Browsing College of Medicine by Title
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Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope
( Taylor and Francis Ltd. , 2023 , Article Review)Boronic acids/esters have recently emerged in the field of medicinal and pharmaceutical research due to their exceptional oxophilicity, low toxicity, and unique structure. They are known as potent enzyme inhibitors, cancer ... -
Origanum syriacum L. Attenuates the Malignant Phenotype of MDA-MB231 Breast Cancer Cells
( Frontiers Media , 2022 , Article)Breast cancer is the leading cause of cancer-related deaths among women. Among breast cancer types, triple negative breast cancer (TNBC) is the most aggressive, and is resistant to hormonal and chemotherapeutic treatments. ... -
Out-of-pocket expenditure on childhood infections and its financial burden on Indian households: Evidence from nationally representative household survey (2017–18)
( Public Library of Science , 2022 , Article)The key objective of this research was to estimate out of pocket expenditure (OOPE) incurred by the Indian households for the treatment of childhood infections. We estimated OOPE estimates on outpatient care and hospitalization ... -
Outcomes of guideline-based medical therapy in patients with acute heart failure and reduced left ventricular ejection fraction: Observations from the Gulf acute heart failure registry (Gulf CARE)
( Medicine (Baltimore) , 2022 , Article)AbstractThis study aimed to report on the use, predictors and outcomes of guideline-based medical therapy (GBMT) in patients with acute heart failure (HF) with reduced ejection fraction of <40% (HFrEF), from seven countries ... -
Outcomes of hyperglycaemia in pregnancy in Africa: Systematic review study protocol
( BMJ Publishing Group , 2021 , Article)Introduction The prevalence of diabetes mellitus globally has increased considerably over the past decades with a resultant increase in the incidence of diabetes-complicated pregnancies. Hyperglycaemia in pregnancy is the ... -
Ovarian Dysgerminoma in Pregnant Women with Viable Fetus: A Rare Case Report
( karger , 2021 , Article)Dysgerminoma is an uncommon malignant tumor arising from the germ cells of the ovary. Its association with pregnancy is extremely rare, with a reported incidence of about 0.2-1 per 100,000 pregnancies. Women in the ... -
Overconfident results with the bivariate random effects model for meta-analysis of diagnostic accuracy studies
( Wiley , 2022 , Other)Meta-analyses of diagnostic accuracy studies are a fundamental component of evidence-based medicine, and they are extensively used in medical imaging and the clinical laboratory. Techniques specifically developed to combine ... -
An overview of diabetes mellitus in pregnant women with obesity
( Elsevier , 2024 , Article)Rates of obesity are increasing world-wide with an estimated 1billion people projected to be obese by 2030 if current trends remain unchanged. Obesity currently considered one of the most significant associated factors of ... -
Oxidation–reduction potential and sperm DNA fragmentation, and their associations with sperm morphological anomalies amongst fertile and infertile men
( Arab Association of Urology , 2018 , Article)Objective: To assess seminal oxidation–reduction potential (ORP) and sperm DNA fragmentation (SDF) in male infertility and their relationships with sperm morphology in fertile and infertile men. Patients and methods: ... -
Oxidative Stress-Induced Endothelial Dysfunction in Cardiovascular Diseases
( IMR Press , 2022 , Article Review)Cardiovascular disease (CVD) is a major cause of mortality worldwide. A better understanding of the mechanisms underlying CVD is key for better management or prevention. Oxidative stress has been strongly implicated in the ... -
P-value driven methods were underpowered to detect publication bias: analysis of Cochrane review meta-analyses
( Elsevier , 2019 , Article)To investigate the effect of number of studies in a meta-analysis on the detection of publication bias using p-value driven methods. The proportion of meta-analyses detected by Egger's, Harbord's, Peters', and Begg's tests ... -
Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function
( Nature Research , 2023 , Article)Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the ... -
Papaver Plants: Current Insights on Phytochemical and Nutritional Composition Along with Biotechnological Applications
( Hindawi , 2022 , Article)The genus Papaver is highly esteemed in the pharmacy industry, in the culinary field, and as ornamental plants. These plants are also valued in traditional medicine. Among all Papaver species, Papaver somniferum L. (opium ... -
Paradoxical effects of statins on endothelial and cancer cells: the impact of concentrations
( Springer Nature , 2023 , Article)In addition to their lipid-lowering functions, statins elicit additional pleiotropic effects on apoptosis, angiogenesis, inflammation, senescence, and oxidative stress. Many of these effects have been reported in cancerous ... -
Parent and adolescent reports in assessing adolescent sleep problems: results from a large population study
( Wiley , 2016 , Article)To compare parent and adolescent reports in exploring adolescent sleep problems and to identify the factors associated with adolescent sleep problem disclosures. Parent (n = 5185) and adolescent reports (n = 5171, age=13.9 ... -
Patch Testing as a Diagnostic Method for DRESS Syndrome That Brings Us Closer to a Certain Result: Letter to the Editor
( Esmon Publicidad S.A. , 2022 , Other)The recent clinical report by García-Paz et al [1] on a case of DRESS syndrome due to amoxicillin makes for interesting reading. In this report, a 26-year-old man presented with a rash whose clinical phenotype (according ... -
Pathogenic Homocystinuria-Associated T236N Mutation Dramatically Alters the Biochemical Properties of Cystathionine Beta-Synthase Protein
( MDPI , 2024 , Article)Background: Cystathione beta-synthase (CBS) T236N is a novel mutation associated with pyridoxine non-responsiveness, which presents a significant difficulty in the medical treatment of homocystinuria. Reported severe ... -
Pathogenicity and virulence of monkeypox at the human-animal-ecology interface
( Taylor & Francis , 2023 , Article)Monkeypox (Mpox) was mostly limited to Central and Western Africa, but recently it has been reported globally. The current review presents an update on the virus, including ecology and evolution, possible drivers of ... -
Pathogenicity and virulence of monkeypox at the human-animal-ecology interface.
( Taylor & Francis Group. , 2023 , Article)Monkeypox (Mpox) was mostly limited to Central and Western Africa, but recently it has been reported globally. The current review presents an update on the virus, including ecology and evolution, possible drivers of ... -
Pathophysiological Aspects of the Development of Abdominal Aortic Aneurysm with a Special Focus on Mitochondrial Dysfunction and Genetic Associations
( De Gruyter Open Ltd , 2021 , Article Review)Abdominal aortic aneurysm (AAA) is a complex degenerative vascular disease, with considerable morbidity and mortality rates among the elderly population. The mortality of AAA is related to aneurysm expansion (the enlargement ...