College of Medicine: Recent submissions
Now showing items 981-1000 of 1518
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Staphylococcus aureus histone deacteylase-like enzyme is a potential target for adjuvant antibiotic discovery
( Hamad bin Khalifa University Press (HBKU Press) , 2022 , Article)Background: The rise in antibiotic resistance requires prompt action to reduce the burden of untreatable bacterial diseases1. Staphylococcus aureus is a human commensal and opportunistic pathogen that causes a broad range ... -
Oxidative Stress-Induced Endothelial Dysfunction in Cardiovascular Diseases
( IMR Press , 2022 , Article Review)Cardiovascular disease (CVD) is a major cause of mortality worldwide. A better understanding of the mechanisms underlying CVD is key for better management or prevention. Oxidative stress has been strongly implicated in the ... -
Health educators' professional agency in negotiating their Problem-Based Learning (PBL) facilitator roles: Q study.
( John Wiley & Sons, Ltd , 2022 , Article)University educators are expected to cope with emerging situations and complex issues in teaching and learning, and this requires them to be agentic and proactive. While professional agency of health educators has not been ... -
"Practice Educators' Academy": A fundamental step to experiential training success in Qatar
( Hamad bin Khalifa University Press (HBKU Press) , 2020 , Article)Background: Experiential learning is the backbone of many healthcare professional education programs 1 , and the quality of experiential learning is dependent on the skills, experiences, and proficiency of the clinical ... -
Molecular Evidence of Anticancer Activity of Camel Milk Combined with Camel Urine
( Austin Publishing Group , 2021 , Article)Camel Milk (CM) and Camel Urine (CU) is a traditional practice in the Middle East and other countries as an alternative treatment against cancer. We hypothesized that a combination of CM and CU (CM+CU), used at ... -
SOD2, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression
( MDPI , 2022 , Article Review)CD44, a cell-adhesion molecule has a dual role in tumor growth and progression; it acts as a tumor suppressor as well as a tumor promoter. In our previous work, we developed a tetracycline-off regulated expression of CD44’s ... -
Low risk of serological cross-reactivity between the dengue virus and SARS-CoV-2 IgG antibodies using advanced detection assays.
( Karger , 2022 , Report)Several studies have reported serological cross-reactivity of the immune responses between SARS-CoV-2 and DENV. Most of the available studies are based on the point of care (POC) rapid testing kits. However, some rapid ... -
Performance evaluation of novel fluorescent-based lateral flow immunoassay (LFIA) for rapid detection and quantification of total anti-SARS-CoV-2 S-RBD binding antibodies in infected individuals
( Elsevier , 2022 , Article)The vast majority of the commercially available LFIA is used to detect SARS-CoV-2 antibodies qualitatively. Recently, a novel fluorescence-based LIFA test was developed for quantitative measurement of the total binding ... -
The Effect of Telemedicine on Patients' Compliance in Family Medicine Follow-ups in Qatar
( Hamad bin Khalifa University Press (HBKU Press) , 2022 , Article)Introduction: Telemedicine is the delivery of health care services to patients distantly. During the Coronavirus Disease 2019 (COVID-19) pandemic, telemedicine has become an essential implement in delivering healthcare ... -
The role of antibiotic resistance mobile genetic element MCR-1 in enhancing bacterial survival in macrophages
( Hamad bin Khalifa University Press (HBKU Press) , 2022 , Article)Background: Antimicrobial resistance (AMR) determinants such as mobile colistin resistance (MCR-1) that encodes colistin resistance are increasingly spreading in healthcare-associated and community-acquired infections. 1 ... -
QCovSML: A reliable COVID-19 detection system using CBC biomarkers by a stacking machine learning model
( Elsevier , 2022 , Article)The reverse transcription-polymerase chain reaction (RT-PCR) test is considered the current gold standard for the detection of coronavirus disease (COVID-19), although it suffers from some shortcomings, namely comparatively ... -
Follicular dendritic cells
( Wiley , 2021 , Article Review)Follicular dendritic cells (FDCs) are unique accessory immune cells that contribute to the regulation of humoral immunity. They are multitasker cells essential for the organization and maintenance of the lymphoid architecture, ... -
The prevalence of adaptive immunity to COVID-19 and reinfection after recovery - a comprehensive systematic review and meta-analysis.
( Taylor & Francis , 2022 , Article)This study aims to estimate the prevalence and longevity of detectable SARS-CoV-2 antibodies and T and B memory cells after recovery. In addition, the prevalence of COVID-19 reinfection and the preventive efficacy of ... -
Autosomal Recessive Primary Microcephaly: Not Just a Small Brain
( Frontiers Media , 2022 , Article Review)Microcephaly or reduced head circumference results from a multitude of abnormal developmental processes affecting brain growth and/or leading to brain atrophy. Autosomal recessive primary microcephaly (MCPH) is the prototype ... -
Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation
( American Chemical Society , 2021 , Article)Prolonged exposure to opioid receptor agonists triggers adaptations in the adenylyl cyclase (AC) pathway that lead to enhanced production of cyclic adenosine monophosphate (cAMP) upon withdrawal. This cellular phenomenon ... -
The Clinical Pharmacist-Led Consultation for Infectious Diseases in Guizhou Province, China: A Survey Among Hospital Pharmacies
(2020 , Article)Background: As antimicrobial resistance became an increasing threat to global public health, Clinical Pharmacist-led Consultation (CPC) for Infectious Diseases (ID) was developed in China. We conducted a survey among ... -
Urine as a Main Effector in Urological Tissue Engineering—A Double-Edged Sword
(2020 , Article)In order to reconstruct injured urinary tract tissues, biodegradable scaffolds with autologous seeded cells are explored in this work. However, when cells are obtained via biopsy from individuals who have damaged organs ... -
Prevalence of asymptomatic hyperuricemia and its association with prediabetes, dyslipidemia and subclinical inflammation markers among young healthy adults in Qatar
( BMC , 2022 , Article)Aim: The aim of this study is to investigate the prevalence of asymptomatic hyperuricemia in Qatar and to examine its association with changes in markers of dyslipidemia, prediabetes and subclinical inflammation. Methods: ... -
Circulating microvesicles and exosomes in small cell lung cancer by quantitative proteomics
( BMC , 2022 , Article)Background: Early detection of small cell lung cancer (SCLC) crucially demands highly reliable markers. Growing evidence suggests that extracellular vesicles carry tumor cell-specific cargo suitable as protein markers in ... -
Involvement of caveolae in hyperglycemia-induced changes in adiponectin and leptin expressions in vascular smooth muscle cells
( Elsevier , 2021 , Article)Hyperglycemia exerts various harmful effects on the vasculature. Studies have shown an association between the levels of the adipokines leptin and adiponectin (APN) and vascular complications in diabetes mellitus. The aim ...
