تصفح College of Medicine حسب العنوان
السجلات المعروضة 864 -- 883 من 1378
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Mucocele of the appendix presenting as an exacerbated chronic tubo-ovarian abscess: A case report and comprehensive review of the literature.
( Lippincott, Williams & Wilkins , 2019 , Article)Appendiceal mucocele is a rare entity of mucinous cystic dilatation of the appendix. It has no typical clinical presentation and is considered a potentially premalignant condition. We present a case of accidental intraoperative ... -
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
( Elsevier , 2022 , Article)A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ... -
Multimorbidity, healthcare use and catastrophic health expenditure by households in India: a cross-section analysis of self-reported morbidity from national sample survey data 2017–18
( BMC , 2022 , Article)Background: The purpose of this research is to generate new evidence on the economic consequences of multimorbidity on households in terms of out-of-pocket (OOP) expenditures and their implications for catastrophic OOP ... -
The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.
( Springer Nature , 2020 , Article)Kaufman oculocerebrofacial syndrome (KOS) is a severe autosomal recessive disorder characterized by intellectual disability, developmental delays, microcephaly, and characteristic dysmorphisms. Biallelic mutations of UBE3B, ... -
Mutagenesis-Based Characterization and Improvement of a Novel Inclusion Body Tag
( Frontiers Media , 2020 , Article)Whereas, bacterial inclusion bodies (IBs) for long were regarded as undesirable aggregates emerging during recombinant protein production, they currently receive attention as promising nanoparticulate biomaterials with ... -
Mutations in PLCδ1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function
( Blackwell Publishing Ltd , 2016 , Article)Hereditary leukonychia is a rare genetic nail disorder characterized by distinctive whitening of the nail plate of all 20 nails. Hereditary leukonychia may exist as an isolated feature, or in simultaneous occurrence with ... -
Mutual inter-regulation between iNOS and TGF-β1: Possible molecular and cellular mechanisms of iNOS in wound healing.
( Elsevier , 2020 , Article)Abnormal wound healing with excessive scarring is a major health problem with socioeconomic and psychological impacts. In human, chronic wounds and scarring are associated with upregulation of the inducible nitric oxide ... -
MXene Nanosheets May Induce Toxic Effect on the Early Stage of Embryogenesis.
( American Scientific Publishers , 2020 , Article)MXene (Ti₃C₂T), as a novel 2D material, has produced a great interest due to its promising properties in biomedical applications, nevertheless, there is a lack of studies dedicated to investigate the possible toxic effect ... -
Mycoplasma bovis-induced inhibition of bovine peripheral blood mononuclear cell proliferation is ameliorated after blocking the immune-inhibitory programmed death 1 receptor
( American Society for Microbiology , 2018 , Article)Mycoplasma bovis-induced immune suppression is a major obstacle faced by the host for controlling infections. M. bovis impairment of antigen-specific T-cell responses is achieved through inhibiting the proliferation of ... -
Myxedema psychosis: A protocol for a systematic review and a pooled analysis
( Wolters Kluwer Health , 2020 , Article)Background: Myxedema psychosis (MP) is a rare presentation of hypothyroidism. Although known for >70 years, a significant lack of systematic literature describing this condition exists. This limits the clinician's ability ... -
Myxedema psychosis: Systematic review and pooled analysis
( Dove Medical Press , 2021 , Article)Background and Objective: The term myxedema psychosis (MP) was introduced to describe the occurrence of psychotic symptoms in patients with untreated hypothyroidism, but the optimal assessment and treatment of this condition ... -
NADPH-derived ROS generation drives fibrosis and endothelial-to-mesenchymal transition in systemic sclerosis: Potential cross talk with circulating miRNAs
( Walter de Gruyter , 2022 , Article)Systemic sclerosis (SSc) is an immune disorder characterized by diffuse fibrosis and vascular abnormalities of the affected organs. Although the etiopathology of this disease is largely unknown, endothelial damage and ... -
Nano-targeting vascular remodeling in cancer: Recent developments and future directions
( Elsevier , 2022 , Article Review)Tumor growth and progression are strictly dependent on the adequate blood supply of oxygen and nutrients. The formation of new blood vessels and vascular networks is essential to ensure this demand. Blood vessels also ... -
Nanomedicine for Cancer.
( Bentham Science Publishers , 2022 , Other)Over the past decades, oncology has occupied the lion’s share of all nanomedical applications [1-3]. In 2020, up to 65% of the clinical trials involving nanomaterials were attending to cancer therapeutics and diagnostics ... -
Nanoparticles: Attractive tools to treat colorectal cancer
( Elsevier , 2022 , Article)Colorectal Cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Despite the notable advances achieved over the last few decades, CRC remains a hard-to-treat deadly disease in many patients. This ... -
Nanotoxicology of dendrimers in the mammalian heart: Ex vivo and in vivo administration of g6 pamam nanoparticles impairs recovery of cardiac function following ischemia-reperfusion injury
( Dove Medical Press Ltd. , 2020 , Article)Aim: The effects of polyamidoamine (PAMAM) dendrimers on the mammalian heart are not completely understood. In this study, we have investigated the effects of a sixth-generation cationic dendrimer (G6 PAMAM) on cardiac ... -
Naturally-Occurring Bioactives in Oral Cancer: Preclinical and Clinical Studies, Bottlenecks and Future Directions
( IMR Press Limited , 2022 , Article)Oral cancer (OC) is the eighth most common cancer, particularly prevalent in developing countries. Current treatment includes a multidisciplinary approach, involving chemo, radio, and immunotherapy and surgery, which depends ... -
NDDNet: a deep learning model for predicting neurodegenerative diseases from gait pattern
( Springer Nature , 2023 , Article)Neurodegenerative diseases damage neuromuscular tissues and deteriorate motor neurons which affects the motor capacity of the patient. Particularly the walking gait is greatly influenced by the deterioration process. Early ... -
Neisseria gonorrhoeae Ketol-Acid Reductoisomerase Is a Potential Therapeutic Target
( IntechOpen , 2022 , Book chapter)The host-adapted human pathogen Neisseria gonorrhoeae is the causative agent of sexually transmitted infection gonorrhea. The increased emergence of gonorrhea infections worldwide, associated with the surging resistance ... -
The Net Clinical Benefit of Rivaroxaban Compared to Low-Molecular-Weight Heparin in the Treatment of Cancer-Associated Thrombosis: Systematic Review and Meta-Analysis
( SAGE , 2021 , Article)Cancer-associated thrombosis (CAT) carries significant morbidity and mortality. Low-molecular-weight heparin (LMWH) remains the standard of care, with recent systematic studies suggesting the efficacy and safety of rivaroxaban ...