عرض بسيط للتسجيلة

المؤلفShaniya, Ahmad
المؤلفAbbas, Madiha
المؤلفUllah, Mohammad Fahad
المؤلفAziz, Moammir H.
المؤلفBeylerli, Ozal
المؤلفAlam, Majid Ali
المؤلفSyed, Mansoor Ali
المؤلفUddin, Shahab
المؤلفAhmad, Aamir
تاريخ الإتاحة2022-10-27T11:25:53Z
تاريخ النشر2022-10
اسم المنشورSeminars in Cancer Biology
المعرّفhttp://dx.doi.org/10.1016/j.semcancer.2021.07.015
الاقتباسAhmad, S., Abbas, M., Ullah, M. F., Aziz, M. H., Beylerli, O., Alam, M. A., ... & Ahmad, A. (2021, July). Long non-coding RNAs regulated NF-κB signaling in cancer metastasis: Micromanaging by not so small non-coding RNAs. Seminars in Cancer Biology, 85, 155-163.
الرقم المعياري الدولي للكتاب1044-579X
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S1044579X21002108
معرّف المصادر الموحدhttp://hdl.handle.net/10576/35530
الملخصCancer metastasis is a major reason for the cancer-associated deaths and a role of long non-coding RNAs (lncRNAs) in cancer metastasis is increasingly being realized. Among the many oncogenic pathways, NF-κB signalling’s involvement in cancer metastasis as a key inflammation-regulatory transcription factor has been a subject of interest for long time. Accumulating data from in vitro as well as in vivo studies along with analysis of clinical cancer tissues points to regulation of NF-κB signalling by lncRNAs with implications toward the onset of cancer metastasis. LncRNAs FOXD2-AS1, KRT19P3 and the NF-κB interacting lncRNA (NKILA) associate with lymph node metastasis and poor prognosis of individual cancers. The role of epithelial-mesenchymal transition (EMT) in cancer metastasis is well known. EMT is regulated by NF-κB and regulation of NF-κB/EMT-induced metastasis by lncRNAs remains a hot topic of research with indications for such roles of lncRNAs MALAT1, SNHG15, CRNDE and AC007271.3. Among the many lncRNAs, NKILA stands out as the most investigated lncRNA for its regulation of NF-κB. This tumor suppressive lncRNA has been reported downregulated in clinical samples representing different human cancers. Mechanistically, NKILA has been consistently shown to inhibit NF-κB activation via inhibition of IκBα phosphorylation and the resulting suppression of EMT. NKILA is also a target of natural anticancer compounds. Given the importance of NF-κB as a master regulatory transcription factor, lncRNAs, as the modulators of NF-κB signaling, can provide alternate targets for metastatic cancers with constitutively active NF-κB.
راعي المشروعOpen Access supported by the Qatar National Library.
اللغةen
الناشرElsevier Ltd
الموضوعLncRNAs
NF-κB
Metastasis
EMT
NKILA
العنوانLong non-coding RNAs regulated NF-κB signaling in cancer metastasis: Micromanaging by not so small non-coding RNAs
النوعArticle
الصفحات155-163
رقم المجلد85
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة