyrosine phosphatase (PTP)-1B, a member of the PTP superfamily, as a major ...
Microparticles as Potential Mediators of High Glucose-Induced Renal Cell Injury.
(
MDPI
, 2019 , Article)
Diabetic nephropathy (DN) is the most common cause of chronic kidney disease worldwide. Activation of signaling pathways such as the mammalian target of rapamycin (mTOR), extracellular signal-regulated kinases (ERK), ...
Suppression of GATA-3 increases adipogenesis, reduces inflammation and improves insulin sensitivity in 3T3L-1 preadipocytes
(
Elsevier
, 2020 , Article)
© 2020 Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes. Adipose tissue inflammation is a crucial mediator of this process. GATA-3 plays important ...
Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling
(
hindawi
, 2020 , Article)
Hypertension induces vascular hypertrophy, which changes blood vessels structurally and functionally, leading to reduced tissue perfusion and further hypertension. It is also associated with dysregulated levels of the ...
Temporal cross talk between endoplasmic reticulum and mitochondria regulates oxidative stress and mediates microparticle-induced endothelial dysfunction
(
Mary Ann Liebert, Inc.
, 2017 , Article)
Aims: Circulating microparticles (MPs) from metabolic syndrome patients
and those generated from apoptotic T-cells induce endothelial
dysfunction; however, the molecular and cellular mechanism(s) underlying
in the effects ...
Interplay between Endoplasmic Reticulum Stress and Large Extracellular Vesicles (Microparticles) in Endothelial Cell Dysfunction
(
MDPI
, 2020 , Article)
Upon increased demand for protein synthesis, accumulation of misfolded and/or unfolded proteins within the endoplasmic reticulum (ER), a pro-survival response is activated termed unfolded protein response (UPR), aiming at ...
Investigating the use of a lecture capture system within pharmacy education: Lessons from an undergraduate pharmacy program at Qatar University
(
Springer
, 2020 , Article)
© 2020, The Author(s). Video lecture capture is one of the most attractive e-tools that has been introduced to support students learning and assist with grasping difficult concepts. A variety of benefits is offered through ...
An Emergency Switch to Distance Learning in Response to the COVID-19 Pandemic: Experience from an Internationally Accredited Undergraduate Pharmacy Program at Qatar University
(
Springer
, 2020 , Article)
© 2020, The Author(s). The world is experiencing an unprecedented public health emergency owing to the COVID-19 pandemic. To control virus spread, many countries temporarily suspended classes. In this context, the availability ...
BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells.
(
Dove Medical Press
, 2020 , Article)
Venetoclax (VCX) is a selective BCL-2 inhibitor approved for the treatment of leukemia and lymphoma. However, the mechanisms of anti-cancer effect of VCX either as a monotherapy or in combination with other chemotherapeutic ...
Endoplasmic Reticulum (ER) Stress-Generated Extracellular Vesicles (Microparticles) Self-Perpetuate ER Stress and Mediate Endothelial Cell Dysfunction Independently of Cell Survival.
(
Frontiers Media
, 2020 , Article)
Circulating extracellular vesicles (EVs) are recognized as biomarkers and effectors of endothelial dysfunction, the initiating step of cardiovascular abnormalities. Among these EVs, microparticles (MPs) are vesicles directly ...