Guiding Factors and Surface Modification Strategies for Biomaterials in Pharmaceutical Product Development

Abstract

With the technological advent in the field of drug delivery and medicines, biomaterials become important owing to their properties such as biocompatibility, functionality, and bioactive and bioinert nature. However, the suitable designs of biomaterial closely rely on its specific application such as drug delivery, tissue engineering, or scaffold design. Understanding about the biomaterial and its role in successful pharmaceutical product development as well as its formulation strategies are important for the development of specific products. This chapter focuses on a different aspect of biomaterials in the successful development of therapeutic goods such as endosomal escape tendency, enhanced permeability and retention effect, stability, skin penetration, etc. Considering that surface modification of biomaterial may impart the desired properties for the use in biomedical applications, we also give special attention to and dictate almost all the available methods of biomaterial design and modification, such as sol-gel, electrophoretic deposition, calcium phosphate deposition, and plasma polymerization.