تصفح Research Units حسب المؤلف "UDDIN, SHAHAB"
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Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells
Kuttikrishnan, Shilpa; Bhat, Ajaz A.; Mateo, Jericha M.; Ahmad, Fareed; Alali, Feras Q.; El-Elimat, Tamam; Oberlies, Nicholas H.; Pearce, Cedric J.; Uddin, Shahab... more authors ... less authors ( Elsevier , 2022 , Article)Neosetophomone B (NSP–B), a meroterpenoid fungal secondary metabolite, was investigated for its anticancer potential in leukemic cell lines (K562 and U937). NSP-B treatment of leukemic cells suppressed cell viability by ... -
Applications of polydopaminic nanomaterials in mucosal drug delivery
Takwa, Bedhiafi; Idoudi, Sourour; Alhams, Areej Ali; Fernandes, Queenie; Iqbal, Heba; Basineni, Renuka; Uddin, Shahab; Dermime, Said; Merhi, Maysaloun; Billa, Nashiru... more authors ... less authors ( Elsevier , 2023 , Article Review)Polydopamine (PDA) is a biopolymer with unique physicochemical properties, including free-radical scavenging, high photothermal conversion efficiency, biocompatibility, biodegradability, excellent fluorescent and theranostic ... -
Bioinformatics Analysis Reveals FOXM1/BUB1B Signaling Pathway as a Key Target of Neosetophomone B in Human Leukemic Cells: A Gene Network-Based Microarray Analysis
Kuttikrishnan, Shilpa; Masoodi, Tariq; Sher, Gulab; Bhat, Ajaz A.; Patil, Kalyani; El-Elimat, Tamam; Oberlies, Nicholas H.; Pearce, Cedric J.; Haris, Mohmmad; Ahmad, Aamir; Alali, Feras Q.; Uddin, Shahab... more authors ... less authors ( Frontiers Media S.A. , 2022 , Article)Abnormal expression of Forkhead box protein M1 (FOXM1) and serine/threonine kinase Budding uninhibited by benzimidazoles 1 (BUB1B) contributes to the development and progression of several cancers, including chronic ... -
Correction to: Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance (Molecular Cancer, (2020), 19, 1, (57), 10.1186/s12943-020-01175-9)
Bhat, Ajaz A.; Younes, Salma N.; Raza, Syed Shadab; Zarif, Lubna; Nisar, Sabah; Ahmed, Ikhlak; Mir, Rashid; Kumar, Sachin; Sharawat, Surender K.; Hashem, Sheema; Elfaki, Imadeldin; Kulinski, Michal; Kuttikrishnan, Shilpa; Prabhu, Kirti S.; Khan, Abdul Q.; Yadav, Santosh K.; El-Rifai, Wael; Zargar, Mohammad A.; Zayed, Hatem; Haris, Mohammad; Uddin, Shahab... more authors ... less authors ( BMC , 2020 , Other)Following the publication of the original article [1], authors have noticed that one of the authors, Syed Shadab Raza, was missing in the Authors’ Contributions section. Please see below updated section. -
Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis
Sharma, Tarang; Gupta, Ashna; Chauhan, Ravi; Bhat, Ajaz A.; Nisar, Sabah; Hashem, Sheema; Akhtar, Sabah; Ahmad, Aamir; Haris, Mohammad; Singh, Mayank; Uddin, Shahab... more authors ... less authors ( Springer , 2022 , Article)Esophageal cancer (EC) is frequently considered a lethal malignancy and is often identified at a later stage. It is one of the major causes of cancer-related deaths globally. The conventional treatment methods like ... -
Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy
Bhat, Ajaz A.; Nisar, Sabah; Singh, Mayank; Ashraf, Bazella; Masoodi, Tariq; Prasad, Chandra P.; Sharma, Atul; Maacha, Selma; Karedath, Thasni; Hashem, Sheema; Yasin, Syed Besina; Bagga, Puneet; Reddy, Ravinder; Frennaux, Michael P.; Uddin, Shahab; Dhawan, Punita; Haris, Mohammad; Macha, Muzafar A.... more authors ... less authors ( Wiley , 2022 , Article Review)Colorectal cancer (CRC) is a predominant life-threatening cancer, with liver and peritoneal metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor, nurtures a local inflammatory environment ... -
Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy
