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المؤلفNisar, Sabah
المؤلفBhat, Ajaz A.
المؤلفMasoodi, Tariq
المؤلفHashem, Sheema
المؤلفAkhtar, Sabah
المؤلفAli, Tayyiba Akbar
المؤلفAmjad, Sara
المؤلفChawla, Sanjeev
المؤلفBagga, Puneet
المؤلفFrenneaux, Michael P.
المؤلفReddy, Ravinder
المؤلفFakhro, Khalid
المؤلفHaris, Mohammad
تاريخ الإتاحة2023-04-12T06:23:08Z
تاريخ النشر2022-05-01
اسم المنشورMolecular Psychiatry
المعرّفhttp://dx.doi.org/10.1038/s41380-022-01506-w
الاقتباسNisar, S., Bhat, A.A., Masoodi, T. et al. Genetics of glutamate and its receptors in autism spectrum disorder. Mol Psychiatry 27, 2380–2392 (2022). https://doi.org/10.1038/s41380-022-01506-w
الرقم المعياري الدولي للكتاب13594184
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85126274476&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/41840
الملخصAutism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by deficits in social interaction skills, impaired communication, and repetitive and restricted behaviors that are thought to be due to altered neurotransmission processes. The amino acid glutamate is an essential excitatory neurotransmitter in the human brain that regulates cognitive functions such as learning and memory, which are usually impaired in ASD. Over the last several years, increasing evidence from genetics, neuroimaging, protein expression, and animal model studies supporting the notion of altered glutamate metabolism has heightened the interest in evaluating glutamatergic dysfunction in ASD. Numerous pharmacological, behavioral, and imaging studies have demonstrated the imbalance in excitatory and inhibitory neurotransmitters, thus revealing the involvement of the glutamatergic system in ASD pathology. Here, we review the effects of genetic alterations on glutamate and its receptors in ASD and the role of non-invasive imaging modalities in detecting these changes. We also highlight the potential therapeutic targets associated with impaired glutamatergic pathways.
اللغةen
الناشرSpringer Nature
الموضوعGenetics
Neuroscience
العنوانGenetics of glutamate and its receptors in autism spectrum disorder
النوعArticle Review
الصفحات2380-2392
رقم العدد5
رقم المجلد27
ESSN1476-5578


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