Bhat, A.A.; Bhat, Ajaz A.; Nisar, Sabah; Maacha, Selma; Carneiro-Lobo, Tatiana Correa; Akhtar, Sabah; Siveen, Kodappully Sivaraman; Wani, Nissar A.; Rizwan, Arshi; Bagga, Puneet; Singh, Mayank; Reddy, Ravinder; Uddin, Shahab; Grivel, Jean Charles; Chand, Gyan; Frenneaux, Michael P.; Siddiqi, Mushtaq A.; Bedognetti, Davide; El-Rifai, Wael; Macha, Muzafar A.; Haris, Mohammad... more authors ... less authors ( BMC , 2021 , Article Review)Esophageal cancer (EC) is a disease often marked by aggressive growth and poor prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant metastases among patients with advanced disease account ... -
Decoding the functional role of extracellular vesicles in hepatocellular carcinoma: implications in clinical theranostics
Kalyani, Patil; Dermime, Said; Uddin, Shahab ( Elsevier , 2022 , Book chapter)Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer in adults, the sixth most commonly diagnosed neoplasia, and the third leading cause of cancer-related deaths worldwide. Despite tangible ... -
Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines
Fernandes, Queenie; Inchakalody, Varghese Philipose; Merhi, Maysaloun; Mestiri, Sarra; Taib, Nassiba; Moustafa Abo El-Ella, Dina; Bedhiafi, Takwa; Raza, Afsheen; Al-Zaidan, Lobna; Mohsen, Mona O.; Yousuf Al-Nesf, Mariam Ali; Hssain, Ali Ait; Yassine, Hadi Mohamad; Bachmann, Martin F.; Uddin, Shahab; Dermime, Said... more authors ... less authors ( Taylor and Francis , 2022 , Article)The emergence of novel and evolving variants of SARS-CoV-2 has fostered the need for change in the form of newer and more adaptive diagnostic methods for the detection of SARS-CoV-2 infections. On the other hand, developing ... -
Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression
Reem Khaled M.E., Alsayed; Khan, Abdul Q.; Ahmad, Fareed; Ansari, Abdul Wahid; Alam, Majid Ali; Buddenkotte, Jorg; Steinhoff, Martin; Uddin, Shahab; Ahmad, Aamir... more authors ... less authors ( Elsevier , 2022 , Article)Signaling involving chemokine receptor CXCR4 and its ligand SDF-1/CXL12 has been investigated for many years for its possible role in cancer progression and pathogenesis. Evidence emerging from clinical studies in recent ... -
F-box proteins in cancer stemness: An emerging prognostic and therapeutic target
Abdul Q., Khan; Al-Tamimi, Maha; Uddin, Shahab; Steinhoff, Martin ( Elsevier , 2021 , Article)Cancer is a complex heterogenic disease with significant therapeutic challenges. The presence of cancer stem cells (CSCs) in cancer tissue orchestrates tumor growth, progression, and metastasis, the tumor heterogeneity, ... -
Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies
Nisar, Sabah; Bhat, Ajaz A.; Singh, Mayank; Karedath, Thasni; Rizwan, Arshi; Hashem, Sheema; Bagga, Puneet; Reddy, Ravinder; Jamal, Farrukh; Uddin, Shahab; Chand, Gyan; Bedognetti, Davide; El-Rifai, Wael; Frenneaux, Michael P.; Macha, Muzafar A.; Ahmed, Ikhlak; Haris, Mohammad... more authors ... less authors ( Frontiers Media , 2021 , Article Review)Circular RNAs (circRNAs) are an evolutionarily conserved novel class of non-coding endogenous RNAs (ncRNAs) found in the eukaryotic transcriptome, originally believed to be aberrant RNA splicing by-products with decreased ... -
Long non-coding RNAs regulated NF-κB signaling in cancer metastasis: Micromanaging by not so small non-coding RNAs
Shaniya, Ahmad; Abbas, Madiha; Ullah, Mohammad Fahad; Aziz, Moammir H.; Beylerli, Ozal; Alam, Majid Ali; Syed, Mansoor Ali; Uddin, Shahab; Ahmad, Aamir... more authors ... less authors ( Elsevier Ltd , 2022 , Article)Cancer metastasis is a major reason for the cancer-associated deaths and a role of long non-coding RNAs (lncRNAs) in cancer metastasis is increasingly being realized. Among the many oncogenic pathways, NF-κB signalling’s ... -
Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways
Kalyani, Patil; Kuttikrishnan, Shilpa; Khan, Abdul Q.; Ahmad, Fareed; Alam, Majid; Buddenkotte, Joerg; Ahmad, Aamir; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( Elsevier , 2022 , Article Review)Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphoproliferative neoplasms that exhibit a wide spectrum of immune-phenotypical, clinical, and histopathological features. The biology of CTCL is complex ... -
Natural resorcylic acid lactones: A chemical biology approach for anticancer activity
Shilpa, Kuttikrishnan; Prabhu, Kirti S.; Al Sharie, Ahmed H.; Al Zu'bi, Yazan O.; Alali, Feras Q.; Oberlies, Nicholas H.; Ahmad, Aamir; El-Elimat, Tamam; Uddin, Shahab... more authors ... less authors ( Elsevier , 2022 , Article)Resorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid residue (2,4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a broad range of biological activities, including ... -
Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway
Kuttikrishnan, Shilpa; Ahmad, Fareed; Mateo, Jericha M.; Prabhu, Kirti S.; El-Elimat, Tamam; Oberlies, Nicholas H.; Pearce, Cedric J.; Akil, Ammira S.Alshabeeb; Bhat, Ajaz A.; Alali, Feras Q.; Uddin, Shahab... more authors ... less authors ( Wiley-Blackwell , 2023 , Article)Multiple myeloma (MM) is a hematologic malignancy associated with malignant plasma cell proliferation in the bone marrow. Despite the available treatments, drug resistance and adverse side effects pose significant challenges, ... -
Non-Invasive Biomarkers for Early Lung Cancer Detection
Saman, Harman; Raza, Afsheen; Patil, Kalyani; Uddin, Shahab; Crnogorac-Jurcevic, Tatjana ( MDPI , 2022 , Article Review)Worldwide, lung cancer (LC) is the most common cause of cancer death, and any delay in the detection of new and relapsed disease serves as a major factor for a significant proportion of LC morbidity and mortality. Though ... -
Persistence of spike-specific immune responses in BNT162b2-vaccinated donors and generation of rapid ex-vivo T cells expansion protocol for adoptive immunotherapy: A pilot study
Mestiri, Sarra; Merhi, Maysaloun; Inchakalody, Varghese P.; Taib, Nassiba; Smatti, Maria K.; Ahmad, Fareed; Raza, Afsheen; Ali, Fatma H.; Hydrose, Shereena; Fernandes, Queenie; Ansari, Abdul W.; Sahir, Fairooz; Al-Zaidan, Lobna; Jalis, Munir; Ghoul, Mokhtar; Allahverdi, Niloofar; Al Homsi, Mohammed U.; Uddin, Shahab; Jeremijenko, Andrew Martin; Nimir, Mai; Abu-Raddad, Laith J.; Abid, Fatma Ben; Zaqout, Ahmed; Alfheid, Sameer R.; Saqr, Hassan Mohamed Hassan; Omrani, Ali S.; Hssain, Ali Ait; Al Maslamani, Muna; Yassine, Hadi M.; Dermime, Said... more authors ... less authors ( Frontiers Media , 2023 , Article)Introduction: The BNT162b2 mRNA-based vaccine has shown high efficacy in preventing COVID-19 infection but there are limited data on the types and persistence of the humoral and T cell responses to such a vaccine. Methods: ... -
The plasticity of pancreatic cancer stem cells: implications in therapeutic resistance
Patil, Kalyani; Khan, Farheen B.; Akhtar, Sabah; Ahmad, Aamir; Uddin, Shahab ( Springer Nature , 2021 , Article)The ever-growing perception of cancer stem cells (CSCs) as a plastic state rather than a hardwired defined entity has evolved our understanding of the functional and biological plasticity of these elusive components in ... -
The potential role of vitamin C in empowering cancer immunotherapy
Takwa, Bedhiafi; Inchakalody, Varghese Philipose; Fernandes, Queenie; Mestiri, Sarra; Billa, Nashiru; Uddin, Shahab; Merhi, Maysaloun; Dermime, Said... more authors ... less authors ( Elsevier , 2022 , Article)Vitamin C also known as L-ascorbic acid is a nutrient naturally occurring in many fruits and vegetables and widely known for its potent antioxidant activity. Several studies have highlighted the importance of using high ...